FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2967994815> ?p ?o ?g. }

• W2967994815 endingPage "76" @default.
• W2967994815 startingPage "76" @default.
• W2967994815 abstract "Histoplasmosis is an important cause of mortality in people with advanced HIV, especially in countries with limited access to diagnostic assays. Histoplasmosis can be diagnosed using culture, histopathology, and antibody, antigen, and molecular assays. Several factors may affect the analytical performance of these laboratory assays, including sample type, clinical stage of the disease, and previous use of antifungal treatment, among others. Here we describe the results of a systematic literature review, followed by a meta-analysis of the analytical performances of the diagnostic laboratory assays employed. Our initial search identified 1631 references, of which 1559 references were excluded after title and abstract screening, leaving 72 references identified as studies relevant to the validation of histoplasmosis diagnostic assays. After evaluating the full text, 30 studies were selected for final review, including one paper not identified in the initial search. The meta-analysis for assay analytical performance shows the following results for the overall sensitivity (Sen) and specificity (Spe) of the various methods evaluated: Culture, Sen 77% (no data for specificity calculation); antibody detection assays, Sen 58%/Spe 100%; antigen detection assays, Sen 95%/Spe 97%; and DNA detection assays (molecular), Sen 95%/Spe 99%. Of the 30 studies reviewed, nearly half (n = 13) evaluated Histoplasma antigen assays, which were determined to be the most accurate methodology for diagnosis of progressive disseminated histoplasmosis in advanced HIV (inverse of the negative likelihood ratio was 13.2). Molecular assays appear promising for accurate diagnosis of histoplasmosis, but consensus on exact techniques is needed. Cultures showed variable sensitivity related to sample type and laboratory handling. Finally, antibody assays presented high specificity but low sensitivity. This poor sensitivity is most likely due the highly immunosuppressed state of this patient population. Diagnostic assays are crucial for accurate diagnosis of progressive disseminated histoplasmosis (PDH) with advanced HIV disease." @default.
• W2967994815 created "2019-08-22" @default.
• W2967994815 creator A5032479064 @default.
• W2967994815 creator A5034735444 @default.
• W2967994815 creator A5061438399 @default.
• W2967994815 creator A5087985337 @default.
• W2967994815 date "2019-08-18" @default.
• W2967994815 modified "2023-10-07" @default.
• W2967994815 title "Diagnosis of Progressive Disseminated Histoplasmosis in Advanced HIV: A Meta-Analysis of Assay Analytical Performance" @default.
• W2967994815 cites W1519254653 @default.
• W2967994815 cites W162923522 @default.
• W2967994815 cites W1695905849 @default.
• W2967994815 cites W1978391605 @default.
• W2967994815 cites W1991632990 @default.
• W2967994815 cites W1999660009 @default.
• W2967994815 cites W2002171130 @default.
• W2967994815 cites W2002815032 @default.
• W2967994815 cites W2006765105 @default.
• W2967994815 cites W2018280064 @default.
• W2967994815 cites W2018547758 @default.
• W2967994815 cites W2020789506 @default.
• W2967994815 cites W2032347383 @default.
• W2967994815 cites W2034613197 @default.
• W2967994815 cites W2071183922 @default.
• W2967994815 cites W2073681763 @default.
• W2967994815 cites W2079635795 @default.
• W2967994815 cites W2105482448 @default.
• W2967994815 cites W2110538662 @default.
• W2967994815 cites W2111561507 @default.
• W2967994815 cites W2114629213 @default.
• W2967994815 cites W2120944337 @default.
• W2967994815 cites W2122808643 @default.
• W2967994815 cites W2142062901 @default.
• W2967994815 cites W2142065432 @default.
• W2967994815 cites W2142323855 @default.
• W2967994815 cites W2147077015 @default.
• W2967994815 cites W2147703072 @default.
• W2967994815 cites W2155499873 @default.
• W2967994815 cites W2156098321 @default.
• W2967994815 cites W2162100991 @default.
• W2967994815 cites W2166734004 @default.
• W2967994815 cites W2199537915 @default.
• W2967994815 cites W2258854409 @default.
• W2967994815 cites W2396820016 @default.
• W2967994815 cites W2468996569 @default.
• W2967994815 cites W2478919472 @default.
• W2967994815 cites W2592669197 @default.
• W2967994815 cites W2615679760 @default.
• W2967994815 cites W2623566795 @default.
• W2967994815 cites W2786508841 @default.
• W2967994815 cites W2793520088 @default.
• W2967994815 cites W2888696104 @default.
• W2967994815 cites W2900156895 @default.
• W2967994815 cites W2903975741 @default.
• W2967994815 cites W2904561605 @default.
• W2967994815 cites W2912524286 @default.
• W2967994815 cites W2913456134 @default.
• W2967994815 doi "https://doi.org/10.3390/jof5030076" @default.
• W2967994815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6787751" @default.
• W2967994815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31426618" @default.
• W2967994815 hasPublicationYear "2019" @default.
• W2967994815 type Work @default.
• W2967994815 sameAs 2967994815 @default.
• W2967994815 citedByCount "40" @default.
• W2967994815 countsByYear W29679948152019 @default.
• W2967994815 countsByYear W29679948152020 @default.
• W2967994815 countsByYear W29679948152021 @default.
• W2967994815 countsByYear W29679948152022 @default.
• W2967994815 countsByYear W29679948152023 @default.
• W2967994815 crossrefType "journal-article" @default.
• W2967994815 hasAuthorship W2967994815A5032479064 @default.
• W2967994815 hasAuthorship W2967994815A5034735444 @default.
• W2967994815 hasAuthorship W2967994815A5061438399 @default.
• W2967994815 hasAuthorship W2967994815A5087985337 @default.
• W2967994815 hasBestOaLocation W29679948151 @default.
• W2967994815 hasConcept C142724271 @default.
• W2967994815 hasConcept C147483822 @default.
• W2967994815 hasConcept C159047783 @default.
• W2967994815 hasConcept C203014093 @default.
• W2967994815 hasConcept C2777802930 @default.
• W2967994815 hasConcept C2778803964 @default.
• W2967994815 hasConcept C2780318139 @default.
• W2967994815 hasConcept C71924100 @default.
• W2967994815 hasConcept C86803240 @default.
• W2967994815 hasConcept C95190672 @default.
• W2967994815 hasConceptScore W2967994815C142724271 @default.
• W2967994815 hasConceptScore W2967994815C147483822 @default.
• W2967994815 hasConceptScore W2967994815C159047783 @default.
• W2967994815 hasConceptScore W2967994815C203014093 @default.
• W2967994815 hasConceptScore W2967994815C2777802930 @default.
• W2967994815 hasConceptScore W2967994815C2778803964 @default.
• W2967994815 hasConceptScore W2967994815C2780318139 @default.
• W2967994815 hasConceptScore W2967994815C71924100 @default.
• W2967994815 hasConceptScore W2967994815C86803240 @default.
• W2967994815 hasConceptScore W2967994815C95190672 @default.
• W2967994815 hasIssue "3" @default.
• W2967994815 hasLocation W29679948151 @default.
• W2967994815 hasLocation W29679948152 @default.

• next