Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967687719> ?p ?o ?g. }
- W2967687719 endingPage "119422" @default.
- W2967687719 startingPage "119422" @default.
- W2967687719 abstract "Highly specific and effective cancer phototherapy remains as a great challenge. Herein, a smart nanoplatform (TENAB NP) sequentially responsive to light, low pH and hypoxia is demonstrated for multi-mode imaging guided synergistic cancer therapy with negligible skin phototoxicity. Upon 808-nm laser irradiation, TENAB NPs can generate hyperthermia to melt the phase change material (PCM-LASA) coat and thereafter release chemo-drug tirapazamine (TPZ). Meanwhile, under acidic pH, photosensitizer ENAB would turn off its charge-transfer state, generating prominent 1O2 for photodynamic therapy (PDT) and heat for photothermal therapy (PTT), respectively. Accompanied with PDT-induced hypoxia, the released TPZ can be activated into its cytotoxic form for tumor cells killing. Notably, owing to phase change material LASA coat and ENAB's pH sensitivity, TENAB NPs show negligible photosensitization to skin and normal tissues. As the multi-stimuli responsive mechanism, TENAB NPs demonstrate a promising future in cancer photo-chemo theranostics with excellent skin protection." @default.
- W2967687719 created "2019-08-22" @default.
- W2967687719 creator A5002156928 @default.
- W2967687719 creator A5016131399 @default.
- W2967687719 creator A5022012224 @default.
- W2967687719 creator A5046978138 @default.
- W2967687719 creator A5056849798 @default.
- W2967687719 creator A5071157860 @default.
- W2967687719 creator A5072214656 @default.
- W2967687719 creator A5084000653 @default.
- W2967687719 creator A5087199136 @default.
- W2967687719 creator A5087364678 @default.
- W2967687719 date "2019-11-01" @default.
- W2967687719 modified "2023-10-11" @default.
- W2967687719 title "Photothermal-pH-hypoxia responsive multifunctional nanoplatform for cancer photo-chemo therapy with negligible skin phototoxicity" @default.
- W2967687719 cites W1894882326 @default.
- W2967687719 cites W1938186462 @default.
- W2967687719 cites W2003849046 @default.
- W2967687719 cites W2014506753 @default.
- W2967687719 cites W2016935627 @default.
- W2967687719 cites W2050023299 @default.
- W2967687719 cites W2092647316 @default.
- W2967687719 cites W2136800292 @default.
- W2967687719 cites W2324649191 @default.
- W2967687719 cites W2403102474 @default.
- W2967687719 cites W2440755571 @default.
- W2967687719 cites W2464639368 @default.
- W2967687719 cites W2549272242 @default.
- W2967687719 cites W2563570451 @default.
- W2967687719 cites W2567120106 @default.
- W2967687719 cites W2580488838 @default.
- W2967687719 cites W2580621433 @default.
- W2967687719 cites W2583207915 @default.
- W2967687719 cites W2598243100 @default.
- W2967687719 cites W2605407725 @default.
- W2967687719 cites W2611800801 @default.
- W2967687719 cites W2615993918 @default.
- W2967687719 cites W2617682450 @default.
- W2967687719 cites W2619224638 @default.
- W2967687719 cites W2626099380 @default.
- W2967687719 cites W2636608044 @default.
- W2967687719 cites W2700309767 @default.
- W2967687719 cites W2727421336 @default.
- W2967687719 cites W2729463162 @default.
- W2967687719 cites W2737866071 @default.
- W2967687719 cites W2744476812 @default.
- W2967687719 cites W2746817330 @default.
- W2967687719 cites W2753511090 @default.
- W2967687719 cites W2756558969 @default.
- W2967687719 cites W2764028271 @default.
- W2967687719 cites W2767711517 @default.
- W2967687719 cites W2782879922 @default.
- W2967687719 cites W2783110230 @default.
- W2967687719 cites W2784549607 @default.
- W2967687719 cites W2791785017 @default.
- W2967687719 cites W2796408994 @default.
- W2967687719 cites W2809011555 @default.
- W2967687719 cites W2896035171 @default.
- W2967687719 cites W2896897608 @default.
- W2967687719 cites W2900356114 @default.
- W2967687719 cites W2907200033 @default.
- W2967687719 cites W2911264664 @default.
- W2967687719 cites W2914293180 @default.
- W2967687719 cites W2921584104 @default.
- W2967687719 doi "https://doi.org/10.1016/j.biomaterials.2019.119422" @default.
- W2967687719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31437723" @default.
- W2967687719 hasPublicationYear "2019" @default.
- W2967687719 type Work @default.
- W2967687719 sameAs 2967687719 @default.
- W2967687719 citedByCount "98" @default.
- W2967687719 countsByYear W29676877192019 @default.
- W2967687719 countsByYear W29676877192020 @default.
- W2967687719 countsByYear W29676877192021 @default.
- W2967687719 countsByYear W29676877192022 @default.
- W2967687719 countsByYear W29676877192023 @default.
- W2967687719 crossrefType "journal-article" @default.
- W2967687719 hasAuthorship W2967687719A5002156928 @default.
- W2967687719 hasAuthorship W2967687719A5016131399 @default.
- W2967687719 hasAuthorship W2967687719A5022012224 @default.
- W2967687719 hasAuthorship W2967687719A5046978138 @default.
- W2967687719 hasAuthorship W2967687719A5056849798 @default.
- W2967687719 hasAuthorship W2967687719A5071157860 @default.
- W2967687719 hasAuthorship W2967687719A5072214656 @default.
- W2967687719 hasAuthorship W2967687719A5084000653 @default.
- W2967687719 hasAuthorship W2967687719A5087199136 @default.
- W2967687719 hasAuthorship W2967687719A5087364678 @default.
- W2967687719 hasConcept C109316439 @default.
- W2967687719 hasConcept C121608353 @default.
- W2967687719 hasConcept C126322002 @default.
- W2967687719 hasConcept C136229726 @default.
- W2967687719 hasConcept C155672457 @default.
- W2967687719 hasConcept C171250308 @default.
- W2967687719 hasConcept C178790620 @default.
- W2967687719 hasConcept C182606246 @default.
- W2967687719 hasConcept C185592680 @default.
- W2967687719 hasConcept C192562407 @default.
- W2967687719 hasConcept C202751555 @default.
- W2967687719 hasConcept C204399865 @default.