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• W2967939012 abstract "Abstract Although bariatric surgery is approved for a woman of child-bearing age with an interest in subsequent pregnancy, reports of in utero growth issues during pregnancy have garnered a closer look at the impact of maternal surgical weight loss on the pre- and postpartum periods. Offspring of dams having received vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have increased risk for metabolic syndrome later in life. Here, we aimed to determine whether the postnatal catch-up growth trajectory of bariatric offspring may be affected by milk composition. Milk samples were collected at postnatal day 15/16 from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG), Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk obtained from H-VSG dams had elevated glucose ( P < 0.05) and significantly reduced triglyceride content ( P < 0.01). Milk from H-Sham dams had the lowest amount of milk protein ( P < 0.05). Fatty acid composition measured by fractionation was largely not affected by surgery but rather maternal diet. No difference was observed in milk leptin levels; however, insulin, adiponectin, and growth hormone levels were significantly increased in milk from H-VSG animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG dams suggests that milk composition could be a factor in reducing the rate of growth during the lactation period." @default.
• W2967939012 created "2019-08-22" @default.
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• W2967939012 date "2019-08-09" @default.
• W2967939012 modified "2023-10-15" @default.
• W2967939012 title "Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery" @default.
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• W2967939012 doi "https://doi.org/10.1017/s2040174419000424" @default.
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