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- W2967996986 abstract "Abstract Aims This prospective study aimed to determine the proportions of therapeutic inertia when treatment targets not achieved in adults T2D at three public health clinics in Malaysia. Methods The index prescriptions were those when the annual blood tests were reviewed. Prescriptions were verified and classified as 1) no change, 2) stepping up and 3) stepping down. Multivariable logistic regression and sensitive analyses were conducted. Results At follow-up, 552 participants were available for the assessment of therapeutic inertia (78.9% response rate). The mean (SD) age and diabetes duration were 60.0 (9.9) years and 5.0 (6.0) years, respectively. High therapeutic inertia were observed in oral anti-diabetic (61-72%), anti-hypertensive (34-65%) and lipid-lowering therapies (56-77%), and lesser in insulin (34- 52%). Insulin therapeutic inertia was more likely among those with shorter diabetes duration (adjusted OR 0.9, 95% CI 0.87, 0.98). Those who did not achieve treatment targets were less likely to experience therapeutic inertia: HbA1c ≥ 7.0%: adjusted OR 0.10 (0.04, 0.24); BP ≥ 140/90 mmHg: 0.28 (0.16, 0.50); LDL-cholesterol ≥ 2.6 mmol/L: 0.37 (0.22, 0.64). Conclusions Although therapeutic intensifications were more likely in the present of non- achieved treatment targets but the proportions of therapeutic inertia were high. Trial registration NCT02730754 https://clinicaltrials.gov/ct2/show/NCT02730754 Highlights Probably the first study in Malaysia or Asian countries Assessing three main therapeutic inertia among T2D at primary diabetes care Proportions of therapeutic inertia were high Therapeutic inertia was unlikely in non-achieved treatment targets Possible causes of therapeutic inertia require identification and rectification" @default.
- W2967996986 created "2019-08-22" @default.
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- W2967996986 date "2019-07-19" @default.
- W2967996986 modified "2023-09-23" @default.
- W2967996986 title "Is therapeutic inertia present in primary diabetes care in Malaysia? A prospective study" @default.
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- W2967996986 doi "https://doi.org/10.1101/19002584" @default.
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