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• W2968221577 startingPage "3504" @default.
• W2968221577 abstract "The nutritional cost of activating B cell-mediated immunity is thought to be low in chickens. However, this assumption is incompletely characterized. Immunoglobulin knockout (Ig-KO) chickens lacking B cells and immunoglobulin may potentially be a robust model to investigate the nutritional cost of immunity. Specifically, comparing the growth of Ig-KO chickens to immunocompetent birds (WT) following activation of the immune system should indicate costs associated with B cell-mediated immunity. A total of 3 experiments were conducted to determine if (1) an antibody response to keyhole limpet hemocyanin (KLH), (2) an intra-abdominal injection with Salmonella enterica serovar Enteritidis (SE), or (3) an oral challenge of SE would affect body weight gain (BWG) in homozygous Ig-KO (KO) chickens and their immunocompetent counterparts. In Experiment 1, a significant genotype*vaccination status interaction was observed (P = 0.03) during the period from 0 to 6 D after initial vaccination in which KLH injection reduced BWG in WT birds, but not in KO birds. A genotype*vaccination status interaction was present (P = 0.002) from 0 to 7 D after the first booster in which KLH injection due to reduced BWG in KO birds, but not WT birds. In Experiment 2, both KO and immunocompetent birds lost body weight during the period from 0 to 2 D after the SE injection, with no significant differences due to genotype (P = 0.92). Experiment 3 demonstrated that KO birds gained less weight than immunocompetent birds, with a tendency for less weight gain after an initial challenge (P = 0.07) and significantly so after a secondary challenge (P = 0.03). The results from these experiments collectively demonstrate that B cell-mediated immunity can affect growth performance in chickens. Furthermore, these effects can either preserve or impair growth performance, likely via mechanisms related to the immune response rather than the discrete nutritional cost of B cell-mediated immunity." @default.
• W2968221577 created "2019-08-22" @default.
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• W2968221577 date "2019-09-01" @default.
• W2968221577 modified "2023-09-27" @default.
• W2968221577 title "The effects of vaccination with keyhole limpet hemocyanin or oral administration of Salmonella enterica serovar Enteritidis on the growth performance of immunoglobulin knockout chickens" @default.
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• W2968221577 doi "https://doi.org/10.3382/ps/pez172" @default.
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