Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968115457> ?p ?o ?g. }
- W2968115457 endingPage "57" @default.
- W2968115457 startingPage "53" @default.
- W2968115457 abstract "BackgroundInhaled corticosteroids (ICS) decrease airway inflammation and airway hyperresponsiveness (AHR). Previous studies have generally investigated the effect of ICS on methacholine-induced AHR following weeks or months of medium to high dose treatment.PurposeThe short-term effects of once-daily fluticasone furoate (FF) 100 mcg on methacholine-induced AHR and airway inflammation were examined over the course of one week.MethodsEleven mild asthmatics completed this randomized, double-blind crossover study. Once-daily FF (100 mcg) and identical appearing placebo Ellipta® inhalers were given for 7 days with a 2-week washout. Methacholine challenges were performed before and 24 h after the first, third and seventh doses. Fractional exhaled nitric oxide (FeNO) was measured initially and at 7 days.ResultsFF significantly (p = 0.0009–0.0078) increased methacholine PD20 (provocative dose causing 20% fall in forced expiratory volume in 1 s) at all times. Doubling dose shifts (95% CI) were 1.23 (0.60–1.86), 1.17 (0.68–1.67) and 1.44 (0.93–1.94) after the first, third and seventh dose respectively. FeNO (geometric mean, 95% CI) decreased significantly (p = 0.0049) following FF treatment from 37.9 ppb (23.7–60.5) initially to 22.9 ppb (14.8–35.5) at 7 days. Placebo did not affect methacholine PD20 or FeNO.ConclusionSingle-dose FF 100 mcg decreased methacholine AHR at 24 h without significant further improvement with continued daily use over 7 days. The inhibition in AHR after one week of daily dosing coincided with a significant decrease in FeNO at 7 days. Contrary to past assumptions, the ICS FF appears to rapidly reduce AHR to methacholine." @default.
- W2968115457 created "2019-08-22" @default.
- W2968115457 creator A5000415992 @default.
- W2968115457 creator A5016241585 @default.
- W2968115457 creator A5024843726 @default.
- W2968115457 creator A5068367175 @default.
- W2968115457 date "2019-09-01" @default.
- W2968115457 modified "2023-10-16" @default.
- W2968115457 title "Short-term effect of once-daily fluticasone furoate on methacholine-induced bronchoconstriction in mild asthmatics" @default.
- W2968115457 cites W1487606138 @default.
- W2968115457 cites W1963853409 @default.
- W2968115457 cites W1991316167 @default.
- W2968115457 cites W2019496644 @default.
- W2968115457 cites W2027488557 @default.
- W2968115457 cites W2029021195 @default.
- W2968115457 cites W2046862221 @default.
- W2968115457 cites W2049853440 @default.
- W2968115457 cites W2053880789 @default.
- W2968115457 cites W2077305628 @default.
- W2968115457 cites W2078416455 @default.
- W2968115457 cites W2086928931 @default.
- W2968115457 cites W2096443988 @default.
- W2968115457 cites W2099449365 @default.
- W2968115457 cites W2109548522 @default.
- W2968115457 cites W2125078269 @default.
- W2968115457 cites W2125252801 @default.
- W2968115457 cites W2140678268 @default.
- W2968115457 cites W2143096094 @default.
- W2968115457 cites W2143306682 @default.
- W2968115457 cites W2151520766 @default.
- W2968115457 cites W2162303606 @default.
- W2968115457 cites W2552094662 @default.
- W2968115457 cites W2611567798 @default.
- W2968115457 cites W2767449778 @default.
- W2968115457 cites W2801835076 @default.
- W2968115457 cites W2883942090 @default.
- W2968115457 cites W4211006694 @default.
- W2968115457 cites W4211217423 @default.
- W2968115457 doi "https://doi.org/10.1016/j.rmed.2019.08.007" @default.
- W2968115457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31434037" @default.
- W2968115457 hasPublicationYear "2019" @default.
- W2968115457 type Work @default.
- W2968115457 sameAs 2968115457 @default.
- W2968115457 citedByCount "3" @default.
- W2968115457 countsByYear W29681154572020 @default.
- W2968115457 countsByYear W29681154572021 @default.
- W2968115457 crossrefType "journal-article" @default.
- W2968115457 hasAuthorship W2968115457A5000415992 @default.
- W2968115457 hasAuthorship W2968115457A5016241585 @default.
- W2968115457 hasAuthorship W2968115457A5024843726 @default.
- W2968115457 hasAuthorship W2968115457A5068367175 @default.
- W2968115457 hasBestOaLocation W29681154571 @default.
- W2968115457 hasConcept C105922876 @default.
- W2968115457 hasConcept C126322002 @default.
- W2968115457 hasConcept C142724271 @default.
- W2968115457 hasConcept C151032500 @default.
- W2968115457 hasConcept C204787440 @default.
- W2968115457 hasConcept C27081682 @default.
- W2968115457 hasConcept C2776042228 @default.
- W2968115457 hasConcept C2776178081 @default.
- W2968115457 hasConcept C2776954882 @default.
- W2968115457 hasConcept C2777714996 @default.
- W2968115457 hasConcept C2779028295 @default.
- W2968115457 hasConcept C2780769369 @default.
- W2968115457 hasConcept C2781142857 @default.
- W2968115457 hasConcept C2781212218 @default.
- W2968115457 hasConcept C2781260171 @default.
- W2968115457 hasConcept C42219234 @default.
- W2968115457 hasConcept C71924100 @default.
- W2968115457 hasConcept C87813604 @default.
- W2968115457 hasConceptScore W2968115457C105922876 @default.
- W2968115457 hasConceptScore W2968115457C126322002 @default.
- W2968115457 hasConceptScore W2968115457C142724271 @default.
- W2968115457 hasConceptScore W2968115457C151032500 @default.
- W2968115457 hasConceptScore W2968115457C204787440 @default.
- W2968115457 hasConceptScore W2968115457C27081682 @default.
- W2968115457 hasConceptScore W2968115457C2776042228 @default.
- W2968115457 hasConceptScore W2968115457C2776178081 @default.
- W2968115457 hasConceptScore W2968115457C2776954882 @default.
- W2968115457 hasConceptScore W2968115457C2777714996 @default.
- W2968115457 hasConceptScore W2968115457C2779028295 @default.
- W2968115457 hasConceptScore W2968115457C2780769369 @default.
- W2968115457 hasConceptScore W2968115457C2781142857 @default.
- W2968115457 hasConceptScore W2968115457C2781212218 @default.
- W2968115457 hasConceptScore W2968115457C2781260171 @default.
- W2968115457 hasConceptScore W2968115457C42219234 @default.
- W2968115457 hasConceptScore W2968115457C71924100 @default.
- W2968115457 hasConceptScore W2968115457C87813604 @default.
- W2968115457 hasLocation W29681154571 @default.
- W2968115457 hasLocation W29681154572 @default.
- W2968115457 hasOpenAccess W2968115457 @default.
- W2968115457 hasPrimaryLocation W29681154571 @default.
- W2968115457 hasRelatedWork W2011826394 @default.
- W2968115457 hasRelatedWork W2022965683 @default.
- W2968115457 hasRelatedWork W2036032198 @default.
- W2968115457 hasRelatedWork W2058690319 @default.
- W2968115457 hasRelatedWork W2066269381 @default.
- W2968115457 hasRelatedWork W2066635153 @default.