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- W2967948443 endingPage "115043" @default.
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- W2967948443 abstract "High-throughput screening of small-molecule libraries has led to the identification of thiadiazoles as a new class of inhibitors against Staphylococcus aureus sortase A (SrtA). N-(5-((4-nitrobenzyl)thio)-1,3,4-thiadiazol-2-yl)nicotinamide (IC50 = 3.8 µM) was identified as a potent inhibitor of SrtA after synthetic modification of hit compounds. Additional ligands developed in this study displayed affinities in the low micromolar range without affecting bacterial growth in vitro. The study also suggest a new mode of action through covalent binding to the active site cysteine." @default.
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- W2967948443 date "2019-10-01" @default.
- W2967948443 modified "2023-09-27" @default.
- W2967948443 title "Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A" @default.
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- W2967948443 doi "https://doi.org/10.1016/j.bmc.2019.115043" @default.
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