Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967994476> ?p ?o ?g. }
- W2967994476 endingPage "24950" @default.
- W2967994476 startingPage "24942" @default.
- W2967994476 abstract "A series of novel chalcone derivatives containing a thiophene sulfonate group were designed and synthesized. The structures of all title compounds were determined by 1H-NMR, 13C-NMR and HRMS. Antibacterial bioassays indicated that, compound 2l demonstrated excellent antibacterial activities against Xanthomonas axonopodis pv. citri (Xac), with an EC50 value of 11.4 μg mL-1, which is significantly superior to those of bismerthiazol (BT) (51.6 μg mL-1) and thiodiazole-copper (TC) (94.7 μg mL-1). Meanwhile, the mechanism of action of compound 2l was confirmed by using scanning electron microscopy (SEM). In addition, compound 2e showed remarkable inactivation activity against Tobacco mosaic virus (TMV), with an EC50 value of 44.3 μg mL-1, which was superior to that of ningnanmycin (120.6 μg mL-1). Microscale thermophoresis (MST) also showed that the binding of compounds 2e and 2h to Tobacco mosaic virus coat protein (TMV-CP) yielded Kd values of 0.270 and 0.301 μmol L-1, which are better than that of ningnanmycin (0.596 μmol L-1). At the same time, molecular docking studies for 2e and 2h with TMV-CP (PDB code: 1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP in each case. These results suggested that chalcone derivatives containing a thiophene sulfonate group may be considered as activators in the design of antibacterial and antiviral agents." @default.
- W2967994476 created "2019-08-22" @default.
- W2967994476 creator A5003413234 @default.
- W2967994476 creator A5015625878 @default.
- W2967994476 creator A5022412215 @default.
- W2967994476 creator A5027358797 @default.
- W2967994476 creator A5056609542 @default.
- W2967994476 creator A5060589362 @default.
- W2967994476 creator A5077367725 @default.
- W2967994476 creator A5091645862 @default.
- W2967994476 date "2019-01-01" @default.
- W2967994476 modified "2023-10-12" @default.
- W2967994476 title "Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate" @default.
- W2967994476 cites W1553773232 @default.
- W2967994476 cites W1969826763 @default.
- W2967994476 cites W1976342627 @default.
- W2967994476 cites W1984805002 @default.
- W2967994476 cites W1985728245 @default.
- W2967994476 cites W1989369576 @default.
- W2967994476 cites W1991256251 @default.
- W2967994476 cites W1993319308 @default.
- W2967994476 cites W2002478917 @default.
- W2967994476 cites W2009066742 @default.
- W2967994476 cites W2028270779 @default.
- W2967994476 cites W2030016120 @default.
- W2967994476 cites W2035288807 @default.
- W2967994476 cites W2047314897 @default.
- W2967994476 cites W2070822454 @default.
- W2967994476 cites W2070847201 @default.
- W2967994476 cites W2076246766 @default.
- W2967994476 cites W2078056443 @default.
- W2967994476 cites W2086299421 @default.
- W2967994476 cites W2090482702 @default.
- W2967994476 cites W2092601148 @default.
- W2967994476 cites W2107614328 @default.
- W2967994476 cites W2146103350 @default.
- W2967994476 cites W2152433359 @default.
- W2967994476 cites W2170593228 @default.
- W2967994476 cites W2238762542 @default.
- W2967994476 cites W2314556883 @default.
- W2967994476 cites W2332570042 @default.
- W2967994476 cites W2341455807 @default.
- W2967994476 cites W2342850408 @default.
- W2967994476 cites W2344952161 @default.
- W2967994476 cites W2431388246 @default.
- W2967994476 cites W2530739119 @default.
- W2967994476 cites W2543279754 @default.
- W2967994476 cites W2547951732 @default.
- W2967994476 cites W2560192379 @default.
- W2967994476 cites W2602929741 @default.
- W2967994476 cites W2605194124 @default.
- W2967994476 cites W2610790488 @default.
- W2967994476 cites W2758618425 @default.
- W2967994476 cites W2765584030 @default.
- W2967994476 cites W2789758300 @default.
- W2967994476 cites W2800783354 @default.
- W2967994476 cites W2801388991 @default.
- W2967994476 cites W2810978359 @default.
- W2967994476 cites W2887914987 @default.
- W2967994476 cites W2902532303 @default.
- W2967994476 cites W2919299589 @default.
- W2967994476 doi "https://doi.org/10.1039/c9ra05349b" @default.
- W2967994476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35528674" @default.
- W2967994476 hasPublicationYear "2019" @default.
- W2967994476 type Work @default.
- W2967994476 sameAs 2967994476 @default.
- W2967994476 citedByCount "29" @default.
- W2967994476 countsByYear W29679944762020 @default.
- W2967994476 countsByYear W29679944762021 @default.
- W2967994476 countsByYear W29679944762022 @default.
- W2967994476 countsByYear W29679944762023 @default.
- W2967994476 crossrefType "journal-article" @default.
- W2967994476 hasAuthorship W2967994476A5003413234 @default.
- W2967994476 hasAuthorship W2967994476A5015625878 @default.
- W2967994476 hasAuthorship W2967994476A5022412215 @default.
- W2967994476 hasAuthorship W2967994476A5027358797 @default.
- W2967994476 hasAuthorship W2967994476A5056609542 @default.
- W2967994476 hasAuthorship W2967994476A5060589362 @default.
- W2967994476 hasAuthorship W2967994476A5077367725 @default.
- W2967994476 hasAuthorship W2967994476A5091645862 @default.
- W2967994476 hasBestOaLocation W29679944761 @default.
- W2967994476 hasConcept C13965031 @default.
- W2967994476 hasConcept C144707691 @default.
- W2967994476 hasConcept C159047783 @default.
- W2967994476 hasConcept C178790620 @default.
- W2967994476 hasConcept C185592680 @default.
- W2967994476 hasConcept C202751555 @default.
- W2967994476 hasConcept C2522874641 @default.
- W2967994476 hasConcept C2778894819 @default.
- W2967994476 hasConcept C2779953032 @default.
- W2967994476 hasConcept C2780104969 @default.
- W2967994476 hasConcept C2780764945 @default.
- W2967994476 hasConcept C523546767 @default.
- W2967994476 hasConcept C537181965 @default.
- W2967994476 hasConcept C54355233 @default.
- W2967994476 hasConcept C55493867 @default.
- W2967994476 hasConcept C71240020 @default.
- W2967994476 hasConcept C86803240 @default.