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- W2968045803 abstract "Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). Specifically, virally derived dsRNA is recognized and cleaved by the enzyme Dicer2 into short interfering RNAs (siRNAs), which further direct sequence-specific RNA silencing, ultimately silencing replication of the virus. Notably, RNAi can also be artificially triggered by the delivery of gene-specific dsRNA, thereby leading to endogenous gene silencing. This is a widely used technology that holds great potential to contribute to novel pest control strategies. In this regard, research efforts have been set to find methods to efficiently trigger RNAi in the field. In this article, we demonstrate the generation of dsRNA- and/or virus-derived siRNAs—the main RNAi effectors—in six insect species belonging to five economically important orders (Lepidoptera, Orthoptera, Hymenoptera, Coleoptera, and Diptera). In addition, we describe that the siRNA length distribution is species-dependent. Taken together, our results reveal interspecies variability in the (antiviral) RNAi mechanism in insects and show promise to contribute to future research on (viral-based) RNAi-triggering mechanisms in this class of animals." @default.
- W2968045803 created "2019-08-22" @default.
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- W2968045803 date "2019-08-11" @default.
- W2968045803 modified "2023-10-15" @default.
- W2968045803 title "Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects" @default.
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- W2968045803 doi "https://doi.org/10.3390/v11080738" @default.
- W2968045803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6723321" @default.
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