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• W2968053511 endingPage "066023" @default.
• W2968053511 startingPage "066023" @default.
• W2968053511 abstract "Optogenetics provides a means to probe functional connections between brain areas. By activating a set of presynaptic neurons and recording the activity from a downstream brain area, one can establish the sign and strength of a feedforward connection. One challenge is that there are virtually limitless patterns that can be used to stimulate a presynaptic brain area. Functional influences on downstream brain areas can depend not just on whether presynaptic neurons were activated, but how they were activated. Corticofugal axons from the auditory cortex (ACtx) heavily innervate the auditory tectum, the inferior colliculus (IC). Here, we sought to determine whether different modes of corticocollicular activation could titrate the strength of feedforward modulation of sound processing in IC neurons.We used multi-channel electrophysiology and optogenetics to record from multiple regions of the IC in awake head-fixed mice while optogenetically stimulating ACtx neurons expressing Chronos, an ultra-fast channelrhodopsin. To identify cortical activation patterns associated with the strongest effects on IC firing rates, we employed a closed-loop evolutionary optimization procedure that tailored the voltage command signal sent to the laser based on spike feedback from single IC neurons.Within minutes, our evolutionary search procedure converged on ACtx stimulation configurations that produced more effective and widespread enhancement of IC unit activity than generic activation parameters. Cortical modulation of midbrain spiking was bi-directional, as the evolutionary search procedure could be programmed to converge on activation patterns that either suppressed or enhanced sound-evoked IC firing rate.This study introduces a closed-loop optimization procedure to probe functional connections between brain areas. Our findings demonstrate that the influence of descending feedback projections on subcortical sensory processing can vary both in sign and degree depending on how cortical neurons are activated in time." @default.
• W2968053511 created "2019-08-22" @default.
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• W2968053511 date "2019-10-29" @default.
• W2968053511 modified "2023-10-13" @default.
• W2968053511 title "Optimizing optogenetic stimulation protocols in auditory corticofugal neurons based on closed-loop spike feedback" @default.
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• W2968053511 doi "https://doi.org/10.1088/1741-2552/ab39cf" @default.
• W2968053511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6956656" @default.
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• W2968053511 hasPublicationYear "2019" @default.
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