FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967960092> ?p ?o ?g. }

• W2967960092 endingPage "5099" @default.
• W2967960092 startingPage "5099" @default.
• W2967960092 abstract "5099 Melanoma is notorious for affecting young and middle-aged people, unlike most other solid tumors, which mainly affect older adults. Therapy for early disease is primarily surgery, with a minor benefit noted with adjuvant therapy; however, there is no effective treatment for advanced disease because of lack of effective treatment modalities. CXCL-8, a member of the CXC chemokine family, is constitutively expressed in malignant melanoma and functions as an autocrine/paracrine growth, invasive and angiogenic factor. Our recent data demonstrate that modulation of CXCR1 or CXCR2 expression in melanoma cells regulates CXCL-8-dependent growth, angiogenesis and motility. The precise functional significance of these receptors in malignant melanoma growth and angiogenesis is hitherto unclear. Thus, theobjective of this study is to determine the functional roles of CXCR1 and CXCR2 in CXCL-8-dependent melanoma growth and angiogenesis. We knocked-down CXCR1 or CXCR2 expression by using mammalian expression vectors (pSuper.neo) constitutively expressing short hairpin (sh)RNA for CXCR1 or CXCR2. A375SM malignant melanoma cells were transfected with pCXCR1-sh1 or pCXCR2-sh1 and were stably selected and analyzed for CXCR1 and CXCR2 expression. We observed a significant decrease in CXCR1 and CXCR2 expression in A375SM-CXCR1sh1 and A375SM-CXCR2sh1 knock-down cells respectively, compared to control cells. We examined whether knock-down of CXCR1 or CXCR2 modulates cellular phenotypes associated with melanoma growth, angiogenesis and metastasis. We observed decreases in CXCL-8 induced cell proliferation, survival, chemotaxis, invasion and actin reorganization in melanoma cells knocked-down for CXCR1 or CXCR2 as compared to control cells. Furthermore, when A375SM-CXCR1sh1, A375SM-CXCR2sh1 and A375SM-control cells were injected subcutaneously into nude mice, tumor growth was significantly inhibited in both A375SM-CXCR1sh1, A375SM-CXCR2sh1 tumors compared to control tumors. In addition, we observed a significant decrease in cell proliferation, survival and neovascularization in CXCR1 or CXCR2 knock-down tumors as compared to control tumors. In conclusion, our study provides experimental evidence that supports the functional significance of CXCR1 and CXCR2 in the regulation of human malignant melanoma and in addition, suggests the development of strategies that target both receptors." @default.
• W2967960092 created "2019-08-22" @default.
• W2967960092 creator A5033322099 @default.
• W2967960092 creator A5051129825 @default.
• W2967960092 creator A5054926074 @default.
• W2967960092 date "2008-05-01" @default.
• W2967960092 modified "2023-09-23" @default.
• W2967960092 title "CXCR1 or CXCR2 knock-down inhibits cellular proliferation, survival, motility and tumor growth in human malignant melanoma" @default.
• W2967960092 hasPublicationYear "2008" @default.
• W2967960092 type Work @default.
• W2967960092 sameAs 2967960092 @default.
• W2967960092 citedByCount "0" @default.
• W2967960092 crossrefType "journal-article" @default.
• W2967960092 hasAuthorship W2967960092A5033322099 @default.
• W2967960092 hasAuthorship W2967960092A5051129825 @default.
• W2967960092 hasAuthorship W2967960092A5054926074 @default.
• W2967960092 hasConcept C121608353 @default.
• W2967960092 hasConcept C12823836 @default.
• W2967960092 hasConcept C128240485 @default.
• W2967960092 hasConcept C13373296 @default.
• W2967960092 hasConcept C137738243 @default.
• W2967960092 hasConcept C170493617 @default.
• W2967960092 hasConcept C173396325 @default.
• W2967960092 hasConcept C190232843 @default.
• W2967960092 hasConcept C203014093 @default.
• W2967960092 hasConcept C2776914184 @default.
• W2967960092 hasConcept C2777658100 @default.
• W2967960092 hasConcept C2779013556 @default.
• W2967960092 hasConcept C2780394083 @default.
• W2967960092 hasConcept C502942594 @default.
• W2967960092 hasConcept C54355233 @default.
• W2967960092 hasConcept C55493867 @default.
• W2967960092 hasConcept C58207958 @default.
• W2967960092 hasConcept C62112901 @default.
• W2967960092 hasConcept C71924100 @default.
• W2967960092 hasConcept C7876069 @default.
• W2967960092 hasConcept C81885089 @default.
• W2967960092 hasConcept C84913492 @default.
• W2967960092 hasConcept C86803240 @default.
• W2967960092 hasConcept C95444343 @default.
• W2967960092 hasConceptScore W2967960092C121608353 @default.
• W2967960092 hasConceptScore W2967960092C12823836 @default.
• W2967960092 hasConceptScore W2967960092C128240485 @default.
• W2967960092 hasConceptScore W2967960092C13373296 @default.
• W2967960092 hasConceptScore W2967960092C137738243 @default.
• W2967960092 hasConceptScore W2967960092C170493617 @default.
• W2967960092 hasConceptScore W2967960092C173396325 @default.
• W2967960092 hasConceptScore W2967960092C190232843 @default.
• W2967960092 hasConceptScore W2967960092C203014093 @default.
• W2967960092 hasConceptScore W2967960092C2776914184 @default.
• W2967960092 hasConceptScore W2967960092C2777658100 @default.
• W2967960092 hasConceptScore W2967960092C2779013556 @default.
• W2967960092 hasConceptScore W2967960092C2780394083 @default.
• W2967960092 hasConceptScore W2967960092C502942594 @default.
• W2967960092 hasConceptScore W2967960092C54355233 @default.
• W2967960092 hasConceptScore W2967960092C55493867 @default.
• W2967960092 hasConceptScore W2967960092C58207958 @default.
• W2967960092 hasConceptScore W2967960092C62112901 @default.
• W2967960092 hasConceptScore W2967960092C71924100 @default.
• W2967960092 hasConceptScore W2967960092C7876069 @default.
• W2967960092 hasConceptScore W2967960092C81885089 @default.
• W2967960092 hasConceptScore W2967960092C84913492 @default.
• W2967960092 hasConceptScore W2967960092C86803240 @default.
• W2967960092 hasConceptScore W2967960092C95444343 @default.
• W2967960092 hasLocation W29679600921 @default.
• W2967960092 hasOpenAccess W2967960092 @default.
• W2967960092 hasPrimaryLocation W29679600921 @default.
• W2967960092 hasRelatedWork W1978658896 @default.
• W2967960092 hasRelatedWork W1986950357 @default.
• W2967960092 hasRelatedWork W1990893819 @default.
• W2967960092 hasRelatedWork W2009970570 @default.
• W2967960092 hasRelatedWork W2040776944 @default.
• W2967960092 hasRelatedWork W2047013291 @default.
• W2967960092 hasRelatedWork W2077175445 @default.
• W2967960092 hasRelatedWork W2077443884 @default.
• W2967960092 hasRelatedWork W2140193755 @default.
• W2967960092 hasRelatedWork W2168338978 @default.
• W2967960092 hasRelatedWork W2169259150 @default.
• W2967960092 hasRelatedWork W2170037266 @default.
• W2967960092 hasRelatedWork W2284463183 @default.
• W2967960092 hasRelatedWork W2326565837 @default.
• W2967960092 hasRelatedWork W2609392152 @default.
• W2967960092 hasRelatedWork W2726649836 @default.
• W2967960092 hasRelatedWork W2745185376 @default.
• W2967960092 hasRelatedWork W2894176893 @default.
• W2967960092 hasRelatedWork W2896933938 @default.
• W2967960092 hasRelatedWork W2979967583 @default.
• W2967960092 hasVolume "68" @default.
• W2967960092 isParatext "false" @default.
• W2967960092 isRetracted "false" @default.
• W2967960092 magId "2967960092" @default.
• W2967960092 workType "article" @default.