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• W2968185410 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disease that ranks as the fourth most common cause of death in developed countries. In our study, genes differentially expressed between AD and healthy individuals were identified and used to construct protein-protein interaction (PPI) networks. The AD-related PPI network was used to identify functional modules, and enrichment analysis showed that they were significantly involved in Alzheimer's disease, apoptosis, and related pathways. We predicted non-coding RNAs and transcription factors that may regulate the functional modules. The expression of hub genes and transcription factors was validated in an independent data set. The results in this study provide several candidates for further research on mechanisms of AD pathogenesis." @default.
• W2968185410 created "2019-08-22" @default.
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• W2968185410 date "2019-08-16" @default.
• W2968185410 modified "2023-09-24" @default.
• W2968185410 title "Analysis of transcription factor- and ncRNA-mediated potential pathogenic gene modules in Alzheimer’s disease" @default.
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• W2968185410 doi "https://doi.org/10.18632/aging.102169" @default.
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