Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968221486> ?p ?o ?g. }
- W2968221486 endingPage "110536" @default.
- W2968221486 startingPage "110536" @default.
- W2968221486 abstract "Clinical studies have revealed that the risk of Alzheimer's disease (AD) in men is increased by age-related androgen depletion. The level of β-amyloid (Aβ) is elevated in the brains of AD patients, and Aβ is believed to play a critical role in the pathology of AD. Some studies have indicated that androgens affect AD risk by regulating the metabolism of Aβ by an unclear mechanism. In this study, we investigated the role of the extracellular matrix metalloproteinase inducer (CD147) in this action. Initially, we demonstrated that androgens positively regulate the expression of CD147 in adult male rats and SH-SY5Y cells. Furthermore, this regulation may involve androgen receptor (AR). Additionally, interference of CD147 expression decreased the clearance of Aβ in culture medium and reduced cell viability. It also affected the morphology of the cells and the expression of apoptosis-related proteins. Finally, we found that interference of CD147 expression blocked the dihydrotestosterone (DHT)-induced reduction in Aβ and the protection of cells. DHT regulates MMP-2's expression through CD147. Together, these results imply that androgen regulation of Aβ and cell protection may be affected by interfering with the expression of CD147." @default.
- W2968221486 created "2019-08-22" @default.
- W2968221486 creator A5017794176 @default.
- W2968221486 creator A5033541840 @default.
- W2968221486 creator A5050756000 @default.
- W2968221486 creator A5052925180 @default.
- W2968221486 creator A5063896719 @default.
- W2968221486 creator A5082065346 @default.
- W2968221486 date "2019-12-01" @default.
- W2968221486 modified "2023-10-16" @default.
- W2968221486 title "The role of extracellular matrix metalloproteinase inducer on the action of dihydrotestosterone against the cellular damage induced by Aβ42" @default.
- W2968221486 cites W1481451464 @default.
- W2968221486 cites W1566483010 @default.
- W2968221486 cites W1569248335 @default.
- W2968221486 cites W1583405069 @default.
- W2968221486 cites W1607075237 @default.
- W2968221486 cites W1616122655 @default.
- W2968221486 cites W1729585270 @default.
- W2968221486 cites W1806093456 @default.
- W2968221486 cites W1886431664 @default.
- W2968221486 cites W1952686113 @default.
- W2968221486 cites W1965049154 @default.
- W2968221486 cites W1973084192 @default.
- W2968221486 cites W1974695866 @default.
- W2968221486 cites W1975759742 @default.
- W2968221486 cites W1975907645 @default.
- W2968221486 cites W1982481915 @default.
- W2968221486 cites W1994344429 @default.
- W2968221486 cites W1997495297 @default.
- W2968221486 cites W2006794974 @default.
- W2968221486 cites W2011574003 @default.
- W2968221486 cites W2015708455 @default.
- W2968221486 cites W2022973538 @default.
- W2968221486 cites W2023205512 @default.
- W2968221486 cites W2024053743 @default.
- W2968221486 cites W2029623922 @default.
- W2968221486 cites W2038623734 @default.
- W2968221486 cites W2054384325 @default.
- W2968221486 cites W2070041795 @default.
- W2968221486 cites W2082154756 @default.
- W2968221486 cites W2087517855 @default.
- W2968221486 cites W2089825998 @default.
- W2968221486 cites W2092307951 @default.
- W2968221486 cites W2100245721 @default.
- W2968221486 cites W2101077392 @default.
- W2968221486 cites W2147919935 @default.
- W2968221486 cites W2150576468 @default.
- W2968221486 cites W2164067072 @default.
- W2968221486 cites W2209268688 @default.
- W2968221486 cites W2320378171 @default.
- W2968221486 cites W2590019068 @default.
- W2968221486 cites W851281458 @default.
- W2968221486 doi "https://doi.org/10.1016/j.mce.2019.110536" @default.
- W2968221486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31401349" @default.
- W2968221486 hasPublicationYear "2019" @default.
- W2968221486 type Work @default.
- W2968221486 sameAs 2968221486 @default.
- W2968221486 citedByCount "2" @default.
- W2968221486 countsByYear W29682214862022 @default.
- W2968221486 crossrefType "journal-article" @default.
- W2968221486 hasAuthorship W2968221486A5017794176 @default.
- W2968221486 hasAuthorship W2968221486A5033541840 @default.
- W2968221486 hasAuthorship W2968221486A5050756000 @default.
- W2968221486 hasAuthorship W2968221486A5052925180 @default.
- W2968221486 hasAuthorship W2968221486A5063896719 @default.
- W2968221486 hasAuthorship W2968221486A5082065346 @default.
- W2968221486 hasConcept C104317684 @default.
- W2968221486 hasConcept C109523444 @default.
- W2968221486 hasConcept C121608353 @default.
- W2968221486 hasConcept C126322002 @default.
- W2968221486 hasConcept C134018914 @default.
- W2968221486 hasConcept C185592680 @default.
- W2968221486 hasConcept C189165786 @default.
- W2968221486 hasConcept C190283241 @default.
- W2968221486 hasConcept C2225953 @default.
- W2968221486 hasConcept C2777911890 @default.
- W2968221486 hasConcept C2779881493 @default.
- W2968221486 hasConcept C2780192828 @default.
- W2968221486 hasConcept C28406088 @default.
- W2968221486 hasConcept C55493867 @default.
- W2968221486 hasConcept C61367390 @default.
- W2968221486 hasConcept C71315377 @default.
- W2968221486 hasConcept C71924100 @default.
- W2968221486 hasConcept C86803240 @default.
- W2968221486 hasConcept C95444343 @default.
- W2968221486 hasConceptScore W2968221486C104317684 @default.
- W2968221486 hasConceptScore W2968221486C109523444 @default.
- W2968221486 hasConceptScore W2968221486C121608353 @default.
- W2968221486 hasConceptScore W2968221486C126322002 @default.
- W2968221486 hasConceptScore W2968221486C134018914 @default.
- W2968221486 hasConceptScore W2968221486C185592680 @default.
- W2968221486 hasConceptScore W2968221486C189165786 @default.
- W2968221486 hasConceptScore W2968221486C190283241 @default.
- W2968221486 hasConceptScore W2968221486C2225953 @default.
- W2968221486 hasConceptScore W2968221486C2777911890 @default.
- W2968221486 hasConceptScore W2968221486C2779881493 @default.
- W2968221486 hasConceptScore W2968221486C2780192828 @default.
- W2968221486 hasConceptScore W2968221486C28406088 @default.