Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967843517> ?p ?o ?g. }
- W2967843517 endingPage "1934578X1986859" @default.
- W2967843517 startingPage "1934578X1986859" @default.
- W2967843517 abstract "Natural products, a rich source of bioactive chemical compounds, have served humans as a safer drug of choice since times. Eriocalyxin B, an ent-Kaurene diterpenoid, has been extracted from a traditional Chinese herb Isodon eriocalyx. Experimental data support the anticancer and anti-inflammatory activities of EriB. This natural entity exhibits anticancer effects against breast, pancreatic, leukemia, ovarian, lung, bladder, and colorectal cancer. EriB has capability to inhibit the proliferation of cancer cells by prompting apoptosis, arresting cell cycle, and modulating cell signaling pathways. The regulation of signaling pathways in cancerous cells by EriB involves the modulation of various apoptosis-related factors (Bak, Bax, caspases, XIAP, survivin, and Beclin-1), transcriptional factors (nuclear factor kappa B [NF-κB], STAT3, Janus-activated kinase 2, Notch, AP-1, and lκBα), enzymes (cyclooxygenase 2, matrix metalloproteinase 2 [MMP-2], MMP-9, and poly (ADP-ribose) polymerase), cytokines, and protein kinases (mitogen-activated protein kinase and ERK1/2). This review proposes that EriB supplies a novel opportunity for the cure of cancer but supplementary investigations along with preclinical trials are obligatory to effectively figure out its biological and pharmacological applications." @default.
- W2967843517 created "2019-08-22" @default.
- W2967843517 creator A5013268507 @default.
- W2967843517 creator A5015979602 @default.
- W2967843517 creator A5024636462 @default.
- W2967843517 creator A5029938851 @default.
- W2967843517 creator A5071035781 @default.
- W2967843517 creator A5072084552 @default.
- W2967843517 creator A5072337975 @default.
- W2967843517 creator A5075487751 @default.
- W2967843517 date "2019-08-01" @default.
- W2967843517 modified "2023-10-13" @default.
- W2967843517 title "Eriocalyxin B Biological Activity: A Review on Its Mechanism of Action" @default.
- W2967843517 cites W1487878063 @default.
- W2967843517 cites W1641464472 @default.
- W2967843517 cites W1739249602 @default.
- W2967843517 cites W1745634660 @default.
- W2967843517 cites W1965694039 @default.
- W2967843517 cites W1971473975 @default.
- W2967843517 cites W1998021298 @default.
- W2967843517 cites W2008757142 @default.
- W2967843517 cites W2009172813 @default.
- W2967843517 cites W2013726900 @default.
- W2967843517 cites W2017717232 @default.
- W2967843517 cites W2031084334 @default.
- W2967843517 cites W2032013348 @default.
- W2967843517 cites W2033588393 @default.
- W2967843517 cites W2036437770 @default.
- W2967843517 cites W2037855439 @default.
- W2967843517 cites W2041620837 @default.
- W2967843517 cites W2043892945 @default.
- W2967843517 cites W2047501409 @default.
- W2967843517 cites W2050429240 @default.
- W2967843517 cites W2054731801 @default.
- W2967843517 cites W2062289724 @default.
- W2967843517 cites W2074536742 @default.
- W2967843517 cites W2081871809 @default.
- W2967843517 cites W2086189875 @default.
- W2967843517 cites W2088094960 @default.
- W2967843517 cites W2090443219 @default.
- W2967843517 cites W2092313221 @default.
- W2967843517 cites W2102840492 @default.
- W2967843517 cites W2113142659 @default.
- W2967843517 cites W2113699832 @default.
- W2967843517 cites W2121135301 @default.
- W2967843517 cites W2122098990 @default.
- W2967843517 cites W2122226574 @default.
- W2967843517 cites W2123583425 @default.
- W2967843517 cites W2124685189 @default.
- W2967843517 cites W2125907821 @default.
- W2967843517 cites W2128073815 @default.
- W2967843517 cites W2140128301 @default.
- W2967843517 cites W2142641037 @default.
- W2967843517 cites W2143541289 @default.
- W2967843517 cites W2145181332 @default.
- W2967843517 cites W2146281269 @default.
- W2967843517 cites W2147798082 @default.
- W2967843517 cites W2163101003 @default.
- W2967843517 cites W2173413096 @default.
- W2967843517 cites W2259227633 @default.
- W2967843517 cites W2326823588 @default.
- W2967843517 cites W2469832905 @default.
- W2967843517 cites W2530719862 @default.
- W2967843517 cites W2591354127 @default.
- W2967843517 cites W2731134446 @default.
- W2967843517 cites W2771472591 @default.
- W2967843517 cites W2794483713 @default.
- W2967843517 cites W2803627340 @default.
- W2967843517 cites W2902521012 @default.
- W2967843517 cites W2903810676 @default.
- W2967843517 cites W393548907 @default.
- W2967843517 cites W4211019558 @default.
- W2967843517 cites W2792738243 @default.
- W2967843517 doi "https://doi.org/10.1177/1934578x19868598" @default.
- W2967843517 hasPublicationYear "2019" @default.
- W2967843517 type Work @default.
- W2967843517 sameAs 2967843517 @default.
- W2967843517 citedByCount "5" @default.
- W2967843517 countsByYear W29678435172020 @default.
- W2967843517 countsByYear W29678435172021 @default.
- W2967843517 crossrefType "journal-article" @default.
- W2967843517 hasAuthorship W2967843517A5013268507 @default.
- W2967843517 hasAuthorship W2967843517A5015979602 @default.
- W2967843517 hasAuthorship W2967843517A5024636462 @default.
- W2967843517 hasAuthorship W2967843517A5029938851 @default.
- W2967843517 hasAuthorship W2967843517A5071035781 @default.
- W2967843517 hasAuthorship W2967843517A5072084552 @default.
- W2967843517 hasAuthorship W2967843517A5072337975 @default.
- W2967843517 hasAuthorship W2967843517A5075487751 @default.
- W2967843517 hasBestOaLocation W29678435171 @default.
- W2967843517 hasConcept C100175707 @default.
- W2967843517 hasConcept C121608353 @default.
- W2967843517 hasConcept C184235292 @default.
- W2967843517 hasConcept C185592680 @default.
- W2967843517 hasConcept C190283241 @default.
- W2967843517 hasConcept C202751555 @default.
- W2967843517 hasConcept C2775975398 @default.
- W2967843517 hasConcept C2776120743 @default.