FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968045241> ?p ?o ?g. }

• W2968045241 endingPage "1968" @default.
• W2968045241 startingPage "1962" @default.
• W2968045241 abstract "Abstract Background Intravenous colistin is widely used to treat infections in pediatric patients. Unfortunately, there is a paucity of pharmacological information to guide the selection of dosage regimens. The daily dose recommended by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) is the same body weight–based dose traditionally used in adults. The aim was to increase our understanding of the patient factors that influence the plasma concentration of colistin, and assess the likely appropriateness of the FDA and EMA dosage recommendations. Methods There were 5 patients, with a median age of 1.75 (range 0.1–6.25) years, a median weight of 10.7 (2.9–21.5) kg, and a median creatinine clearance of 179 (44–384) mL/min/1.73m2, who received intravenous infusions of colistimethate each 8 hours. The median daily dose was 0.21 (0.20–0.21) million international units/kg, equivalent to 6.8 (6.5–6.9) mg of colistin base activity per kg/day. Plasma concentrations of colistimethate and formed colistin were subjected to population pharmacokinetic modeling to explore the patient factors influencing the concentration of colistin. Results The median, average, steady-state plasma concentration of colistin (Css,avg) was 0.88 mg/L; individual values ranged widely (0.41–3.50 mg/L), even though all patients received the same body weight–based daily dose. Although the daily doses were ~33% above the upper limit of the FDA- and EMA-recommended dose range, only 2 patients achieved Css,avg ≥2mg/L; the remaining 3 patients had Css,avg <1mg/L. The pharmacokinetic covariate analysis revealed that clearances of colistimethate and colistin were related to creatinine clearance. Conclusions The FDA and EMA dosage recommendations may be suboptimal for many pediatric patients. Renal functioning is an important determinant of dosing in these patients." @default.
• W2968045241 created "2019-08-22" @default.
• W2968045241 creator A5020720635 @default.
• W2968045241 creator A5027667556 @default.
• W2968045241 creator A5030691636 @default.
• W2968045241 creator A5052883326 @default.
• W2968045241 creator A5073046394 @default.
• W2968045241 creator A5078517503 @default.
• W2968045241 date "2019-01-26" @default.
• W2968045241 modified "2023-09-25" @default.
• W2968045241 title "Population Pharmacokinetics of Intravenous Colistin in Pediatric Patients: Implications for the Selection of Dosage Regimens" @default.
• W2968045241 cites W1556078719 @default.
• W2968045241 cites W1959456820 @default.
• W2968045241 cites W1966483053 @default.
• W2968045241 cites W1967967495 @default.
• W2968045241 cites W1982446827 @default.
• W2968045241 cites W2050947530 @default.
• W2968045241 cites W2053985319 @default.
• W2968045241 cites W2062595051 @default.
• W2968045241 cites W2063508616 @default.
• W2968045241 cites W2070283117 @default.
• W2968045241 cites W2092667376 @default.
• W2968045241 cites W2100773669 @default.
• W2968045241 cites W2102732904 @default.
• W2968045241 cites W2106185460 @default.
• W2968045241 cites W2117277409 @default.
• W2968045241 cites W2118734761 @default.
• W2968045241 cites W2120409679 @default.
• W2968045241 cites W2164032940 @default.
• W2968045241 cites W2168502103 @default.
• W2968045241 cites W2203490562 @default.
• W2968045241 cites W2245659112 @default.
• W2968045241 cites W2278118849 @default.
• W2968045241 cites W2286127041 @default.
• W2968045241 cites W2326502420 @default.
• W2968045241 cites W2527705259 @default.
• W2968045241 cites W2558313252 @default.
• W2968045241 cites W2715022910 @default.
• W2968045241 cites W2720648878 @default.
• W2968045241 cites W2748918315 @default.
• W2968045241 cites W2755559441 @default.
• W2968045241 cites W2775079536 @default.
• W2968045241 cites W2783773236 @default.
• W2968045241 cites W2789087362 @default.
• W2968045241 cites W2799473242 @default.
• W2968045241 doi "https://doi.org/10.1093/cid/ciz067" @default.
• W2968045241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30722017" @default.
• W2968045241 hasPublicationYear "2019" @default.
• W2968045241 type Work @default.
• W2968045241 sameAs 2968045241 @default.
• W2968045241 citedByCount "16" @default.
• W2968045241 countsByYear W29680452412019 @default.
• W2968045241 countsByYear W29680452412020 @default.
• W2968045241 countsByYear W29680452412021 @default.
• W2968045241 countsByYear W29680452412022 @default.
• W2968045241 countsByYear W29680452412023 @default.
• W2968045241 crossrefType "journal-article" @default.
• W2968045241 hasAuthorship W2968045241A5020720635 @default.
• W2968045241 hasAuthorship W2968045241A5027667556 @default.
• W2968045241 hasAuthorship W2968045241A5030691636 @default.
• W2968045241 hasAuthorship W2968045241A5052883326 @default.
• W2968045241 hasAuthorship W2968045241A5073046394 @default.
• W2968045241 hasAuthorship W2968045241A5078517503 @default.
• W2968045241 hasConcept C112705442 @default.
• W2968045241 hasConcept C126322002 @default.
• W2968045241 hasConcept C147583825 @default.
• W2968045241 hasConcept C2779259085 @default.
• W2968045241 hasConcept C2780035454 @default.
• W2968045241 hasConcept C2780306776 @default.
• W2968045241 hasConcept C2908647359 @default.
• W2968045241 hasConcept C501593827 @default.
• W2968045241 hasConcept C71924100 @default.
• W2968045241 hasConcept C86803240 @default.
• W2968045241 hasConcept C89423630 @default.
• W2968045241 hasConcept C98274493 @default.
• W2968045241 hasConcept C99454951 @default.
• W2968045241 hasConceptScore W2968045241C112705442 @default.
• W2968045241 hasConceptScore W2968045241C126322002 @default.
• W2968045241 hasConceptScore W2968045241C147583825 @default.
• W2968045241 hasConceptScore W2968045241C2779259085 @default.
• W2968045241 hasConceptScore W2968045241C2780035454 @default.
• W2968045241 hasConceptScore W2968045241C2780306776 @default.
• W2968045241 hasConceptScore W2968045241C2908647359 @default.
• W2968045241 hasConceptScore W2968045241C501593827 @default.
• W2968045241 hasConceptScore W2968045241C71924100 @default.
• W2968045241 hasConceptScore W2968045241C86803240 @default.
• W2968045241 hasConceptScore W2968045241C89423630 @default.
• W2968045241 hasConceptScore W2968045241C98274493 @default.
• W2968045241 hasConceptScore W2968045241C99454951 @default.
• W2968045241 hasIssue "11" @default.
• W2968045241 hasLocation W29680452411 @default.
• W2968045241 hasLocation W29680452412 @default.
• W2968045241 hasOpenAccess W2968045241 @default.
• W2968045241 hasPrimaryLocation W29680452411 @default.
• W2968045241 hasRelatedWork W1499958231 @default.
• W2968045241 hasRelatedWork W1969876219 @default.
• W2968045241 hasRelatedWork W1978032370 @default.
• W2968045241 hasRelatedWork W1979757582 @default.

• next