Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967769237> ?p ?o ?g. }
- W2967769237 abstract "By extending the crude Goldman-Hodgkin-Katz electrodiffusion model for resting-state membrane potentials in perfused giant axons of squid, we reformulate the Hodgkin-Huxley (HH) phenomenological quantitative model to create a new model which is simpler and based more fundamentally on electrodiffusion principles. Our dynamical system, like that of HH, behaves as a 4-dimensional resonator exhibiting subthreshold oscillations. The predicted speed of propagating action potentials at 20 degrees Celsius is in good agreement with the HH experimental value at 18.5 degrees Celsius. After the external concentration of calcium ions is reduced, the generation of repetitive rebound action potentials is predicted by our model, in agreement with experiment, when the membrane is stimulated by a brief (0.1 ms) depolarizing current. Unlike the HH model, our model predicts, in agreement with experiment, that prolonged constant-current stimulation does not generate spike trains in perfused axons. Our resonator model predicts rebound spiking following prolonged hyperpolarizing stimulation, observed at 18.5 degrees Celsius by HH but not predicted at this temperature by their quantitative model. Spiking promoted by brief hyperpolarization is also predicted, at room temperature, by our electrodiffusion model, but only at much lower temperatures (ca. 6 degrees Celsius) by the HH model. We discuss qualitatively, more completely than do HH, temperature dependences of the various physical effects which determine resting and action potentials." @default.
- W2967769237 created "2019-08-22" @default.
- W2967769237 creator A5015229015 @default.
- W2967769237 creator A5051703757 @default.
- W2967769237 date "2019-08-14" @default.
- W2967769237 modified "2023-09-27" @default.
- W2967769237 title "Improved Hodgkin & Huxley-type model for action potentials in squid" @default.
- W2967769237 cites W1507311464 @default.
- W2967769237 cites W1677882857 @default.
- W2967769237 cites W176118634 @default.
- W2967769237 cites W19317540 @default.
- W2967769237 cites W1962562033 @default.
- W2967769237 cites W1966123655 @default.
- W2967769237 cites W1968190185 @default.
- W2967769237 cites W1968435495 @default.
- W2967769237 cites W1981299503 @default.
- W2967769237 cites W1985940938 @default.
- W2967769237 cites W1987812159 @default.
- W2967769237 cites W1987985500 @default.
- W2967769237 cites W1989659026 @default.
- W2967769237 cites W2000602225 @default.
- W2967769237 cites W2006581331 @default.
- W2967769237 cites W2008002200 @default.
- W2967769237 cites W2009438895 @default.
- W2967769237 cites W2010690165 @default.
- W2967769237 cites W2010840797 @default.
- W2967769237 cites W2011472228 @default.
- W2967769237 cites W2019484205 @default.
- W2967769237 cites W2019549306 @default.
- W2967769237 cites W2020704624 @default.
- W2967769237 cites W2028274352 @default.
- W2967769237 cites W2032725371 @default.
- W2967769237 cites W2032734987 @default.
- W2967769237 cites W2036260386 @default.
- W2967769237 cites W2038010140 @default.
- W2967769237 cites W2038792242 @default.
- W2967769237 cites W2055912261 @default.
- W2967769237 cites W2059496396 @default.
- W2967769237 cites W2062132446 @default.
- W2967769237 cites W2063502459 @default.
- W2967769237 cites W2063576299 @default.
- W2967769237 cites W2065860576 @default.
- W2967769237 cites W2066784785 @default.
- W2967769237 cites W2067081534 @default.
- W2967769237 cites W2086112294 @default.
- W2967769237 cites W2088418136 @default.
- W2967769237 cites W2090412307 @default.
- W2967769237 cites W2091564611 @default.
- W2967769237 cites W2092520818 @default.
- W2967769237 cites W2092875140 @default.
- W2967769237 cites W2096872205 @default.
- W2967769237 cites W2097400197 @default.
- W2967769237 cites W2104415321 @default.
- W2967769237 cites W2105600530 @default.
- W2967769237 cites W2119689152 @default.
- W2967769237 cites W2124201767 @default.
- W2967769237 cites W2126725618 @default.
- W2967769237 cites W2127962404 @default.
- W2967769237 cites W2133575718 @default.
- W2967769237 cites W2147142035 @default.
- W2967769237 cites W2153412362 @default.
- W2967769237 cites W2158738489 @default.
- W2967769237 cites W2169938087 @default.
- W2967769237 cites W2172225359 @default.
- W2967769237 cites W2588940923 @default.
- W2967769237 cites W2600521737 @default.
- W2967769237 cites W316919195 @default.
- W2967769237 cites W3196492948 @default.
- W2967769237 cites W629519280 @default.
- W2967769237 cites W2077884084 @default.
- W2967769237 hasPublicationYear "2019" @default.
- W2967769237 type Work @default.
- W2967769237 sameAs 2967769237 @default.
- W2967769237 citedByCount "0" @default.
- W2967769237 crossrefType "posted-content" @default.
- W2967769237 hasAuthorship W2967769237A5015229015 @default.
- W2967769237 hasAuthorship W2967769237A5051703757 @default.
- W2967769237 hasConcept C101877181 @default.
- W2967769237 hasConcept C119599485 @default.
- W2967769237 hasConcept C121332964 @default.
- W2967769237 hasConcept C12554922 @default.
- W2967769237 hasConcept C127413603 @default.
- W2967769237 hasConcept C131453863 @default.
- W2967769237 hasConcept C169760540 @default.
- W2967769237 hasConcept C181911157 @default.
- W2967769237 hasConcept C185592680 @default.
- W2967769237 hasConcept C18903297 @default.
- W2967769237 hasConcept C195221683 @default.
- W2967769237 hasConcept C2777743550 @default.
- W2967769237 hasConcept C4141045 @default.
- W2967769237 hasConcept C46141821 @default.
- W2967769237 hasConcept C55493867 @default.
- W2967769237 hasConcept C6425155 @default.
- W2967769237 hasConcept C66974803 @default.
- W2967769237 hasConcept C81370116 @default.
- W2967769237 hasConcept C86803240 @default.
- W2967769237 hasConcept C97355855 @default.
- W2967769237 hasConceptScore W2967769237C101877181 @default.
- W2967769237 hasConceptScore W2967769237C119599485 @default.
- W2967769237 hasConceptScore W2967769237C121332964 @default.