FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968059887> ?p ?o ?g. }

• W2968059887 abstract "Neuroengineering methods can be effectively used in the design of new approaches to treat central nervous system and brain injury caused by neurotrauma, ischaemia or neurodegenerative disorders. During the last decade, significant results were achieved in the field of implant (scaffold) development using various biocompatible and biodegradable materials carrying neuronal cells for implantation into the injury site of the brain to repair its function. Neurons derived from animal or human induced pluripotent stem (iPS) cells are expected to be an ideal cell source, and induction methods for specific cell types have been actively studied to improve efficacy and specificity. A critical goal of neuro-regeneration is structural and functional restoration of the injury site. The target treatment area has heterogeneous and complex network topology with various types of cells that need to be restored with similar neuronal network structure to recover correct functionality. However, current scaffold-based technology for brain implants operates with homogeneous neuronal cell distribution, which limits recovery in the damaged area of the brain and prevents a return to fully functional biological tissue. In this study, we present a neuroengineering concept for designing a neural circuit with a pre-defined unidirectional network architecture that provides a balance of excitation/inhibition in the scaffold to form tissue similar to that in the injured area using various types of iPS cells. Such tissue will mimic the surrounding niche in the injured site and will morphologically and topologically integrate into the brain, recovering lost function." @default.
• W2968059887 created "2019-08-22" @default.
• W2968059887 creator A5002285448 @default.
• W2968059887 creator A5022406055 @default.
• W2968059887 creator A5030749207 @default.
• W2968059887 creator A5031898190 @default.
• W2968059887 creator A5032635092 @default.
• W2968059887 creator A5036511331 @default.
• W2968059887 creator A5056784071 @default.
• W2968059887 creator A5056817341 @default.
• W2968059887 creator A5062525214 @default.
• W2968059887 creator A5063291869 @default.
• W2968059887 creator A5065654448 @default.
• W2968059887 creator A5084931025 @default.
• W2968059887 creator A5090447356 @default.
• W2968059887 date "2019-08-29" @default.
• W2968059887 modified "2023-10-16" @default.
• W2968059887 title "Functional Scaffolding for Brain Implants: Engineered Neuronal Network by Microfabrication and iPSC Technology" @default.
• W2968059887 cites W1080082248 @default.
• W2968059887 cites W1136909202 @default.
• W2968059887 cites W1529448825 @default.
• W2968059887 cites W1980477804 @default.
• W2968059887 cites W1999287295 @default.
• W2968059887 cites W2004698106 @default.
• W2968059887 cites W2014286106 @default.
• W2968059887 cites W2021044878 @default.
• W2968059887 cites W2022235653 @default.
• W2968059887 cites W2027396705 @default.
• W2968059887 cites W2034579441 @default.
• W2968059887 cites W2052137502 @default.
• W2968059887 cites W2056734624 @default.
• W2968059887 cites W2071904606 @default.
• W2968059887 cites W2078315494 @default.
• W2968059887 cites W2095025631 @default.
• W2968059887 cites W2097722670 @default.
• W2968059887 cites W2100419378 @default.
• W2968059887 cites W2105445038 @default.
• W2968059887 cites W2107156550 @default.
• W2968059887 cites W2114079854 @default.
• W2968059887 cites W2121289914 @default.
• W2968059887 cites W2146693559 @default.
• W2968059887 cites W2147219189 @default.
• W2968059887 cites W2160775632 @default.
• W2968059887 cites W2170226075 @default.
• W2968059887 cites W2278295022 @default.
• W2968059887 cites W2302418890 @default.
• W2968059887 cites W2318035006 @default.
• W2968059887 cites W2343809842 @default.
• W2968059887 cites W2552293135 @default.
• W2968059887 cites W2601350462 @default.
• W2968059887 cites W2780341471 @default.
• W2968059887 cites W2785624401 @default.
• W2968059887 cites W2791833844 @default.
• W2968059887 cites W2799445331 @default.
• W2968059887 cites W2800220813 @default.
• W2968059887 cites W2885484867 @default.
• W2968059887 cites W2886831719 @default.
• W2968059887 cites W2909667183 @default.
• W2968059887 cites W3103489897 @default.
• W2968059887 doi "https://doi.org/10.3389/fnins.2019.00890" @default.
• W2968059887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6727854" @default.
• W2968059887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31555074" @default.
• W2968059887 hasPublicationYear "2019" @default.
• W2968059887 type Work @default.
• W2968059887 sameAs 2968059887 @default.
• W2968059887 citedByCount "11" @default.
• W2968059887 countsByYear W29680598872020 @default.
• W2968059887 countsByYear W29680598872021 @default.
• W2968059887 countsByYear W29680598872022 @default.
• W2968059887 countsByYear W29680598872023 @default.
• W2968059887 crossrefType "journal-article" @default.
• W2968059887 hasAuthorship W2968059887A5002285448 @default.
• W2968059887 hasAuthorship W2968059887A5022406055 @default.
• W2968059887 hasAuthorship W2968059887A5030749207 @default.
• W2968059887 hasAuthorship W2968059887A5031898190 @default.
• W2968059887 hasAuthorship W2968059887A5032635092 @default.
• W2968059887 hasAuthorship W2968059887A5036511331 @default.
• W2968059887 hasAuthorship W2968059887A5056784071 @default.
• W2968059887 hasAuthorship W2968059887A5056817341 @default.
• W2968059887 hasAuthorship W2968059887A5062525214 @default.
• W2968059887 hasAuthorship W2968059887A5063291869 @default.
• W2968059887 hasAuthorship W2968059887A5065654448 @default.
• W2968059887 hasAuthorship W2968059887A5084931025 @default.
• W2968059887 hasAuthorship W2968059887A5090447356 @default.
• W2968059887 hasBestOaLocation W29680598871 @default.
• W2968059887 hasConcept C104317684 @default.
• W2968059887 hasConcept C107459253 @default.
• W2968059887 hasConcept C136229726 @default.
• W2968059887 hasConcept C145103041 @default.
• W2968059887 hasConcept C168451700 @default.
• W2968059887 hasConcept C169760540 @default.
• W2968059887 hasConcept C171056886 @default.
• W2968059887 hasConcept C2908765479 @default.
• W2968059887 hasConcept C41008148 @default.
• W2968059887 hasConcept C55493867 @default.
• W2968059887 hasConcept C71924100 @default.
• W2968059887 hasConcept C86803240 @default.
• W2968059887 hasConcept C89429830 @default.
• W2968059887 hasConcept C95444343 @default.
• W2968059887 hasConceptScore W2968059887C104317684 @default.

• next