Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968127223> ?p ?o ?g. }
- W2968127223 endingPage "876" @default.
- W2968127223 startingPage "876" @default.
- W2968127223 abstract "Colonization of the gut in early life can be altered through multiple environmental factors. The present study aimed to investigate the effects of 2'-fucosyllactose (2'-FL), a mixture of short-chain galactooligosaccharides/long-chain fructooligosaccharides (scGOS/lcFOS) 9:1 and their combination (scGOS/lcFOS/2'-FL) on dysbiosis induced during rotavirus (RV) diarrhea in neonatal rats, elucidating crosstalk between bacteria and the immune system. The dietary interventions were administered daily by oral gavage at days 2-8 of life in neonatal Lewis rats. On day 5, RV SA11 was intragastrically delivered to induce infection and diarrhea assessment, microbiota composition, and gene expression of Toll-like receptors (TLRs) in the small intestine were studied. All dietary interventions showed reduction in clinical variables of RV-induced diarrhea. RV infection increased TLR2 expression, whereas 2'-FL boosted TLR5 and TLR7 expressions and scGOS/lcFOS increased that of TLR9. RV-infected rats displayed an intestinal dysbiosis that was effectively prevented by the dietary interventions, and consequently, their microbiota was more similar to microbiota of the noninfected groups. The preventive effect of 2'-FL, scGOS/lcFOS, and their combination on dysbiosis associated to RV diarrhea in rats could be due to changes in the crosstalk between gut microbiota and the innate immune system." @default.
- W2968127223 created "2019-08-22" @default.
- W2968127223 creator A5003508862 @default.
- W2968127223 creator A5017280079 @default.
- W2968127223 creator A5023267835 @default.
- W2968127223 creator A5025274981 @default.
- W2968127223 creator A5032799892 @default.
- W2968127223 creator A5046447559 @default.
- W2968127223 creator A5051105540 @default.
- W2968127223 creator A5059731389 @default.
- W2968127223 creator A5066849637 @default.
- W2968127223 creator A5067535218 @default.
- W2968127223 creator A5071939472 @default.
- W2968127223 creator A5075745009 @default.
- W2968127223 date "2019-08-11" @default.
- W2968127223 modified "2023-10-18" @default.
- W2968127223 title "Oligosaccharides Modulate Rotavirus-Associated Dysbiosis and TLR Gene Expression in Neonatal Rats" @default.
- W2968127223 cites W1427125429 @default.
- W2968127223 cites W1574364696 @default.
- W2968127223 cites W1647551795 @default.
- W2968127223 cites W1859708123 @default.
- W2968127223 cites W1938329966 @default.
- W2968127223 cites W1969272412 @default.
- W2968127223 cites W1971564068 @default.
- W2968127223 cites W1977328678 @default.
- W2968127223 cites W1986499171 @default.
- W2968127223 cites W1989162493 @default.
- W2968127223 cites W2001436735 @default.
- W2968127223 cites W2009954425 @default.
- W2968127223 cites W2026528407 @default.
- W2968127223 cites W2033023829 @default.
- W2968127223 cites W2034987674 @default.
- W2968127223 cites W2036897871 @default.
- W2968127223 cites W2040738201 @default.
- W2968127223 cites W2047215263 @default.
- W2968127223 cites W2047915395 @default.
- W2968127223 cites W2057766440 @default.
- W2968127223 cites W2059496003 @default.
- W2968127223 cites W2059804687 @default.
- W2968127223 cites W2060741641 @default.
- W2968127223 cites W2068432192 @default.
- W2968127223 cites W2075612853 @default.
- W2968127223 cites W2081653606 @default.
- W2968127223 cites W2084656095 @default.
- W2968127223 cites W2090110425 @default.
- W2968127223 cites W2093829386 @default.
- W2968127223 cites W2096436144 @default.
- W2968127223 cites W2098855274 @default.
- W2968127223 cites W2099625831 @default.
- W2968127223 cites W2107277218 @default.
- W2968127223 cites W2110699250 @default.
- W2968127223 cites W2115701239 @default.
- W2968127223 cites W2124076113 @default.
- W2968127223 cites W2132322328 @default.
- W2968127223 cites W2144256579 @default.
- W2968127223 cites W2158409478 @default.
- W2968127223 cites W2160895962 @default.
- W2968127223 cites W2165561182 @default.
- W2968127223 cites W2167294690 @default.
- W2968127223 cites W2192080449 @default.
- W2968127223 cites W2200372542 @default.
- W2968127223 cites W2286603297 @default.
- W2968127223 cites W2297172193 @default.
- W2968127223 cites W2337372962 @default.
- W2968127223 cites W2344275145 @default.
- W2968127223 cites W2400270334 @default.
- W2968127223 cites W2401857311 @default.
- W2968127223 cites W2513190687 @default.
- W2968127223 cites W2523123812 @default.
- W2968127223 cites W2530574460 @default.
- W2968127223 cites W2546024328 @default.
- W2968127223 cites W2574079157 @default.
- W2968127223 cites W2576197352 @default.
- W2968127223 cites W2581574598 @default.
- W2968127223 cites W2586587911 @default.
- W2968127223 cites W2593928562 @default.
- W2968127223 cites W2603546255 @default.
- W2968127223 cites W2606521949 @default.
- W2968127223 cites W2613265232 @default.
- W2968127223 cites W2692466304 @default.
- W2968127223 cites W2741510253 @default.
- W2968127223 cites W2754762941 @default.
- W2968127223 cites W2762778901 @default.
- W2968127223 cites W2766236028 @default.
- W2968127223 cites W2772025401 @default.
- W2968127223 cites W2792983506 @default.
- W2968127223 cites W2801985960 @default.
- W2968127223 cites W2883610225 @default.
- W2968127223 cites W2886376263 @default.
- W2968127223 cites W2887302674 @default.
- W2968127223 cites W2895362984 @default.
- W2968127223 cites W2900818172 @default.
- W2968127223 cites W2901793942 @default.
- W2968127223 cites W2909751170 @default.
- W2968127223 cites W769530797 @default.
- W2968127223 doi "https://doi.org/10.3390/cells8080876" @default.
- W2968127223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721706" @default.
- W2968127223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31405262" @default.