FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968241016> ?p ?o ?g. }

• W2968241016 abstract "Mounting evidence indicates that the cerebral cortex is an important physiological system of emotional activity, and its dysfunction may be the main cause of stress. Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS), which initiates rapid signal transmission in the synapse before its reuptake into the surrounding glia, specifically astrocytes (ASTs). The astrocytic excitatory amino acid transporters 1 (EAAT1) and 2 (EAAT2) are the major transporters that take up synaptic glutamate to maintain optimal extracellular glutamic levels, thus preventing accumulation in the synaptic cleft and ensuing excitotoxicity. Growing evidence has shown that excitotoxicity is associated with depression. Therefore, we hypothesized that the underlying antidepressant-like mechanism of Xiaoyaosan (XYS), a Chinese herbal formula, may be related to the regulation of astrocytic EAATs. Therefore, we studied the antidepressant mechanism of XYS on the basis of EAAT dysfunction in ASTs. Eighty adult C57BL/6 J mice were randomly divided into 4 groups: a control group, a chronic unpredictable mild stress (CUMS) group, a Xiaoyaosan (XYS) treatment group and a fluoxetine hydrochloride (Flu) treatment group. Except for the control group, mice in the other groups all received chronic unpredictable mild stress for 21 days. Mice in the control and CUMS groups received gavage administration with 0.5 mL of normal saline (NS) for 21 days, and mice in the XYS and Flu treatment groups were administered dosages of 0.25 g/kg/d and 2.6 mg/kg/d by gavage. The effects of XYS on the depressive-like behavioral tests, including the open field test (OFT), forced swimming test (FST) and sucrose preference test (SPT), were examined. The glutamate (Glu) concentrations of the prefrontal cortex (PFC) were detected with colorimetry. The morphology of neurons in the PFC was observed by Nissl staining. The expression of glial fibrillary acidic protein (GFAP), NeuN, EAAT1 and EAAT2 proteins in the PFC of mice was detected by using Western blotting and immunohistochemistry. Quantitative real-time PCR (qPCR) was used to detect the expression of the GFAP, NeuN, EAAT1 and EAAT2 genes in the PFC of mice. The results of behavioral tests showed that CUMS-induced mice exhibited depressive-like behavior, which could be improved in some tests with XYS and Flu treatment. Immunohistochemistry and Western blot analysis showed that the protein levels of GFAP, NeuN, EAAT1 and EAAT2 in the PFC of CUMS mice were significantly lower than those in the control group, and these changes could be reversed by XYS and Flu. The results of qPCR analysis showed that the expression of GFAP, NeuN, EAAT1 and EAAT2 mRNAs in the PFC of CUMS mice was not significantly changed, with the exception of EAAT2, compared with that of the control group, while the expression of the above mRNAs was significantly higher in the XYS and Flu groups than that in the CUMS group. XYS may exert antidepressant-like effects by improving the functions of AST and EAATs and attenuating glutamate-induced neuronal damage in the frontal cortex." @default.
• W2968241016 created "2019-08-22" @default.
• W2968241016 creator A5001612078 @default.
• W2968241016 creator A5025401873 @default.
• W2968241016 creator A5036550978 @default.
• W2968241016 creator A5047164245 @default.
• W2968241016 creator A5060582592 @default.
• W2968241016 creator A5063119415 @default.
• W2968241016 creator A5069153812 @default.
• W2968241016 creator A5086792441 @default.
• W2968241016 creator A5090590010 @default.
• W2968241016 date "2019-08-14" @default.
• W2968241016 modified "2023-10-17" @default.
• W2968241016 title "Xiaoyaosan exerts antidepressant-like effects by regulating the functions of astrocytes and EAATs in the prefrontal cortex of mice" @default.
• W2968241016 cites W1727198338 @default.
• W2968241016 cites W1914381346 @default.
• W2968241016 cites W1963700716 @default.
• W2968241016 cites W1965556606 @default.
• W2968241016 cites W1971043748 @default.
• W2968241016 cites W1988766176 @default.
• W2968241016 cites W1990428243 @default.
• W2968241016 cites W2003982930 @default.
