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• W2968014044 abstract "Jasonia glutinosa (L.) DC., known as rock tea (RT), is traditionally used in Spain as a digestive due to its beneficial properties in bowel disorders. The pharmacological nature of these properties has not been established yet. The aim of this work was to evaluate the therapeutic utility of RT in experimental colitis and to identify chemical constituents with anti-inflammatory and/or anti-oxidative properties. RT extract was prepared with ethanol in a Soxhlet apparatus and analysed by HPLC–DAD. Superoxide radical scavenging properties, xanthine oxidase and lipoxygenase (5-LOX) inhibitory activity, and capability to lower nitric oxide (NO) and tumor necrosis factor α (TNF-α) levels were measured in cell-free and cell-based assays. In the 2.5%-dextran-sodium sulphate (DSS) injury-repair model of ulcerative colitis (UC), mice were daily treated with sulfasalazine (SSZ, as reference drug, 100 mg/kg bw), RT (5, 25 and 50 mg/kg bw, p.o.), or vehicle over 20 days. Colitis was scored daily. Colon samples were examined macroscopically and histopathologically. Protein levels of myeloperoxidase (MPO), interleukins 6, and 10 (IL-6, IL-10), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2) were studied as markers of oxidative stress and inflammatory activity. The integrity of the apical epithelial layer was assessed by immunofluorescence staining of zonula ocludens-1 (ZO-1). Finally, intestinal contractility was also evaluated by isometric myography. Fifteen phenolic compounds and three pigments were identified and quantified, of which caffeoylquinic acids, and the flavonoid, quercetin-3-O-galactoside, were the most abundant. RT extract significantly scavenged superoxide radicals, inhibited 5-LOX activity, and lowered NO and TNF-α levels. DSS-treated mice receiving RT scored clinically lower than controls during the first 3 days of DSS treatment and during the recovery period. SSZ was less effective than RT. Anatomical and histological examination of colon samples revealed that RT significantly prevented colon shortening, increased colon thickness, and lowered the macroscopic damage score. RT also significantly prevented the increase of MPO activity, IL-6 levels, iNOS and COX-2 expression, the loss of ZO-1 apical expression, and normalized contractility disturbances. In conclusion, daily administration of RT showed therapeutic properties in the DSS-model of UC. The benefits of RT can likely be attributed to its anti-inflammatory and antioxidant phenolic and flavonoid constituents." @default.
• W2968014044 created "2019-08-22" @default.
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• W2968014044 date "2019-08-13" @default.
• W2968014044 modified "2023-10-18" @default.
• W2968014044 title "Jasonia glutinosa (L.) DC., a traditional herbal medicine, reduces inflammation, oxidative stress and protects the intestinal barrier in a murine model of colitis" @default.
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• W2968014044 cites W1979948289 @default.
• W2968014044 cites W1986943820 @default.
• W2968014044 cites W1989506542 @default.
• W2968014044 cites W1992843650 @default.
• W2968014044 cites W1994616470 @default.
• W2968014044 cites W2002082297 @default.
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• W2968014044 cites W2013851125 @default.
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• W2968014044 cites W2026607868 @default.
• W2968014044 cites W2027894434 @default.
• W2968014044 cites W2032043476 @default.
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• W2968014044 cites W2132915170 @default.
• W2968014044 cites W2145515127 @default.
• W2968014044 cites W2156687777 @default.
• W2968014044 cites W2161789287 @default.
• W2968014044 cites W2164315961 @default.
• W2968014044 cites W2166435632 @default.
• W2968014044 cites W2169920462 @default.
• W2968014044 cites W2170125726 @default.
• W2968014044 cites W2216606325 @default.
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• W2968014044 doi "https://doi.org/10.1007/s10787-019-00626-0" @default.
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• W2968014044 hasPublicationYear "2019" @default.
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