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- W2967959962 endingPage "e0007650" @default.
- W2967959962 startingPage "e0007650" @default.
- W2967959962 abstract "Enteric fevers, caused by the Salmonella enterica serovars Typhi (ST), Paratyphi A (PA) and Paratyphi B (PB), are life-threatening illnesses exhibiting very similar clinical symptoms but with distinct epidemiologies, geographical distributions and susceptibilities to antimicrobial treatment. Nevertheless, the mechanisms by which the host recognizes pathogens with high levels of homology, such as these bacterial serovars, remain poorly understood. Using a three-dimensional organotypic model of the human intestinal mucosa and PA, PB, and ST, we observed significant differences in the secretion patterns of pro-inflammatory cytokines and chemokines elicited by these serovars. These cytokines/chemokines were likely to be co-regulated and influenced the function of epithelial cells, such as the production of IL-8. We also found differing levels of polymorphonuclear leukocyte (PMN) migration among various infection conditions that either included or excluded lymphocytes and macrophages (Mϕ), strongly suggesting feedback mechanisms among these cells. Blocking experiments showed that IL-1β, IL-6, IL-8, TNF-α and CCL3 cytokines were involved in the differential regulation of migration patterns. We conclude that the crosstalk among the lymphocytes, Mϕ, PMN and epithelial cells is cytokine/chemokine-dependent and bacterial-serotype specific, and plays a pivotal role in orchestrating the functional efficiency of the innate cells and migratory characteristics of the leukocytes." @default.
- W2967959962 created "2019-08-22" @default.
- W2967959962 creator A5014946608 @default.
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- W2967959962 date "2019-08-14" @default.
- W2967959962 modified "2023-10-17" @default.
- W2967959962 title "Crosstalk between leukocytes triggers differential immune responses against Salmonella enterica serovars Typhi and Paratyphi" @default.
- W2967959962 cites W110004853 @default.
- W2967959962 cites W1270657610 @default.
- W2967959962 cites W1484319464 @default.
- W2967959962 cites W1515681057 @default.
- W2967959962 cites W1549389235 @default.
- W2967959962 cites W1772589807 @default.
- W2967959962 cites W179217223 @default.
- W2967959962 cites W1964976921 @default.
- W2967959962 cites W1970094669 @default.
- W2967959962 cites W1974702731 @default.
- W2967959962 cites W1977213133 @default.
- W2967959962 cites W1978319180 @default.
- W2967959962 cites W1984303884 @default.
- W2967959962 cites W1994646972 @default.
- W2967959962 cites W1995418070 @default.
- W2967959962 cites W1999413229 @default.
- W2967959962 cites W2005391965 @default.
- W2967959962 cites W2006687695 @default.
- W2967959962 cites W2008720858 @default.
- W2967959962 cites W2009676802 @default.
- W2967959962 cites W2040711587 @default.
- W2967959962 cites W2046892194 @default.
- W2967959962 cites W2051456508 @default.
- W2967959962 cites W2052630412 @default.
- W2967959962 cites W2054026897 @default.
- W2967959962 cites W2054841400 @default.
- W2967959962 cites W2062695479 @default.
- W2967959962 cites W2063698423 @default.
- W2967959962 cites W2063909583 @default.
- W2967959962 cites W2065565273 @default.
- W2967959962 cites W2067180295 @default.
- W2967959962 cites W2071484066 @default.
- W2967959962 cites W2080528409 @default.
- W2967959962 cites W2080789350 @default.
- W2967959962 cites W2085355903 @default.
- W2967959962 cites W2093530163 @default.
- W2967959962 cites W2096283660 @default.
- W2967959962 cites W2096608095 @default.
- W2967959962 cites W2102898060 @default.
- W2967959962 cites W2104299175 @default.
- W2967959962 cites W2107153626 @default.
- W2967959962 cites W2109518418 @default.
- W2967959962 cites W2120891749 @default.
- W2967959962 cites W2121466479 @default.
- W2967959962 cites W2122292170 @default.
- W2967959962 cites W2123230168 @default.
- W2967959962 cites W2132030430 @default.
- W2967959962 cites W2132294879 @default.
- W2967959962 cites W2137272926 @default.
- W2967959962 cites W2139462981 @default.
- W2967959962 cites W2142999073 @default.
- W2967959962 cites W2145188627 @default.
- W2967959962 cites W2145449723 @default.
- W2967959962 cites W2148749933 @default.
- W2967959962 cites W2154823630 @default.
- W2967959962 cites W2156189327 @default.
- W2967959962 cites W2159217327 @default.
- W2967959962 cites W2163806416 @default.
- W2967959962 cites W2271281533 @default.
- W2967959962 cites W2336871771 @default.
- W2967959962 cites W2338409233 @default.
- W2967959962 cites W2342602767 @default.
- W2967959962 cites W2402243697 @default.
- W2967959962 cites W2418279095 @default.
- W2967959962 cites W2503218735 @default.
- W2967959962 cites W2521004414 @default.
- W2967959962 cites W2593353559 @default.
- W2967959962 cites W2594732596 @default.
- W2967959962 cites W2596984373 @default.
- W2967959962 cites W2611874711 @default.
- W2967959962 cites W2754292666 @default.
- W2967959962 cites W2769807777 @default.
- W2967959962 cites W2787508009 @default.
- W2967959962 cites W2791016534 @default.
- W2967959962 cites W2793652542 @default.
- W2967959962 cites W2892506948 @default.
- W2967959962 cites W2899348400 @default.
- W2967959962 cites W39104836 @default.
- W2967959962 cites W4211065633 @default.
- W2967959962 cites W4243637892 @default.
- W2967959962 cites W4320301113 @default.
- W2967959962 cites W72881935 @default.
- W2967959962 doi "https://doi.org/10.1371/journal.pntd.0007650" @default.
- W2967959962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6709971" @default.
- W2967959962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31412039" @default.
- W2967959962 hasPublicationYear "2019" @default.
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