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• W2967883383 endingPage "190" @default.
• W2967883383 startingPage "169" @default.
• W2967883383 abstract "For many years, major differences in morphology, motility, and mechanical characteristics have been observed between transformed cancer and normal cells. In this review, we consider these differences as linked to different states of normal and transformed cells that involve distinct mechanosensing and motility pathways. There is a strong correlation between repeated tissue healing and/or inflammation and the probability of cancer, both of which involve growth in adult tissues. Many factors are likely needed to enable growth, including the loss of rigidity sensing, but recent evidence indicates that microRNAs have important roles in causing the depletion of growth-suppressing proteins. One microRNA, miR-21, is overexpressed in many different tissues during both healing and cancer. Normal cells can become transformed by the depletion of cytoskeletal proteins that results in the loss of mechanosensing, particularly rigidity sensing. Conversely, the transformed state can be reversed by the expression of cytoskeletal proteins—without direct alteration of hormone receptor levels. In this review, we consider the different stereotypical forms of motility and mechanosensory systems. A major difference between normal and transformed cells involves a sensitivity of transformed cells to mechanical perturbations. Thus, understanding the different mechanical characteristics of transformed cells may enable new approaches to treating wound healing and cancer." @default.
• W2967883383 created "2019-08-22" @default.
• W2967883383 creator A5040193425 @default.
• W2967883383 date "2019-10-06" @default.
• W2967883383 modified "2023-10-05" @default.
• W2967883383 title "A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing" @default.
• W2967883383 cites W1023837718 @default.
• W2967883383 cites W1068482264 @default.
• W2967883383 cites W1634092232 @default.
• W2967883383 cites W1931017125 @default.
• W2967883383 cites W1965878299 @default.
• W2967883383 cites W1966073555 @default.
• W2967883383 cites W1984414342 @default.
• W2967883383 cites W1985035975 @default.
• W2967883383 cites W1985944592 @default.
• W2967883383 cites W1987817703 @default.
• W2967883383 cites W1989095124 @default.
• W2967883383 cites W1991547734 @default.
• W2967883383 cites W1991954670 @default.
• W2967883383 cites W1995062036 @default.
• W2967883383 cites W1996757213 @default.
• W2967883383 cites W1999250555 @default.
• W2967883383 cites W2000159881 @default.
• W2967883383 cites W2000333351 @default.
• W2967883383 cites W2001812643 @default.
• W2967883383 cites W2002054030 @default.
• W2967883383 cites W2002371751 @default.
• W2967883383 cites W2003727694 @default.
• W2967883383 cites W2006558083 @default.
• W2967883383 cites W2006677222 @default.
• W2967883383 cites W2006695366 @default.
• W2967883383 cites W2008119136 @default.
• W2967883383 cites W2012801471 @default.
• W2967883383 cites W2023158200 @default.
• W2967883383 cites W2027196446 @default.
• W2967883383 cites W2031855642 @default.
• W2967883383 cites W2033881548 @default.
• W2967883383 cites W203862578 @default.
• W2967883383 cites W2041724231 @default.
• W2967883383 cites W2045140467 @default.
• W2967883383 cites W2049233086 @default.
• W2967883383 cites W2050169328 @default.
• W2967883383 cites W2050445063 @default.
• W2967883383 cites W2050612706 @default.
• W2967883383 cites W2053145461 @default.
• W2967883383 cites W2057989196 @default.
• W2967883383 cites W2060095036 @default.
• W2967883383 cites W2061511912 @default.
• W2967883383 cites W2069820450 @default.
• W2967883383 cites W2073400429 @default.
• W2967883383 cites W2079487506 @default.
• W2967883383 cites W2080260453 @default.
• W2967883383 cites W2089210429 @default.
• W2967883383 cites W2097381572 @default.
• W2967883383 cites W2109577572 @default.
• W2967883383 cites W2110578000 @default.
• W2967883383 cites W2111719518 @default.
• W2967883383 cites W2112451226 @default.
• W2967883383 cites W2113251343 @default.
• W2967883383 cites W2115205179 @default.
• W2967883383 cites W2117403796 @default.
• W2967883383 cites W2121545810 @default.
• W2967883383 cites W2122858192 @default.
• W2967883383 cites W2123496888 @default.
• W2967883383 cites W2132419064 @default.
• W2967883383 cites W2134208433 @default.
• W2967883383 cites W2140198882 @default.
• W2967883383 cites W2143258794 @default.
• W2967883383 cites W2146785599 @default.
• W2967883383 cites W2147288982 @default.
• W2967883383 cites W2151876618 @default.
• W2967883383 cites W2156193902 @default.
• W2967883383 cites W2158501218 @default.
• W2967883383 cites W2166167719 @default.
• W2967883383 cites W2178884288 @default.
• W2967883383 cites W2187651642 @default.
• W2967883383 cites W2191268037 @default.
• W2967883383 cites W2192354918 @default.
• W2967883383 cites W2205358880 @default.
• W2967883383 cites W2221790801 @default.
• W2967883383 cites W2239366013 @default.
• W2967883383 cites W2323044652 @default.
• W2967883383 cites W2336814020 @default.
• W2967883383 cites W2338269936 @default.
• W2967883383 cites W2374076407 @default.
• W2967883383 cites W2414012998 @default.
• W2967883383 cites W2468572787 @default.
• W2967883383 cites W2482940721 @default.
• W2967883383 cites W2491393351 @default.
• W2967883383 cites W2512859624 @default.
• W2967883383 cites W2515196970 @default.
• W2967883383 cites W2517382426 @default.
• W2967883383 cites W2532618553 @default.
• W2967883383 cites W2538277817 @default.
• W2967883383 cites W2546222148 @default.
• W2967883383 cites W2548576115 @default.
• W2967883383 cites W2556969059 @default.
• W2967883383 cites W2570023565 @default.

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