FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967842372> ?p ?o ?g. }

• W2967842372 abstract "Pre-exposure prophylaxis (PrEP) is a promising and effective tool to prevent human immunodeficiency virus (HIV) transmission; however, context-specific data to guide optimal implementation are currently lacking in China. This study aims to systematically collect comprehensive, empirical data to determine effective ways to implement PrEP among at-risk men who have sex with men (MSM) in China.The CROPrEP project, a real-world study of PrEP use, will recruit 1000 high-risk HIV-negative MSM participants from four cities in China, who will be able to choose between daily or event-driven dosing regimens, according to their preference. Participants will be followed up at months 1, 3, 6, 9, and 12 for PrEP provision, clinical evaluation, laboratory testing (e.g., emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) concentrations, and HIV/sexually transmitted infections), alongside detailed, self-administered online questionnaires regarding sexual behaviors, adherence, and attitudes. Online weekly notes will be used to record pill use and sexual practice. Various measurements will be triangulated to assess adherence, including: self-reported adherence, pill count, and drug concentration. A propensity score matching model will be fitted to examine the effectiveness of PrEP use in HIV seroconversion compared with non-PrEP users selected from a local expanding cohort study of HIV-1-negative MSM at participating research centers. Analyses using a generalized estimating equation model will focus on elucidation of the cascade of PrEP implementation, effectiveness, safety, and possible effects of PrEP use on sexual behaviors. This study will provide a comprehensive assessment of real-world PrEP use among Chinese MSM, to develop guidelines and strategies for PrEP implementation in China.The CROPrEP project is the first study of the TDF/FTC combination as PrEP in China, which will provide primary data on PrEP implementation, including: the cascade of PrEP use, real-world effectiveness, adherence, and safety. The findings from this study have potential to be vital for promoting the integration of PrEP within the portfolio of HIV prevention interventions and developing guidance on PrEP implementation in China.ChiCTR-IIN-17013762 (Chinese Clinical Trial Registry). Date of registration: 8 December 2017." @default.
• W2967842372 created "2019-08-22" @default.
• W2967842372 creator A5001993330 @default.
• W2967842372 creator A5009508232 @default.
• W2967842372 creator A5014954540 @default.
• W2967842372 creator A5025536065 @default.
• W2967842372 creator A5044780027 @default.
• W2967842372 creator A5049494334 @default.
• W2967842372 creator A5053356699 @default.
• W2967842372 creator A5077095023 @default.
• W2967842372 creator A5078787260 @default.
• W2967842372 creator A5086076339 @default.
• W2967842372 creator A5086615075 @default.
• W2967842372 date "2019-08-15" @default.
• W2967842372 modified "2023-10-10" @default.
• W2967842372 title "Protocol for a multicenter, real-world study of HIV pre-exposure prophylaxis among men who have sex with men in China (CROPrEP)" @default.
• W2967842372 cites W1723966030 @default.
• W2967842372 cites W1994017454 @default.
• W2967842372 cites W2028751336 @default.
• W2967842372 cites W2068575612 @default.
• W2967842372 cites W2073986430 @default.
• W2967842372 cites W2103920597 @default.
• W2967842372 cites W2104239905 @default.
• W2967842372 cites W2150644408 @default.
• W2967842372 cites W2303717604 @default.
• W2967842372 cites W2319917590 @default.
• W2967842372 cites W2334371454 @default.
• W2967842372 cites W2492031659 @default.
• W2967842372 cites W2535418322 @default.
• W2967842372 cites W2738559785 @default.
• W2967842372 cites W2808761516 @default.
• W2967842372 cites W2812260391 @default.
• W2967842372 cites W2885344378 @default.
• W2967842372 cites W2900561809 @default.
• W2967842372 cites W2911824075 @default.
• W2967842372 doi "https://doi.org/10.1186/s12879-019-4355-y" @default.
• W2967842372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6694544" @default.
• W2967842372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31416439" @default.
