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• W2968261569 abstract "Transcatheter aortic valve replacement (TAVR) has become the standard treatment option for patients with symptomatic severe aortic stenosis (AS) with high surgical risk and a reasonable option for intermediate surgical risk as an alternative to surgical aortic valve replacement (SAVR). The role of TAVR in lower risk patients is less established but has been the focus of recent randomized controlled trials (RCTs). We performed a meta-analysis of RCTs to assess TAVR outcomes among low surgical risk patients. Systematic search of RCTs was done using PubMed, EMBASE, and Cochrane Library databases. Statistical analysis was performed with RevMan v5.3 software using a random effects model to report risk ratio (RR) with 95% confidence interval (CI). A total of three RCTs including 2698 patients (1375 TAVR and 1323 SAVR) were analyzed. Compared to SAVR, TAVR was not associated with all-cause mortality [RR 0.86 (95% CI 0.61–1.19); P = 0.36; I2 = 8%] or stroke [RR 0.82 (0.48–1.43); P = 0.49; I2 = 42%]. However, TAVR was significantly associated with lower risk of acute kidney injury [RR 0.27 (0.13–0.54); P = 0.0002; I2 = 0%], new-onset atrial fibrillation [RR 0.26 (0.18–0.39); P < 0.00001; I2 = 80%], and life-threatening or disabling bleeding [RR 0.35 (0.22–0.55); P < 0.00001; I2 = 57%], but a higher risk of moderate-severe paravalvular leak [RR 4.40 (1.22–15.86); P = 0.02; I2 = 26%] and permanent pacemaker insertion [RR 2.73 (1.41–5.28); P = 0.003; I2 = 83%]. There is no difference in all-cause mortality or stroke between TAVR and SAVR, but TAVR is associated with lower risk of other perioperative complications except for moderate-severe paravalvular leak and the need for permanent pacemaker implantation." @default.
• W2968261569 created "2019-08-22" @default.
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• W2968261569 date "2020-04-01" @default.
• W2968261569 modified "2023-09-26" @default.
• W2968261569 title "Transcatheter Aortic Valve Replacement in Low-Risk Patients: A Meta-Analysis of Randomized Controlled Trials" @default.
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• W2968261569 doi "https://doi.org/10.1016/j.carrev.2019.08.008" @default.
• W2968261569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31447314" @default.
• W2968261569 hasPublicationYear "2020" @default.
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