FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968251151> ?p ?o ?g. }

• W2968251151 abstract "Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely administered to induce or speed labour. Due to lack of synthetized knowledge, we conducted a systematic review of maternal plasma levels of oxytocin during physiological childbirth, and in response to infusions of synthetic oxytocin, if reported in the included studies.An a priori protocol was designed and a systematic search was conducted in PubMed, CINAHL, and PsycINFO in October 2015. Search hits were screened on title and abstract after duplicates were removed (n = 4039), 69 articles were examined in full-text and 20 papers met inclusion criteria. As the articles differed in design and methodology used for analysis of oxytocin levels, a narrative synthesis was created and the material was categorised according to effects.Basal levels of oxytocin increased 3-4-fold during pregnancy. Pulses of oxytocin occurred with increasing frequency, duration, and amplitude, from late pregnancy through labour, reaching a maximum of 3 pulses/10 min towards the end of labour. There was a maximal 3- to 4-fold rise in oxytocin at birth. Oxytocin pulses also occurred in the third stage of labour associated with placental expulsion. Oxytocin peaks during labour did not correlate in time with individual uterine contractions, suggesting additional mechanisms in the control of contractions. Oxytocin levels were also raised in the cerebrospinal fluid during labour, indicating that oxytocin is released into the brain, as well as into the circulation. Oxytocin released into the brain induces beneficial adaptive effects during birth and postpartum. Oxytocin levels following infusion of synthetic oxytocin up to 10 mU/min were similar to oxytocin levels in physiological labour. Oxytocin levels doubled in response to doubling of the rate of infusion of synthetic oxytocin.Plasma oxytocin levels increase gradually during pregnancy, and during the first and second stages of labour, with increasing size and frequency of pulses of oxytocin. A large pulse of oxytocin occurs with birth. Oxytocin in the circulation stimulates uterine contractions and oxytocin released within the brain influences maternal physiology and behaviour during birth. Oxytocin given as an infusion does not cross into the mother's brain because of the blood brain barrier and does not influence brain function in the same way as oxytocin during normal labour does." @default.
• W2968251151 created "2019-08-22" @default.
• W2968251151 creator A5001072014 @default.
• W2968251151 creator A5004662893 @default.
• W2968251151 creator A5009155675 @default.
• W2968251151 creator A5021405296 @default.
• W2968251151 creator A5033981394 @default.
• W2968251151 creator A5036029440 @default.
• W2968251151 creator A5036480121 @default.
• W2968251151 creator A5040984533 @default.
• W2968251151 creator A5048522828 @default.
• W2968251151 creator A5061965891 @default.
• W2968251151 creator A5063900541 @default.
• W2968251151 creator A5064983054 @default.
• W2968251151 creator A5084860136 @default.
• W2968251151 creator A5089617931 @default.
• W2968251151 date "2019-08-09" @default.
• W2968251151 modified "2023-10-15" @default.
• W2968251151 title "Maternal plasma levels of oxytocin during physiological childbirth – a systematic review with implications for uterine contractions and central actions of oxytocin" @default.
• W2968251151 cites W1488549686 @default.
• W2968251151 cites W1564227599 @default.
• W2968251151 cites W1696611029 @default.
• W2968251151 cites W1815080139 @default.
• W2968251151 cites W1964255419 @default.
• W2968251151 cites W1967134567 @default.
• W2968251151 cites W1969253686 @default.
• W2968251151 cites W1983475538 @default.
• W2968251151 cites W2007472239 @default.
• W2968251151 cites W2012771984 @default.
• W2968251151 cites W2013381845 @default.
• W2968251151 cites W2015806134 @default.
• W2968251151 cites W2029348745 @default.
• W2968251151 cites W2035802189 @default.
• W2968251151 cites W2036136892 @default.
• W2968251151 cites W2038097841 @default.
• W2968251151 cites W2040492372 @default.
• W2968251151 cites W2048086784 @default.
• W2968251151 cites W2049175802 @default.
• W2968251151 cites W2060180675 @default.
• W2968251151 cites W2066556168 @default.
• W2968251151 cites W2068249072 @default.
• W2968251151 cites W2069537217 @default.
• W2968251151 cites W2070583268 @default.
• W2968251151 cites W2074111564 @default.
• W2968251151 cites W2076838044 @default.
• W2968251151 cites W2077352956 @default.
• W2968251151 cites W2080043750 @default.
• W2968251151 cites W2082339637 @default.
• W2968251151 cites W2086044671 @default.
• W2968251151 cites W2090689542 @default.
• W2968251151 cites W2103865454 @default.
• W2968251151 cites W2107197338 @default.
• W2968251151 cites W2111395948 @default.
• W2968251151 cites W2114374730 @default.
• W2968251151 cites W2116127545 @default.
• W2968251151 cites W2124422990 @default.
• W2968251151 cites W2134833483 @default.
• W2968251151 cites W2158037437 @default.
• W2968251151 cites W2159235123 @default.
• W2968251151 cites W2162954233 @default.
• W2968251151 cites W2165181648 @default.
• W2968251151 cites W2169830226 @default.
• W2968251151 cites W2239084372 @default.
• W2968251151 cites W2398296510 @default.
• W2968251151 cites W2400045157 @default.
• W2968251151 cites W2402318216 @default.
• W2968251151 cites W2403323326 @default.
• W2968251151 cites W2404874779 @default.
• W2968251151 cites W2407727284 @default.
• W2968251151 cites W2412018745 @default.
• W2968251151 cites W2498209759 @default.
• W2968251151 cites W2730204123 @default.
• W2968251151 cites W2790741447 @default.
• W2968251151 cites W2796101880 @default.
• W2968251151 cites W3007841854 @default.
• W2968251151 cites W4235489569 @default.
• W2968251151 cites W4242830047 @default.
• W2968251151 doi "https://doi.org/10.1186/s12884-019-2365-9" @default.
• W2968251151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6688382" @default.
• W2968251151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31399062" @default.
• W2968251151 hasPublicationYear "2019" @default.
• W2968251151 type Work @default.
• W2968251151 sameAs 2968251151 @default.
• W2968251151 citedByCount "121" @default.
• W2968251151 countsByYear W29682511512020 @default.
• W2968251151 countsByYear W29682511512021 @default.
• W2968251151 countsByYear W29682511512022 @default.
• W2968251151 countsByYear W29682511512023 @default.
• W2968251151 crossrefType "journal-article" @default.
• W2968251151 hasAuthorship W2968251151A5001072014 @default.
• W2968251151 hasAuthorship W2968251151A5004662893 @default.
• W2968251151 hasAuthorship W2968251151A5009155675 @default.
• W2968251151 hasAuthorship W2968251151A5021405296 @default.
• W2968251151 hasAuthorship W2968251151A5033981394 @default.
• W2968251151 hasAuthorship W2968251151A5036029440 @default.
• W2968251151 hasAuthorship W2968251151A5036480121 @default.
• W2968251151 hasAuthorship W2968251151A5040984533 @default.
• W2968251151 hasAuthorship W2968251151A5048522828 @default.
• W2968251151 hasAuthorship W2968251151A5061965891 @default.
• W2968251151 hasAuthorship W2968251151A5063900541 @default.

• next