• W2967842372 hasPublicationYear "2019" @default.
• W2967842372 type Work @default.
• W2967842372 sameAs 2967842372 @default.
• W2967842372 citedByCount "25" @default.
• W2967842372 countsByYear W29678423722020 @default.
• W2967842372 countsByYear W29678423722021 @default.
• W2967842372 countsByYear W29678423722022 @default.
• W2967842372 countsByYear W29678423722023 @default.
• W2967842372 crossrefType "journal-article" @default.
• W2967842372 hasAuthorship W2967842372A5001993330 @default.
• W2967842372 hasAuthorship W2967842372A5009508232 @default.
• W2967842372 hasAuthorship W2967842372A5014954540 @default.
• W2967842372 hasAuthorship W2967842372A5025536065 @default.
• W2967842372 hasAuthorship W2967842372A5044780027 @default.
• W2967842372 hasAuthorship W2967842372A5049494334 @default.
• W2967842372 hasAuthorship W2967842372A5053356699 @default.
• W2967842372 hasAuthorship W2967842372A5077095023 @default.
• W2967842372 hasAuthorship W2967842372A5078787260 @default.
• W2967842372 hasAuthorship W2967842372A5086076339 @default.
• W2967842372 hasAuthorship W2967842372A5086615075 @default.
• W2967842372 hasBestOaLocation W29678423721 @default.
• W2967842372 hasConcept C126322002 @default.
• W2967842372 hasConcept C142462285 @default.
• W2967842372 hasConcept C144024400 @default.
• W2967842372 hasConcept C149923435 @default.
• W2967842372 hasConcept C151730666 @default.
• W2967842372 hasConcept C2776939746 @default.
• W2967842372 hasConcept C2776983459 @default.
• W2967842372 hasConcept C2777288759 @default.
• W2967842372 hasConcept C2779343474 @default.
• W2967842372 hasConcept C2779379456 @default.
• W2967842372 hasConcept C2779496540 @default.
• W2967842372 hasConcept C2779778239 @default.
• W2967842372 hasConcept C2993143319 @default.
• W2967842372 hasConcept C3013748606 @default.
• W2967842372 hasConcept C512399662 @default.
• W2967842372 hasConcept C71924100 @default.
• W2967842372 hasConcept C81603835 @default.
• W2967842372 hasConcept C86803240 @default.
• W2967842372 hasConcept C98274493 @default.
• W2967842372 hasConceptScore W2967842372C126322002 @default.
• W2967842372 hasConceptScore W2967842372C142462285 @default.
• W2967842372 hasConceptScore W2967842372C144024400 @default.
• W2967842372 hasConceptScore W2967842372C149923435 @default.
• W2967842372 hasConceptScore W2967842372C151730666 @default.
• W2967842372 hasConceptScore W2967842372C2776939746 @default.
• W2967842372 hasConceptScore W2967842372C2776983459 @default.
• W2967842372 hasConceptScore W2967842372C2777288759 @default.
• W2967842372 hasConceptScore W2967842372C2779343474 @default.
• W2967842372 hasConceptScore W2967842372C2779379456 @default.
• W2967842372 hasConceptScore W2967842372C2779496540 @default.
• W2967842372 hasConceptScore W2967842372C2779778239 @default.
• W2967842372 hasConceptScore W2967842372C2993143319 @default.
• W2967842372 hasConceptScore W2967842372C3013748606 @default.
• W2967842372 hasConceptScore W2967842372C512399662 @default.
• W2967842372 hasConceptScore W2967842372C71924100 @default.
• W2967842372 hasConceptScore W2967842372C81603835 @default.
• W2967842372 hasConceptScore W2967842372C86803240 @default.
• W2967842372 hasConceptScore W2967842372C98274493 @default.
• W2967842372 hasFunder F4320321001 @default.
• W2967842372 hasIssue "1" @default.
• W2967842372 hasLocation W29678423721 @default.

• next