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• W2967866430 abstract "ABSTRACT Background Post-traumatic stress disorder (PTSD) has been reported to increase the risk for dementia in veterans and civilians. Conversely, case reports have described the delayed onset of PTSD in individuals developing dementia, suggesting a complex relationship between these two conditions. Objectives To critically review studies investigating the association between PTSD and dementia and to assess the evidence for a bidirectional relationship between the two conditions. Methods A systematic review of Web of Science Core databases was carried out from inception of databases up to November 2018 to identify observational studies pertaining to both PTSD and dementia. Populations enrolled, stressors and neuropathologies, and main outcomes of studies were extracted, in addition to age at trauma and at onset of PTSD and dementia. The different temporal relationships between trauma and onset of the conditions were characterized. Results Twenty-five articles were included in the review; 14 articles assessed the association of PTSD with subsequent dementia and 11 articles reported the delayed onset of PTSD with the onset of dementia. Most reported traumas occurred in early-life ( Conclusion Current evidence suggests that PTSD and dementia have a bidirectional relationship: PTSD increases the risk for late-onset dementia and dementia increases the risk for delayed-onset PTSD in those who experienced a significant trauma earlier in life." @default.
• W2967866430 created "2019-08-22" @default.
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• W2967866430 date "2020-01-01" @default.
• W2967866430 modified "2023-10-16" @default.
• W2967866430 title "The Interplay Between Post-traumatic Stress Disorder and Dementia: A Systematic Review" @default.
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• W2967866430 doi "https://doi.org/10.1016/j.jagp.2019.08.006" @default.
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