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- W2968271722 abstract "14128 Background: Chemoradiation (CRT) is now established as the primary treatment for anal carcinoma. The original combination was 5Fu and mitomycin C, but the cisplatin may offer better local control than the standar of MMC with toxicity more tolerable. Methods: Between March 2000 and January 2005, 25 patients with anal carcinoma advanced with non pre-treated were enrolled. