Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967983292> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2967983292 abstract "Abstract Emodin has a variety of pharmacological functions including anti-bacterial infection, anti-inflammatory, anti-oxidation, anti-tumor, regulation of gastrointestinal activities and anti-hepatic and lung fibrosis. However, the role of emodin in the regulation of renal interstitial fibrosis(RIF) remains poorly understood. In this study, we investigated the regulation of emodin in RIF and revealed the underlying molecular mechanisms. We established a unilateral ureter obstruction(UUO) model to simulate renal interstitial fibrosis in rats. We found that UUO rats were observed a large amount of inflammatory cell infiltration, more fibroblast proliferation, collagen fiber proliferation. Furthermore, we demonstrated that the up-regulation of TIMP1 and down-regulation of MMP9 were related to renal fibrosis. However, those phenomena in emodin-treated UUO rats were ameliorated. Collectively, our results provide new insights into the treatment of RIF and suggest that the TIMP1/MM9 signaling axis may be a potential therapeutic target for RIF." @default.
- W2967983292 created "2019-08-22" @default.
- W2967983292 creator A5002509297 @default.
- W2967983292 creator A5014752731 @default.
- W2967983292 creator A5017282605 @default.
- W2967983292 creator A5044688218 @default.
- W2967983292 creator A5051046606 @default.
- W2967983292 creator A5074988980 @default.
- W2967983292 date "2019-08-15" @default.
- W2967983292 modified "2023-09-27" @default.
- W2967983292 title "Emodin Attenuates Renal Interstitial Fibrosis via Regulation of TIMP1/MM9 Pathway in Rats" @default.
- W2967983292 cites W1969512119 @default.
- W2967983292 cites W1982976290 @default.
- W2967983292 cites W1993196935 @default.
- W2967983292 cites W2066544997 @default.
- W2967983292 cites W2078657995 @default.
- W2967983292 cites W2106004568 @default.
- W2967983292 cites W2537789979 @default.
- W2967983292 cites W2576066242 @default.
- W2967983292 cites W2776273511 @default.
- W2967983292 cites W2778815600 @default.
- W2967983292 cites W2781731141 @default.
- W2967983292 cites W2809667088 @default.
- W2967983292 cites W2888464338 @default.
- W2967983292 cites W2888812846 @default.
- W2967983292 cites W2889524763 @default.
- W2967983292 doi "https://doi.org/10.1101/736876" @default.
- W2967983292 hasPublicationYear "2019" @default.
- W2967983292 type Work @default.
- W2967983292 sameAs 2967983292 @default.
- W2967983292 citedByCount "0" @default.
- W2967983292 crossrefType "posted-content" @default.
- W2967983292 hasAuthorship W2967983292A5002509297 @default.
- W2967983292 hasAuthorship W2967983292A5014752731 @default.
- W2967983292 hasAuthorship W2967983292A5017282605 @default.
- W2967983292 hasAuthorship W2967983292A5044688218 @default.
- W2967983292 hasAuthorship W2967983292A5051046606 @default.
- W2967983292 hasAuthorship W2967983292A5074988980 @default.
- W2967983292 hasBestOaLocation W29679832921 @default.
- W2967983292 hasConcept C104317684 @default.
- W2967983292 hasConcept C127561419 @default.
- W2967983292 hasConcept C142724271 @default.
- W2967983292 hasConcept C150194340 @default.
- W2967983292 hasConcept C185592680 @default.
- W2967983292 hasConcept C202751555 @default.
- W2967983292 hasConcept C2775997469 @default.
- W2967983292 hasConcept C2778248515 @default.
- W2967983292 hasConcept C2780381497 @default.
- W2967983292 hasConcept C2780559512 @default.
- W2967983292 hasConcept C2780692422 @default.
- W2967983292 hasConcept C502942594 @default.
- W2967983292 hasConcept C55493867 @default.
- W2967983292 hasConcept C71924100 @default.
- W2967983292 hasConcept C98274493 @default.
- W2967983292 hasConceptScore W2967983292C104317684 @default.
- W2967983292 hasConceptScore W2967983292C127561419 @default.
- W2967983292 hasConceptScore W2967983292C142724271 @default.
- W2967983292 hasConceptScore W2967983292C150194340 @default.
- W2967983292 hasConceptScore W2967983292C185592680 @default.
- W2967983292 hasConceptScore W2967983292C202751555 @default.
- W2967983292 hasConceptScore W2967983292C2775997469 @default.
- W2967983292 hasConceptScore W2967983292C2778248515 @default.
- W2967983292 hasConceptScore W2967983292C2780381497 @default.
- W2967983292 hasConceptScore W2967983292C2780559512 @default.
- W2967983292 hasConceptScore W2967983292C2780692422 @default.
- W2967983292 hasConceptScore W2967983292C502942594 @default.
- W2967983292 hasConceptScore W2967983292C55493867 @default.
- W2967983292 hasConceptScore W2967983292C71924100 @default.
- W2967983292 hasConceptScore W2967983292C98274493 @default.
- W2967983292 hasLocation W29679832921 @default.
- W2967983292 hasOpenAccess W2967983292 @default.
- W2967983292 hasPrimaryLocation W29679832921 @default.
- W2967983292 hasRelatedWork W2028295328 @default.
- W2967983292 hasRelatedWork W2142383829 @default.
- W2967983292 hasRelatedWork W2238378374 @default.
- W2967983292 hasRelatedWork W2512293447 @default.
- W2967983292 hasRelatedWork W2529186916 @default.
- W2967983292 hasRelatedWork W2739059057 @default.
- W2967983292 hasRelatedWork W2765215896 @default.
- W2967983292 hasRelatedWork W2766708789 @default.
- W2967983292 hasRelatedWork W2781731141 @default.
- W2967983292 hasRelatedWork W2889050155 @default.
- W2967983292 hasRelatedWork W2891619543 @default.
- W2967983292 hasRelatedWork W2891629413 @default.
- W2967983292 hasRelatedWork W2919845093 @default.
- W2967983292 hasRelatedWork W2921692877 @default.
- W2967983292 hasRelatedWork W3006594003 @default.
- W2967983292 hasRelatedWork W3026767583 @default.
- W2967983292 hasRelatedWork W3109183101 @default.
- W2967983292 hasRelatedWork W3112794916 @default.
- W2967983292 hasRelatedWork W3117764498 @default.
- W2967983292 hasRelatedWork W3118018628 @default.
- W2967983292 isParatext "false" @default.
- W2967983292 isRetracted "false" @default.
- W2967983292 magId "2967983292" @default.
- W2967983292 workType "article" @default.