Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967949879> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2967949879 endingPage "2837" @default.
- W2967949879 startingPage "2837" @default.
- W2967949879 abstract "2837 The immune system plays an important role in eliminating tumors. Accordingly, many immunotherapy protocols have been developed in attempts to boost anti-tumor immune responses in cancer patients. In clinical trials performed to date, however, little correlation has been observed between parameters measured to assess cellular immune responses and clinical outcome. Moreover, when whole-cell vaccines are used, the ambiguity of the immunogenic antigen adds to the complexity of analysis, since it is not clear which components of the immune system contribute more to a favourable immune response. In this study, we have monitored the frequency of monocytes, B-cells, NK-cells, regulatory T-cells and different effector and memory T-cell subsets in cancer patients before and after vaccination with a proprietary allogeneic whole tumor cell line vaccine. Antigen-experienced T-cells can be divided into functionally distinct populations, according to the expression of different cell surface markers, such as CD45RA, CCR7, CD27 and CD28. Using 10-color flow cytometry, we subdivided circulating CD4+ and CD8+ effector memory (EM) (CCR7-,CD45RA-) and TEMRA (CCR7-, CD45RA+) cells according to their surface expression of CD27 and CD28, as well as CD57, a marker up-regulated on very late-differentiated T-cells. Significant alterations were only observed in the T-cell compartment, whereas the frequency of monocytes, B-cells and NK-cells remained unchanged. In both CD4 and CD8 cells, clinical responders but not non-responders showed significant decreases in central memory (CM) (CCR7+ CD45RA-) and a subset of EM (CD27+ CD28+, least differentiated, or EM1) cells (P=0.02 to 0.004). No other differences in any of the above mentioned T-cell subsets were observed. However, the numbers of T regulatory cells, defined as strongly staining for CD4, CD25 and Foxp3, but weakly for CD127, were more highly significantly reduced in responders (P=0.0002) but not non-responders (NS) than any other T cell subsets. These findings indicate better correlation of T regulatory cell subset reductions with clinical responses following vaccination than with changes in any other T cell subsets and emphasis the importance of T regulatory cell status for clinical outcome of immunotherapy. This work was supported by EC-LSHG-CT-2007-036894 “LifeSpan”, DFG-SFB685-B4 and DFG-PA 361-11/1." @default.
- W2967949879 created "2019-08-22" @default.
- W2967949879 creator A5027331206 @default.
- W2967949879 creator A5039824028 @default.
- W2967949879 creator A5063812788 @default.
- W2967949879 creator A5084323082 @default.
- W2967949879 date "2008-05-01" @default.
- W2967949879 modified "2023-09-26" @default.
- W2967949879 title "Monitoring subpopulations of CD4+ and CD8+ effector/memory and T regulatory cells in cancer patients: correlations with post-vaccination clinical responses." @default.
- W2967949879 hasPublicationYear "2008" @default.
- W2967949879 type Work @default.
- W2967949879 sameAs 2967949879 @default.
- W2967949879 citedByCount "0" @default.
- W2967949879 crossrefType "journal-article" @default.
- W2967949879 hasAuthorship W2967949879A5027331206 @default.
- W2967949879 hasAuthorship W2967949879A5039824028 @default.
- W2967949879 hasAuthorship W2967949879A5063812788 @default.
- W2967949879 hasAuthorship W2967949879A5084323082 @default.
- W2967949879 hasConcept C129374314 @default.
- W2967949879 hasConcept C147483822 @default.
- W2967949879 hasConcept C148125776 @default.
- W2967949879 hasConcept C154317977 @default.
- W2967949879 hasConcept C167672396 @default.
- W2967949879 hasConcept C202751555 @default.
- W2967949879 hasConcept C203014093 @default.
- W2967949879 hasConcept C2776090121 @default.
- W2967949879 hasConcept C2777701055 @default.
- W2967949879 hasConcept C2780674031 @default.
- W2967949879 hasConcept C502942594 @default.
- W2967949879 hasConcept C55493867 @default.
- W2967949879 hasConcept C79484868 @default.
- W2967949879 hasConcept C86803240 @default.
- W2967949879 hasConcept C8891405 @default.
- W2967949879 hasConceptScore W2967949879C129374314 @default.
- W2967949879 hasConceptScore W2967949879C147483822 @default.
- W2967949879 hasConceptScore W2967949879C148125776 @default.
- W2967949879 hasConceptScore W2967949879C154317977 @default.
- W2967949879 hasConceptScore W2967949879C167672396 @default.
- W2967949879 hasConceptScore W2967949879C202751555 @default.
- W2967949879 hasConceptScore W2967949879C203014093 @default.
- W2967949879 hasConceptScore W2967949879C2776090121 @default.
- W2967949879 hasConceptScore W2967949879C2777701055 @default.
- W2967949879 hasConceptScore W2967949879C2780674031 @default.
- W2967949879 hasConceptScore W2967949879C502942594 @default.
- W2967949879 hasConceptScore W2967949879C55493867 @default.
- W2967949879 hasConceptScore W2967949879C79484868 @default.
- W2967949879 hasConceptScore W2967949879C86803240 @default.
- W2967949879 hasConceptScore W2967949879C8891405 @default.
- W2967949879 hasLocation W29679498791 @default.
- W2967949879 hasOpenAccess W2967949879 @default.
- W2967949879 hasPrimaryLocation W29679498791 @default.
- W2967949879 hasRelatedWork W1559484537 @default.
- W2967949879 hasRelatedWork W1983476016 @default.
- W2967949879 hasRelatedWork W2026549861 @default.
- W2967949879 hasRelatedWork W2163718404 @default.
- W2967949879 hasRelatedWork W2201717251 @default.
- W2967949879 hasRelatedWork W2465981864 @default.
- W2967949879 hasRelatedWork W2534448206 @default.
- W2967949879 hasRelatedWork W2551952866 @default.
- W2967949879 hasRelatedWork W2586731491 @default.
- W2967949879 hasRelatedWork W2587203419 @default.
- W2967949879 hasRelatedWork W2755232834 @default.
- W2967949879 hasRelatedWork W2927171417 @default.
- W2967949879 hasRelatedWork W2979612756 @default.
- W2967949879 hasRelatedWork W3033278954 @default.
- W2967949879 hasRelatedWork W3093622051 @default.
- W2967949879 hasRelatedWork W3099323318 @default.
- W2967949879 hasRelatedWork W3146293900 @default.
- W2967949879 hasRelatedWork W3154212591 @default.
- W2967949879 hasRelatedWork W3164552881 @default.
- W2967949879 hasRelatedWork W2141595302 @default.
- W2967949879 hasVolume "68" @default.
- W2967949879 isParatext "false" @default.
- W2967949879 isRetracted "false" @default.
- W2967949879 magId "2967949879" @default.
- W2967949879 workType "article" @default.