• W2968241016 cites W2004331086 @default.
• W2968241016 cites W2006218562 @default.
• W2968241016 cites W2010291328 @default.
• W2968241016 cites W2030260775 @default.
• W2968241016 cites W2031297664 @default.
• W2968241016 cites W2043713804 @default.
• W2968241016 cites W2044435294 @default.
• W2968241016 cites W2046599839 @default.
• W2968241016 cites W2048371307 @default.
• W2968241016 cites W2050887779 @default.
• W2968241016 cites W2050984501 @default.
• W2968241016 cites W2054197740 @default.
• W2968241016 cites W2058441239 @default.
• W2968241016 cites W2063235053 @default.
• W2968241016 cites W2070612991 @default.
• W2968241016 cites W2077980163 @default.
• W2968241016 cites W2086761335 @default.
• W2968241016 cites W2087776846 @default.
• W2968241016 cites W2142541067 @default.
• W2968241016 cites W2150002111 @default.
• W2968241016 cites W2150224475 @default.
• W2968241016 cites W2150916203 @default.
• W2968241016 cites W2158971252 @default.
• W2968241016 cites W2164479329 @default.
• W2968241016 cites W2192665460 @default.
• W2968241016 cites W2404740822 @default.
• W2968241016 cites W2410872715 @default.
• W2968241016 cites W2572281205 @default.
• W2968241016 cites W2592607714 @default.
• W2968241016 cites W2597123585 @default.
• W2968241016 cites W2666299810 @default.
• W2968241016 cites W2736763668 @default.
• W2968241016 cites W2790367203 @default.
• W2968241016 cites W2795471842 @default.
• W2968241016 cites W2799952127 @default.
• W2968241016 cites W2893589341 @default.
• W2968241016 cites W2910257112 @default.
• W2968241016 cites W2911431148 @default.
• W2968241016 cites W2913571576 @default.
• W2968241016 cites W2929395350 @default.
• W2968241016 cites W2944557009 @default.
• W2968241016 cites W2965597981 @default.
• W2968241016 cites W890895450 @default.
• W2968241016 doi "https://doi.org/10.1186/s12906-019-2613-6" @default.
• W2968241016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6694586" @default.
• W2968241016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31412844" @default.
• W2968241016 hasPublicationYear "2019" @default.
• W2968241016 type Work @default.
• W2968241016 sameAs 2968241016 @default.
• W2968241016 citedByCount "21" @default.
• W2968241016 countsByYear W29682410162020 @default.
• W2968241016 countsByYear W29682410162021 @default.
• W2968241016 countsByYear W29682410162022 @default.
• W2968241016 countsByYear W29682410162023 @default.
• W2968241016 crossrefType "journal-article" @default.
• W2968241016 hasAuthorship W2968241016A5001612078 @default.
• W2968241016 hasAuthorship W2968241016A5025401873 @default.
• W2968241016 hasAuthorship W2968241016A5036550978 @default.
• W2968241016 hasAuthorship W2968241016A5047164245 @default.
• W2968241016 hasAuthorship W2968241016A5060582592 @default.
• W2968241016 hasAuthorship W2968241016A5063119415 @default.
• W2968241016 hasAuthorship W2968241016A5069153812 @default.
• W2968241016 hasAuthorship W2968241016A5086792441 @default.
• W2968241016 hasAuthorship W2968241016A5090590010 @default.
• W2968241016 hasBestOaLocation W29682410161 @default.
• W2968241016 hasConcept C112592302 @default.
• W2968241016 hasConcept C126322002 @default.
• W2968241016 hasConcept C169760540 @default.
• W2968241016 hasConcept C169900460 @default.
• W2968241016 hasConcept C170493617 @default.
• W2968241016 hasConcept C17077164 @default.
• W2968241016 hasConcept C200170125 @default.
• W2968241016 hasConcept C2775864247 @default.
• W2968241016 hasConcept C2776134451 @default.
• W2968241016 hasConcept C2776219046 @default.
• W2968241016 hasConcept C2779085643 @default.
• W2968241016 hasConcept C2779177272 @default.
• W2968241016 hasConcept C2781012912 @default.

• next