FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968165963> ?p ?o ?g. }

• W2968165963 abstract "Abstract Background Lung adenocarcinoma (LUAD) is one of the leading contributors to cancer‐related deaths worldwide. The objective of the current study is to identify a multidimensional transcriptome prognostic signature by combining protein‐coding gene (PCG) with long non‐coding RNA (lncRNA) for patients with LUAD. Methods We obtained LUAD PCG and lncRNA expression profile data from three datasets in the Gene Expression Omnibus database and conducted survival analyzes for these individuals. Results We established a predictive model comprising the three PCGs (NHLRC2, PLIN5, GNAI3), and one lncRNA ( AC087521.1 ). This model segregated patients with LUAD into low‐ and high‐risk groups based on significant differences in survival in the training dataset (GSE31210, n = 226, log‐rank test P < .001). Risk stratification of the model was subsequently validated in other two test datasets (GSE37745, n = 106, log‐rank test P < .001; GSE30219, n = 85, log‐rank test P = .006). Time‐dependent receiver operating characteristic (timeROC) curve analysis demonstrated that the model correlated strongly with disease progression and outperformed pathological stage in terms of prognostic ability. Cox proportional hazards regression analysis revealed that the signature could serve as an independent predictor of clinical outcomes in patients with LUAD. Conclusions We describe a novel multidimensional transcriptome signature that can predict survival probabilities in patients with LUAD." @default.
• W2968165963 created "2019-08-22" @default.
• W2968165963 creator A5016814369 @default.
• W2968165963 creator A5031597080 @default.
• W2968165963 creator A5044301848 @default.
• W2968165963 creator A5047620686 @default.
• W2968165963 creator A5048101049 @default.
• W2968165963 date "2019-08-11" @default.
• W2968165963 modified "2023-10-16" @default.
• W2968165963 title "Identification of a multidimensional transcriptome prognostic signature for lung adenocarcinoma" @default.
• W2968165963 cites W1840017206 @default.
• W2968165963 cites W1946086926 @default.
• W2968165963 cites W1953677527 @default.
• W2968165963 cites W1978967539 @default.
• W2968165963 cites W2012858030 @default.
• W2968165963 cites W2035618305 @default.
• W2968165963 cites W2059191987 @default.
• W2968165963 cites W2062641317 @default.
• W2968165963 cites W2125548623 @default.
• W2968165963 cites W2129375421 @default.
• W2968165963 cites W2132444060 @default.
• W2968165963 cites W2142653602 @default.
• W2968165963 cites W2167663414 @default.
• W2968165963 cites W2251438188 @default.
• W2968165963 cites W2309904837 @default.
• W2968165963 cites W2534565779 @default.
• W2968165963 cites W2558648052 @default.
• W2968165963 cites W2580612343 @default.
• W2968165963 cites W2801478434 @default.
• W2968165963 cites W2802779315 @default.
• W2968165963 cites W2883463239 @default.
• W2968165963 cites W2912865333 @default.
• W2968165963 doi "https://doi.org/10.1002/jcla.22990" @default.
• W2968165963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6868416" @default.
• W2968165963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31402485" @default.
• W2968165963 hasPublicationYear "2019" @default.
• W2968165963 type Work @default.
• W2968165963 sameAs 2968165963 @default.
• W2968165963 citedByCount "9" @default.
• W2968165963 countsByYear W29681659632021 @default.
• W2968165963 countsByYear W29681659632022 @default.
• W2968165963 countsByYear W29681659632023 @default.
• W2968165963 crossrefType "journal-article" @default.
• W2968165963 hasAuthorship W2968165963A5016814369 @default.
• W2968165963 hasAuthorship W2968165963A5031597080 @default.
• W2968165963 hasAuthorship W2968165963A5044301848 @default.
• W2968165963 hasAuthorship W2968165963A5047620686 @default.
• W2968165963 hasAuthorship W2968165963A5048101049 @default.
• W2968165963 hasBestOaLocation W29681659631 @default.
• W2968165963 hasConcept C104317684 @default.
• W2968165963 hasConcept C10515644 @default.
• W2968165963 hasConcept C105795698 @default.
• W2968165963 hasConcept C121608353 @default.
• W2968165963 hasConcept C126322002 @default.
• W2968165963 hasConcept C143998085 @default.
• W2968165963 hasConcept C150194340 @default.
• W2968165963 hasConcept C162317418 @default.
• W2968165963 hasConcept C179518139 @default.
• W2968165963 hasConcept C207886595 @default.
• W2968165963 hasConcept C2524010 @default.
• W2968165963 hasConcept C2779696439 @default.
• W2968165963 hasConcept C2781182431 @default.
• W2968165963 hasConcept C33923547 @default.
• W2968165963 hasConcept C41008148 @default.
• W2968165963 hasConcept C50382708 @default.
• W2968165963 hasConcept C54355233 @default.
• W2968165963 hasConcept C58471807 @default.
• W2968165963 hasConcept C60644358 @default.
• W2968165963 hasConcept C66339696 @default.
• W2968165963 hasConcept C70721500 @default.
• W2968165963 hasConcept C71924100 @default.
• W2968165963 hasConcept C86803240 @default.
• W2968165963 hasConceptScore W2968165963C104317684 @default.
• W2968165963 hasConceptScore W2968165963C10515644 @default.
• W2968165963 hasConceptScore W2968165963C105795698 @default.
• W2968165963 hasConceptScore W2968165963C121608353 @default.
• W2968165963 hasConceptScore W2968165963C126322002 @default.
• W2968165963 hasConceptScore W2968165963C143998085 @default.
• W2968165963 hasConceptScore W2968165963C150194340 @default.
• W2968165963 hasConceptScore W2968165963C162317418 @default.
• W2968165963 hasConceptScore W2968165963C179518139 @default.
• W2968165963 hasConceptScore W2968165963C207886595 @default.
• W2968165963 hasConceptScore W2968165963C2524010 @default.
• W2968165963 hasConceptScore W2968165963C2779696439 @default.
• W2968165963 hasConceptScore W2968165963C2781182431 @default.
• W2968165963 hasConceptScore W2968165963C33923547 @default.
• W2968165963 hasConceptScore W2968165963C41008148 @default.
• W2968165963 hasConceptScore W2968165963C50382708 @default.
• W2968165963 hasConceptScore W2968165963C54355233 @default.
• W2968165963 hasConceptScore W2968165963C58471807 @default.
• W2968165963 hasConceptScore W2968165963C60644358 @default.
• W2968165963 hasConceptScore W2968165963C66339696 @default.
• W2968165963 hasConceptScore W2968165963C70721500 @default.
• W2968165963 hasConceptScore W2968165963C71924100 @default.
• W2968165963 hasConceptScore W2968165963C86803240 @default.
• W2968165963 hasIssue "9" @default.
• W2968165963 hasLocation W29681659631 @default.
• W2968165963 hasLocation W29681659632 @default.
• W2968165963 hasLocation W29681659633 @default.
• W2968165963 hasOpenAccess W2968165963 @default.

• next