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- W2968255719 endingPage "979.e20" @default.
- W2968255719 startingPage "964" @default.
- W2968255719 abstract "PIWI-interacting RNAs (piRNAs) guide transposon silencing in animals. The 22–30 nt piRNAs are processed in the cytoplasm from long non-coding RNAs that often lack RNA processing hallmarks of export-competent transcripts. By studying how these transcripts achieve nuclear export, we uncover an RNA export pathway specific for piRNA precursors in the Drosophila germline. This pathway requires Nxf3-Nxt1, a variant of the hetero-dimeric mRNA export receptor Nxf1-Nxt1. Nxf3 interacts with UAP56, a nuclear RNA helicase essential for mRNA export, and CG13741/Bootlegger, which recruits Nxf3-Nxt1 and UAP56 to heterochromatic piRNA source loci. Upon RNA cargo binding, Nxf3 achieves nuclear export via the exportin Crm1 and accumulates together with Bootlegger in peri-nuclear nuage, suggesting that after export, Nxf3-Bootlegger delivers precursor transcripts to the piRNA processing sites. These findings indicate that the piRNA pathway bypasses nuclear RNA surveillance systems to export unprocessed transcripts to the cytoplasm, a strategy also exploited by retroviruses." @default.
- W2968255719 created "2019-08-22" @default.
- W2968255719 creator A5005065924 @default.
- W2968255719 creator A5012895943 @default.
- W2968255719 creator A5014157354 @default.
- W2968255719 creator A5044585155 @default.
- W2968255719 creator A5067229157 @default.
- W2968255719 creator A5070218796 @default.
- W2968255719 creator A5076626519 @default.
- W2968255719 creator A5082852074 @default.
- W2968255719 date "2019-08-01" @default.
- W2968255719 modified "2023-10-16" @default.
- W2968255719 title "A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production" @default.
- W2968255719 cites W1596971406 @default.
- W2968255719 cites W1659482056 @default.
- W2968255719 cites W1918912400 @default.
- W2968255719 cites W192451759 @default.
- W2968255719 cites W1965978236 @default.
- W2968255719 cites W1967971115 @default.
- W2968255719 cites W1968817160 @default.
- W2968255719 cites W1974966784 @default.
- W2968255719 cites W1976342457 @default.
- W2968255719 cites W1976557090 @default.
- W2968255719 cites W1985567287 @default.
- W2968255719 cites W1986313893 @default.
- W2968255719 cites W1993445706 @default.
- W2968255719 cites W1996321460 @default.
- W2968255719 cites W1997570561 @default.
- W2968255719 cites W1998356880 @default.
- W2968255719 cites W2006062026 @default.
- W2968255719 cites W2014064723 @default.
- W2968255719 cites W2014620401 @default.
- W2968255719 cites W2016029650 @default.
- W2968255719 cites W2016153572 @default.
- W2968255719 cites W2018765039 @default.
- W2968255719 cites W2019860831 @default.
- W2968255719 cites W2026432964 @default.
- W2968255719 cites W2028995073 @default.
- W2968255719 cites W2030677655 @default.
- W2968255719 cites W2037534409 @default.
- W2968255719 cites W2042663939 @default.
- W2968255719 cites W2044369757 @default.
- W2968255719 cites W2045148753 @default.
- W2968255719 cites W2049314528 @default.
- W2968255719 cites W2049369269 @default.
- W2968255719 cites W2052390654 @default.
- W2968255719 cites W2053606962 @default.
- W2968255719 cites W2063394866 @default.
- W2968255719 cites W2065677302 @default.
- W2968255719 cites W2074324848 @default.
- W2968255719 cites W2077157705 @default.
- W2968255719 cites W2087934409 @default.
- W2968255719 cites W2097401587 @default.
- W2968255719 cites W2102619694 @default.
- W2968255719 cites W2103747393 @default.
- W2968255719 cites W2105202278 @default.
- W2968255719 cites W2110764940 @default.
- W2968255719 cites W2113377893 @default.
- W2968255719 cites W2114382620 @default.
- W2968255719 cites W2115559525 @default.
- W2968255719 cites W2118420574 @default.
- W2968255719 cites W2121348641 @default.
- W2968255719 cites W2124985265 @default.
- W2968255719 cites W2126958666 @default.
- W2968255719 cites W2126961090 @default.
- W2968255719 cites W2128016314 @default.
- W2968255719 cites W2132319942 @default.
- W2968255719 cites W2133336303 @default.
- W2968255719 cites W2135581618 @default.
- W2968255719 cites W2136148915 @default.
- W2968255719 cites W2138993899 @default.
- W2968255719 cites W2143718571 @default.
- W2968255719 cites W2149291473 @default.
- W2968255719 cites W2154572640 @default.
- W2968255719 cites W2155127403 @default.
- W2968255719 cites W2157378797 @default.
- W2968255719 cites W2164206207 @default.
- W2968255719 cites W2167279371 @default.
- W2968255719 cites W2168639701 @default.
- W2968255719 cites W2169456326 @default.
- W2968255719 cites W2181749183 @default.
- W2968255719 cites W2291938858 @default.
- W2968255719 cites W2325976840 @default.
- W2968255719 cites W2411724331 @default.
- W2968255719 cites W2498392978 @default.
- W2968255719 cites W2525209171 @default.
- W2968255719 cites W2560733134 @default.
- W2968255719 cites W2569123814 @default.
- W2968255719 cites W2592811885 @default.
- W2968255719 cites W2620721366 @default.
- W2968255719 cites W2748864067 @default.
- W2968255719 cites W2883812812 @default.
- W2968255719 cites W2891613138 @default.
- W2968255719 cites W2892519010 @default.
- W2968255719 cites W2897281125 @default.
- W2968255719 cites W2901318957 @default.
- W2968255719 cites W2903232440 @default.
- W2968255719 cites W2950942545 @default.