FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968180545> ?p ?o ?g. }

• W2968180545 endingPage "172593" @default.
• W2968180545 startingPage "172593" @default.
• W2968180545 abstract "We focused on the cyclophosphamide-induced hemorrhagic cystitis (100 mg/kg/day intraperitoneally throughout three days) as a particular NO-system disturbance, and therapy possibilities. We demonstrated that it may be attenuated by subsequent administration of the NOS substrate L-arginine (100 mg/kg/day intraperitoneally), aggravated by NOS-blocker L-NAME (5 mg/kg/day intraperitoneally), all influenced by the stable gastric pentadecapeptide BPC 157 (10 μg/kg/day, 10 ng/kg/day, intraperitoneally or perorally, in drinking water). Regularly, cyclophosphamide dose- and time-dependently induced severe hemorrhagic cystitis lesions, gross lesions, and corresponding urothelial necrosis, vesical edema, erosion, hemorrhage, inflammation, and ulceration, microscopically. The bladder wet weight dramatically increased. Functionally, already after first cyclophosphamide administration, there is an increased leak point pressure. Until the second cyclophosphamide administration, L-arginine consistently attenuated regular cyclophosphamide-induced severe hemorrhagic cystitis lesions, grossly and microscopically, but not functionally. L-NAME aggravated these lesions and eradicated beneficial effect of L-arginine when combined. BPC 157 administration after cyclophosphamide, given in either dose or in either regimen markedly attenuated all cyclophosphamide lesions, grossly, microscopically. The increase of the bladder wet weight was consistently attenuated. Functionally, increased leak point pressure was reversed to the values noted in normal rats. The similar findings were noted in rats that received BPC 157 together with L-NAME or L-arginine, given alone or combined. Thus, the lesions are NO-related based on the administration of L-NAME as well as administration of L-arginine, and their mutual interaction, and counteraction by BPC 157 application. Likewise, we reveal new therapeutic possibilities, emphasizing stable gastric pentadecapeptide BPC 157 and L-arginine, versus L-NAME in rats underwent cyclophosphamide-induced cystitis." @default.
• W2968180545 created "2019-08-22" @default.
• W2968180545 creator A5003545175 @default.
• W2968180545 creator A5006573657 @default.
• W2968180545 creator A5013451775 @default.
• W2968180545 creator A5013887070 @default.
• W2968180545 creator A5017342414 @default.
• W2968180545 creator A5021800176 @default.
• W2968180545 creator A5040384554 @default.
• W2968180545 creator A5040825323 @default.
• W2968180545 creator A5049495381 @default.
• W2968180545 creator A5050435159 @default.
• W2968180545 creator A5050520186 @default.
• W2968180545 creator A5051423361 @default.
• W2968180545 creator A5075557362 @default.
• W2968180545 creator A5079749727 @default.
• W2968180545 date "2019-10-01" @default.
• W2968180545 modified "2023-09-26" @default.
• W2968180545 title "Therapy of the rat hemorrhagic cystitis induced by cyclophosphamide. Stable gastric pentadecapeptide BPC 157, L-arginine, L-NAME" @default.
• W2968180545 cites W1488353016 @default.
• W2968180545 cites W1971122873 @default.
• W2968180545 cites W1976365291 @default.
• W2968180545 cites W1984510719 @default.
• W2968180545 cites W1985046431 @default.
• W2968180545 cites W1987409883 @default.
• W2968180545 cites W2004582144 @default.
• W2968180545 cites W2014754796 @default.
• W2968180545 cites W2021530697 @default.
• W2968180545 cites W2026995057 @default.
• W2968180545 cites W2034300124 @default.
• W2968180545 cites W2048474932 @default.
• W2968180545 cites W2076895464 @default.
• W2968180545 cites W2081463073 @default.
• W2968180545 cites W2113662018 @default.
• W2968180545 cites W2117094497 @default.
• W2968180545 cites W2117669151 @default.
• W2968180545 cites W2121358430 @default.
• W2968180545 cites W2138025841 @default.
• W2968180545 cites W2138665941 @default.
• W2968180545 cites W2140890175 @default.
• W2968180545 cites W2146729131 @default.
• W2968180545 cites W2158551725 @default.
• W2968180545 cites W2161579722 @default.
• W2968180545 cites W2165661552 @default.
• W2968180545 cites W2169386285 @default.
• W2968180545 cites W2232708276 @default.
• W2968180545 cites W2258353357 @default.
• W2968180545 cites W2269315630 @default.
• W2968180545 cites W2286079923 @default.
• W2968180545 cites W2347056727 @default.
• W2968180545 cites W2419461484 @default.
• W2968180545 cites W2520799412 @default.
• W2968180545 cites W2547000105 @default.
• W2968180545 cites W2556959132 @default.
• W2968180545 cites W2590008560 @default.
• W2968180545 cites W2592642890 @default.
• W2968180545 cites W2616514904 @default.
• W2968180545 cites W2745088377 @default.
• W2968180545 cites W2780820000 @default.
• W2968180545 cites W2793719339 @default.
• W2968180545 cites W2808512344 @default.
• W2968180545 cites W2810235423 @default.
• W2968180545 cites W2811536948 @default.
• W2968180545 cites W2885357008 @default.
• W2968180545 cites W2905765253 @default.
• W2968180545 cites W2907173452 @default.
• W2968180545 cites W2913146335 @default.
• W2968180545 cites W2924232478 @default.
• W2968180545 cites W4206348510 @default.
• W2968180545 doi "https://doi.org/10.1016/j.ejphar.2019.172593" @default.
• W2968180545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31401154" @default.
• W2968180545 hasPublicationYear "2019" @default.
• W2968180545 type Work @default.
• W2968180545 sameAs 2968180545 @default.
• W2968180545 citedByCount "34" @default.
• W2968180545 countsByYear W29681805452020 @default.
• W2968180545 countsByYear W29681805452021 @default.
• W2968180545 countsByYear W29681805452022 @default.
• W2968180545 countsByYear W29681805452023 @default.
• W2968180545 crossrefType "journal-article" @default.
• W2968180545 hasAuthorship W2968180545A5003545175 @default.
• W2968180545 hasAuthorship W2968180545A5006573657 @default.
• W2968180545 hasAuthorship W2968180545A5013451775 @default.
• W2968180545 hasAuthorship W2968180545A5013887070 @default.
• W2968180545 hasAuthorship W2968180545A5017342414 @default.
• W2968180545 hasAuthorship W2968180545A5021800176 @default.
• W2968180545 hasAuthorship W2968180545A5040384554 @default.
• W2968180545 hasAuthorship W2968180545A5040825323 @default.
• W2968180545 hasAuthorship W2968180545A5049495381 @default.
• W2968180545 hasAuthorship W2968180545A5050435159 @default.
• W2968180545 hasAuthorship W2968180545A5050520186 @default.
• W2968180545 hasAuthorship W2968180545A5051423361 @default.
• W2968180545 hasAuthorship W2968180545A5075557362 @default.
• W2968180545 hasAuthorship W2968180545A5079749727 @default.
• W2968180545 hasConcept C126322002 @default.
• W2968180545 hasConcept C134018914 @default.
• W2968180545 hasConcept C185592680 @default.
• W2968180545 hasConcept C2776694085 @default.

• next