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• W2967931898 abstract "A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non-coding regions of the genome. Single-nucleotide polymorphisms (SNPs) in the 5ʹ untranslated region (5ʹ-UTR) of the ferritin light chain ( FTL ) gene that cause hyperferritinemia are reported to disrupt translation repression by altering iron regulatory protein (IRP) interactions with the FTL mRNA 5ʹ-UTR. Here, we show that human eukaryotic translation initiation factor 3 (eIF3) acts as a distinct repressor of FTL mRNA translation, and eIF3-mediated FTL repression is disrupted by a subset of SNPs in FTL that cause hyperferritinemia. These results identify a direct role for eIF3-mediated translational control in a specific human disease." @default.
• W2967931898 created "2019-08-22" @default.
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• W2967931898 date "2019-08-15" @default.
• W2967931898 modified "2023-09-27" @default.
• W2967931898 title "Repression of ferritin light chain translation by human eIF3" @default.
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• W2967931898 doi "https://doi.org/10.7554/elife.48193" @default.
• W2967931898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721798" @default.
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• W2967931898 hasPublicationYear "2019" @default.
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