FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967752496> ?p ?o ?g. }

• W2967752496 endingPage "765" @default.
• W2967752496 startingPage "760" @default.
• W2967752496 abstract "To investigate the inhibitory effect of matrine on the proliferation of human non-small cell lung cancer (NSCLC) and explore the possible molecular mechanism.Cultured human NSCLC A549 cells were treated with 0.4, 0.8, 1.2, 1.6, and 2.0 g/L matrine for 24, 48 or 72 h. CCK-8 assay was used for measuring the changes in A549 cell viability. The morphological changes of the cells were observed under a fluorescence microscope, and flow cytometry was employed for analyzing the cell apoptosis. The effects of matrine and the PI3K specific inhibitor LY294002 (10 nmol/L) on AKT pathway and autophagy-related proteins in A549 cells were investigated using Western blotting.Matrine significantly inhibited the proliferation of A549 cells in a time- and dose-dependent manner (P < 0.05). At the concentration of 1.6 g/L or higher, matrine caused obvious cell shrinkage and fragmentation and significantly increased floating cells; autophagy vacuoles could be observed in the cells after acridine orange staining. Within the concentrations range of 0.8-1.6 g/L, matrine time- and dosedependently increased the cell apoptosis. Treatment of the cells with 1.6 g/L matrine and 10 nmol/L LY294002 resulted in significantly lowered expressions of p-AKT and p-mTOR proteins and increased the expression of light chain 3B (LC 3B), an autophagy-related protein, as compared with those in the control cells (P < 0.05).We demonstrate that matrine inhibits the proliferation and induces autophagy and apoptosis of A549 cells by deactivating AKT pathway, suggesting the potential of matrine as an anti-cancer agent for lung cancer." @default.
• W2967752496 created "2019-08-22" @default.
• W2967752496 creator A5003458854 @default.
• W2967752496 creator A5034507636 @default.
• W2967752496 creator A5040935882 @default.
• W2967752496 creator A5058060903 @default.
• W2967752496 creator A5066018433 @default.
• W2967752496 creator A5070623919 @default.
• W2967752496 creator A5082816966 @default.
• W2967752496 creator A5089703861 @default.
• W2967752496 date "2019-07-30" @default.
• W2967752496 modified "2023-09-25" @default.
• W2967752496 title "[Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway]." @default.
• W2967752496 cites W2008391194 @default.
• W2967752496 cites W2009078060 @default.
• W2967752496 cites W2022318020 @default.
• W2967752496 cites W2035826674 @default.
• W2967752496 cites W2037139573 @default.
• W2967752496 cites W2054841768 @default.
• W2967752496 cites W2065477010 @default.
• W2967752496 cites W2071466153 @default.
• W2967752496 cites W2071795319 @default.
• W2967752496 cites W2077195956 @default.
• W2967752496 cites W2085959358 @default.
• W2967752496 cites W2088157123 @default.
• W2967752496 cites W2096100878 @default.
• W2967752496 cites W2099725888 @default.
• W2967752496 cites W2109755284 @default.
• W2967752496 cites W2148579454 @default.
• W2967752496 cites W2160982674 @default.
• W2967752496 cites W2166084034 @default.
• W2967752496 cites W2398311071 @default.
• W2967752496 cites W2404531172 @default.
• W2967752496 cites W2464657541 @default.
• W2967752496 cites W2521262762 @default.
• W2967752496 cites W2595645511 @default.
• W2967752496 cites W2596244764 @default.
• W2967752496 cites W2740314095 @default.
• W2967752496 cites W2791240642 @default.
• W2967752496 cites W2807550424 @default.
• W2967752496 cites W2810738289 @default.
• W2967752496 cites W2917837889 @default.
• W2967752496 doi "https://doi.org/10.12122/j.issn.1673-4254.2019.07.02" @default.
• W2967752496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765564" @default.
• W2967752496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31340906" @default.
• W2967752496 hasPublicationYear "2019" @default.
• W2967752496 type Work @default.
• W2967752496 sameAs 2967752496 @default.
• W2967752496 citedByCount "5" @default.
• W2967752496 countsByYear W29677524962022 @default.
• W2967752496 crossrefType "journal-article" @default.
• W2967752496 hasAuthorship W2967752496A5003458854 @default.
• W2967752496 hasAuthorship W2967752496A5034507636 @default.
• W2967752496 hasAuthorship W2967752496A5040935882 @default.
• W2967752496 hasAuthorship W2967752496A5058060903 @default.
• W2967752496 hasAuthorship W2967752496A5066018433 @default.
• W2967752496 hasAuthorship W2967752496A5070623919 @default.
• W2967752496 hasAuthorship W2967752496A5082816966 @default.
• W2967752496 hasAuthorship W2967752496A5089703861 @default.
• W2967752496 hasConcept C153911025 @default.
• W2967752496 hasConcept C185592680 @default.
• W2967752496 hasConcept C190283241 @default.
• W2967752496 hasConcept C203522944 @default.
• W2967752496 hasConcept C2776545273 @default.
• W2967752496 hasConcept C2779102032 @default.
• W2967752496 hasConcept C43617362 @default.
• W2967752496 hasConcept C53227056 @default.
• W2967752496 hasConcept C55493867 @default.
• W2967752496 hasConcept C62112901 @default.
• W2967752496 hasConcept C75217442 @default.
• W2967752496 hasConcept C81729549 @default.
• W2967752496 hasConcept C86554907 @default.
• W2967752496 hasConcept C86803240 @default.
• W2967752496 hasConcept C95444343 @default.
• W2967752496 hasConceptScore W2967752496C153911025 @default.
• W2967752496 hasConceptScore W2967752496C185592680 @default.
• W2967752496 hasConceptScore W2967752496C190283241 @default.
• W2967752496 hasConceptScore W2967752496C203522944 @default.
• W2967752496 hasConceptScore W2967752496C2776545273 @default.
• W2967752496 hasConceptScore W2967752496C2779102032 @default.
• W2967752496 hasConceptScore W2967752496C43617362 @default.
• W2967752496 hasConceptScore W2967752496C53227056 @default.
• W2967752496 hasConceptScore W2967752496C55493867 @default.
• W2967752496 hasConceptScore W2967752496C62112901 @default.
• W2967752496 hasConceptScore W2967752496C75217442 @default.
• W2967752496 hasConceptScore W2967752496C81729549 @default.
• W2967752496 hasConceptScore W2967752496C86554907 @default.
• W2967752496 hasConceptScore W2967752496C86803240 @default.
• W2967752496 hasConceptScore W2967752496C95444343 @default.
• W2967752496 hasIssue "7" @default.
• W2967752496 hasLocation W29677524961 @default.
• W2967752496 hasOpenAccess W2967752496 @default.
• W2967752496 hasPrimaryLocation W29677524961 @default.
• W2967752496 hasRelatedWork W2070759795 @default.
• W2967752496 hasRelatedWork W2566260826 @default.
• W2967752496 hasRelatedWork W2789867867 @default.
• W2967752496 hasRelatedWork W2892441165 @default.
• W2967752496 hasRelatedWork W2941112610 @default.

• next