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- W2967751307 endingPage "100945" @default.
- W2967751307 startingPage "100945" @default.
- W2967751307 abstract "Ghrelin, which has many important physiological roles, such as stimulating food intake, regulating energy homeostasis, and releasing insulin, has recently been studied for its roles in a diverse range of neurological disorders. Despite the several functions of ghrelin in the central nervous system, whether it works as a therapeutic agent for neurological dysfunction has been unclear. Altered levels and various roles of ghrelin have been reported in Alzheimer's disease (AD), which is characterized by the accumulation of misfolded proteins resulting in synaptic loss and cognitive decline. Interestingly, treatment with ghrelin or with the agonist of ghrelin receptor showed attenuation in several cases of AD-related pathology. These findings suggest the potential therapeutic implications of ghrelin in the pathogenesis of AD. In the present review, we summarized the roles of ghrelin in AD pathogenesis, amyloid beta (Aβ) homeostasis, tau hyperphosphorylation, neuroinflammation, mitochondrial deficit, synaptic dysfunction and cognitive impairment. The findings from this review suggest that ghrelin has a novel therapeutic potential for AD treatment. Thus, rigorously designed studies are needed to establish an effective AD-modifying strategy." @default.
- W2967751307 created "2019-08-22" @default.
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- W2967751307 creator A5088200201 @default.
- W2967751307 creator A5090988274 @default.
- W2967751307 date "2019-11-01" @default.
- W2967751307 modified "2023-09-24" @default.
- W2967751307 title "Ghrelin in Alzheimer’s disease: Pathologic roles and therapeutic implications" @default.
- W2967751307 cites W138470071 @default.
- W2967751307 cites W1495997476 @default.
- W2967751307 cites W1511410209 @default.
- W2967751307 cites W1520100911 @default.
- W2967751307 cites W1521652786 @default.
- W2967751307 cites W1525765510 @default.
- W2967751307 cites W1541218967 @default.
- W2967751307 cites W1550247880 @default.
- W2967751307 cites W1552673037 @default.
- W2967751307 cites W1575367484 @default.
- W2967751307 cites W1607364459 @default.
- W2967751307 cites W1616471316 @default.
- W2967751307 cites W170237590 @default.
- W2967751307 cites W1830554079 @default.
- W2967751307 cites W1842603578 @default.
- W2967751307 cites W1969583687 @default.
- W2967751307 cites W1969812373 @default.
- W2967751307 cites W1971200109 @default.
- W2967751307 cites W1971743791 @default.
- W2967751307 cites W1972625995 @default.
- W2967751307 cites W1974894459 @default.
- W2967751307 cites W1976521535 @default.
- W2967751307 cites W1980750700 @default.
- W2967751307 cites W1980825524 @default.
- W2967751307 cites W1983232559 @default.
- W2967751307 cites W1983436639 @default.
- W2967751307 cites W1983522119 @default.
- W2967751307 cites W1984652813 @default.
- W2967751307 cites W1984924722 @default.
- W2967751307 cites W1985071684 @default.
- W2967751307 cites W1985621776 @default.
- W2967751307 cites W1986730065 @default.
- W2967751307 cites W1989703960 @default.
- W2967751307 cites W1990095603 @default.
- W2967751307 cites W1990752558 @default.
- W2967751307 cites W1990962744 @default.
- W2967751307 cites W1991370612 @default.
- W2967751307 cites W1991742828 @default.
- W2967751307 cites W1992487195 @default.
- W2967751307 cites W1992955585 @default.
- W2967751307 cites W1993016490 @default.
- W2967751307 cites W1994125564 @default.
- W2967751307 cites W1996200834 @default.
- W2967751307 cites W1998126371 @default.
- W2967751307 cites W1998440070 @default.
- W2967751307 cites W2001752726 @default.
- W2967751307 cites W2002181764 @default.
- W2967751307 cites W2002209256 @default.
- W2967751307 cites W2004349171 @default.
- W2967751307 cites W2005483591 @default.
- W2967751307 cites W2008050572 @default.
- W2967751307 cites W2008767130 @default.
- W2967751307 cites W2009458913 @default.
- W2967751307 cites W2009787733 @default.
- W2967751307 cites W2010394948 @default.
- W2967751307 cites W2013469932 @default.
- W2967751307 cites W2015037392 @default.
- W2967751307 cites W2018866195 @default.
- W2967751307 cites W2019196493 @default.
- W2967751307 cites W2020486984 @default.
- W2967751307 cites W2021247637 @default.
- W2967751307 cites W2022581394 @default.
- W2967751307 cites W2025308399 @default.
- W2967751307 cites W2027867206 @default.
- W2967751307 cites W2027989695 @default.
- W2967751307 cites W2028471410 @default.
- W2967751307 cites W2028671815 @default.
- W2967751307 cites W2030320815 @default.
- W2967751307 cites W2030769095 @default.
- W2967751307 cites W2035600501 @default.
- W2967751307 cites W2036288989 @default.
- W2967751307 cites W2036860335 @default.
- W2967751307 cites W2042614482 @default.
- W2967751307 cites W2045613228 @default.
- W2967751307 cites W2046499742 @default.
- W2967751307 cites W2047589919 @default.
- W2967751307 cites W2049771698 @default.
- W2967751307 cites W2052105761 @default.
- W2967751307 cites W2052236118 @default.
- W2967751307 cites W2053116734 @default.
- W2967751307 cites W2053215139 @default.