FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968047990> ?p ?o ?g. }

• W2968047990 endingPage "2468" @default.
• W2968047990 startingPage "2458" @default.
• W2968047990 abstract "Cell division orientation plays an essential role in tissue morphogenesis and cell fate decision. Recent studies showed that either cell shape or adhesion geometry can regulate the orientation of mitotic spindles and thereby the cell division orientation. However, how they together regulate the spindle orientation remains largely unclear. In this work, we use a general computational model to investigate the competitive mechanism of determining the spindle orientation between cell shape and intercellular adhesion in epithelial cells. We find the spindle orientation is dominated by the intercellular adhesion when the cell shape anisotropy is small, but dominated by the cell shape when the shape anisotropy is large. A strong adhesion and moderate adhesive size can ensure the planar division of epithelial cells with large apico-basal elongation. We also find the spindle orientation could be perpendicular to the adhesive region when only one side of the cell is adhered to an E-cadherin–coated matrix. But after the cell is compressed, the spindle orientation is governed by the cell shape and the spindle will be parallel to the adhesive region when the cell shape anisotropy is large. Finally, we demonstrate the competition between cell shape and tricellular junctions can also effectively regulate the spindle orientation." @default.
• W2968047990 created "2019-08-22" @default.
• W2968047990 creator A5053992324 @default.
• W2968047990 creator A5072203139 @default.
• W2968047990 creator A5088073999 @default.
• W2968047990 date "2019-09-01" @default.
• W2968047990 modified "2023-09-30" @default.
• W2968047990 title "Cell shape and intercellular adhesion regulate mitotic spindle orientation" @default.
• W2968047990 cites W1973017365 @default.
• W2968047990 cites W1976522797 @default.
• W2968047990 cites W1984932592 @default.
• W2968047990 cites W1994337091 @default.
• W2968047990 cites W2002315827 @default.
• W2968047990 cites W2007858577 @default.
• W2968047990 cites W2008852196 @default.
• W2968047990 cites W2024086086 @default.
• W2968047990 cites W2024686059 @default.
• W2968047990 cites W2031818488 @default.
• W2968047990 cites W2034301798 @default.
• W2968047990 cites W2038970717 @default.
• W2968047990 cites W2040152751 @default.
• W2968047990 cites W2043415140 @default.
• W2968047990 cites W2044889275 @default.
• W2968047990 cites W2045602393 @default.
• W2968047990 cites W2045823500 @default.
• W2968047990 cites W2045843159 @default.
• W2968047990 cites W2048176813 @default.
• W2968047990 cites W2054940555 @default.
• W2968047990 cites W2071439887 @default.
• W2968047990 cites W2079986203 @default.
• W2968047990 cites W2081589050 @default.
• W2968047990 cites W2084168227 @default.
• W2968047990 cites W2091498962 @default.
• W2968047990 cites W2093702766 @default.
• W2968047990 cites W2101286203 @default.
• W2968047990 cites W2113137123 @default.
• W2968047990 cites W2117279934 @default.
• W2968047990 cites W2120891538 @default.
• W2968047990 cites W2122986837 @default.
• W2968047990 cites W2125538185 @default.
• W2968047990 cites W2130217713 @default.
• W2968047990 cites W2131593986 @default.
• W2968047990 cites W2138378914 @default.
• W2968047990 cites W2140211952 @default.
• W2968047990 cites W2141251844 @default.
• W2968047990 cites W2147819429 @default.
• W2968047990 cites W2151801027 @default.
• W2968047990 cites W2152969835 @default.
• W2968047990 cites W2162802670 @default.
• W2968047990 cites W2167127135 @default.
• W2968047990 cites W2171939937 @default.
• W2968047990 cites W2172926635 @default.
• W2968047990 cites W2197395322 @default.
• W2968047990 cites W2228989826 @default.
• W2968047990 cites W2259936593 @default.
• W2968047990 cites W2267299509 @default.
• W2968047990 cites W2279410194 @default.
• W2968047990 cites W2280256316 @default.
• W2968047990 cites W2437181714 @default.
• W2968047990 cites W2489562715 @default.
• W2968047990 cites W2529418719 @default.
• W2968047990 cites W2564287288 @default.
• W2968047990 cites W2567413041 @default.
• W2968047990 cites W2588959863 @default.
• W2968047990 cites W2605969740 @default.
• W2968047990 cites W2610964855 @default.
• W2968047990 cites W2724850827 @default.
• W2968047990 cites W2767149653 @default.
• W2968047990 cites W2793774855 @default.
• W2968047990 cites W2888185577 @default.
• W2968047990 cites W2889404125 @default.
• W2968047990 cites W2902971662 @default.
• W2968047990 cites W2935444460 @default.
• W2968047990 cites W2952657883 @default.
• W2968047990 doi "https://doi.org/10.1091/mbc.e19-04-0227" @default.
• W2968047990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6743358" @default.
• W2968047990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31411941" @default.
• W2968047990 hasPublicationYear "2019" @default.
• W2968047990 type Work @default.
• W2968047990 sameAs 2968047990 @default.
• W2968047990 citedByCount "26" @default.
• W2968047990 countsByYear W29680479902019 @default.
• W2968047990 countsByYear W29680479902020 @default.
• W2968047990 countsByYear W29680479902021 @default.
• W2968047990 countsByYear W29680479902022 @default.
• W2968047990 countsByYear W29680479902023 @default.
• W2968047990 crossrefType "journal-article" @default.
• W2968047990 hasAuthorship W2968047990A5053992324 @default.
• W2968047990 hasAuthorship W2968047990A5072203139 @default.
• W2968047990 hasAuthorship W2968047990A5088073999 @default.
• W2968047990 hasBestOaLocation W29680479901 @default.
• W2968047990 hasConcept C104317684 @default.
• W2968047990 hasConcept C12554922 @default.
• W2968047990 hasConcept C1491633281 @default.
• W2968047990 hasConcept C149402561 @default.
• W2968047990 hasConcept C159985019 @default.
• W2968047990 hasConcept C192562407 @default.
• W2968047990 hasConcept C40692019 @default.

• next