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- W2968150319 abstract "We unveiled an underside binding site on smoothened receptor (SMO) by a colocalization strategy using two structurally complementary photoaffinity probes derived from a known ligand Allo-1. Docking study and structural dissection identified key interactions within the site, including hydrogen bonding, π-π interactions, and hydrophobic interactions between Allo-1 and its contacting residues. Taken together, our results reveal the molecular base of Allo-1 binding and provide a basis for the design of new-generation ligands to overcome drug resistance." @default.
- W2968150319 created "2019-08-22" @default.
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- W2968150319 date "2019-08-13" @default.
- W2968150319 modified "2023-10-15" @default.
- W2968150319 title "Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor" @default.
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- W2968150319 doi "https://doi.org/10.1021/acs.jmedchem.9b00283" @default.
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