Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967794080> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2967794080 abstract "Abstract INTRODUCTION: Brain metastasis velocity (BMV) is a prognostic metric that describes the recurrence rate of new brain metastases after initial treatment with radiosurgery (SRS). We have previously risk stratified patients into high, intermediate, and low-risk BMV groups, which correlates with overall survival (OS). We sought to externally validate BMV in a multi-institutional setting. METHODS: Patients from nine academic centers were treated with upfront SRS; the validation cohort consisted of data from eight institutions not previously used to define BMV. Patients were classified by BMV into low (< 4 BMV), intermediate (4–13 BMV), and high-risk groups (>13 BMV). Time-to-event outcomes were estimated using the Kaplan-Meier method. Cox proportional hazards methods were used to estimate the effect of BMV and salvage modality on OS. RESULTS: Of 2829 patients, 2092 patients were included in the validation dataset. Of these, 921 (44.0%) experienced distant brain failure (DBF). Median OS from initial SRS was 11.2 mo. Median OS for BMV < 4, BMV 4–13, and BMV > 13 were 12.5 mo, 7.0 mo, and 4.6 mo (p < 0.0001). Compared to initial salvage with WBRT, salvage SRS was associated with improved OS following DBF for BMV < 4 (p = 0.05), BMV 4–13 (p = 0.002) and BMV > 13 (p = 0.0001). CONCLUSIONS: This multi-institutional dataset validates BMV as a predictor of OS following initial SRS. BMV is being utilized in upcoming multi-institutional randomized controlled trials as a stratification variable for salvage whole brain radiation vs salvage SRS after DBF." @default.
- W2967794080 created "2019-08-22" @default.
- W2967794080 creator A5003098218 @default.
- W2967794080 creator A5007499900 @default.
- W2967794080 creator A5022886652 @default.
- W2967794080 creator A5038229756 @default.
- W2967794080 creator A5041869023 @default.
- W2967794080 creator A5050923145 @default.
- W2967794080 creator A5053414244 @default.
- W2967794080 creator A5058373918 @default.
- W2967794080 creator A5058440874 @default.
- W2967794080 creator A5059739662 @default.
- W2967794080 creator A5060552036 @default.
- W2967794080 creator A5070556817 @default.
- W2967794080 creator A5072259049 @default.
- W2967794080 creator A5074737662 @default.
- W2967794080 creator A5088249121 @default.
- W2967794080 date "2019-08-01" @default.
- W2967794080 modified "2023-09-26" @default.
- W2967794080 title "RADI-31. MULTI-INSTITUTIONAL VALIDATION OF BRAIN METASTASIS VELOCITY, A RECENTLY DEFINED PREDICTOR OF OUTCOMES FOLLOWING STEREOTACTIC RADIOSURGERY" @default.
- W2967794080 doi "https://doi.org/10.1093/noajnl/vdz014.123" @default.
- W2967794080 hasPublicationYear "2019" @default.
- W2967794080 type Work @default.
- W2967794080 sameAs 2967794080 @default.
- W2967794080 citedByCount "0" @default.
- W2967794080 crossrefType "journal-article" @default.
- W2967794080 hasAuthorship W2967794080A5003098218 @default.
- W2967794080 hasAuthorship W2967794080A5007499900 @default.
- W2967794080 hasAuthorship W2967794080A5022886652 @default.
- W2967794080 hasAuthorship W2967794080A5038229756 @default.
- W2967794080 hasAuthorship W2967794080A5041869023 @default.
- W2967794080 hasAuthorship W2967794080A5050923145 @default.
- W2967794080 hasAuthorship W2967794080A5053414244 @default.
- W2967794080 hasAuthorship W2967794080A5058373918 @default.
- W2967794080 hasAuthorship W2967794080A5058440874 @default.
- W2967794080 hasAuthorship W2967794080A5059739662 @default.
- W2967794080 hasAuthorship W2967794080A5060552036 @default.
- W2967794080 hasAuthorship W2967794080A5070556817 @default.
- W2967794080 hasAuthorship W2967794080A5072259049 @default.
- W2967794080 hasAuthorship W2967794080A5074737662 @default.
- W2967794080 hasAuthorship W2967794080A5088249121 @default.
- W2967794080 hasBestOaLocation W29677940801 @default.
- W2967794080 hasConcept C121608353 @default.
- W2967794080 hasConcept C126322002 @default.
- W2967794080 hasConcept C143998085 @default.
- W2967794080 hasConcept C2778164965 @default.
- W2967794080 hasConcept C2779013556 @default.
- W2967794080 hasConcept C2780387249 @default.
- W2967794080 hasConcept C3019894029 @default.
- W2967794080 hasConcept C50382708 @default.
- W2967794080 hasConcept C509974204 @default.
- W2967794080 hasConcept C71924100 @default.
- W2967794080 hasConcept C72563966 @default.
- W2967794080 hasConceptScore W2967794080C121608353 @default.
- W2967794080 hasConceptScore W2967794080C126322002 @default.
- W2967794080 hasConceptScore W2967794080C143998085 @default.
- W2967794080 hasConceptScore W2967794080C2778164965 @default.
- W2967794080 hasConceptScore W2967794080C2779013556 @default.
- W2967794080 hasConceptScore W2967794080C2780387249 @default.
- W2967794080 hasConceptScore W2967794080C3019894029 @default.
- W2967794080 hasConceptScore W2967794080C50382708 @default.
- W2967794080 hasConceptScore W2967794080C509974204 @default.
- W2967794080 hasConceptScore W2967794080C71924100 @default.
- W2967794080 hasConceptScore W2967794080C72563966 @default.
- W2967794080 hasLocation W29677940801 @default.
- W2967794080 hasLocation W29677940802 @default.
- W2967794080 hasOpenAccess W2967794080 @default.
- W2967794080 hasPrimaryLocation W29677940801 @default.
- W2967794080 hasRelatedWork W10340480 @default.
- W2967794080 hasRelatedWork W11710446 @default.
- W2967794080 hasRelatedWork W14093475 @default.
- W2967794080 hasRelatedWork W14845348 @default.
- W2967794080 hasRelatedWork W16125376 @default.
- W2967794080 hasRelatedWork W18466314 @default.
- W2967794080 hasRelatedWork W20398541 @default.
- W2967794080 hasRelatedWork W466659 @default.
- W2967794080 hasRelatedWork W7873026 @default.
- W2967794080 hasRelatedWork W869992 @default.
- W2967794080 isParatext "false" @default.
- W2967794080 isRetracted "false" @default.
- W2967794080 magId "2967794080" @default.
- W2967794080 workType "article" @default.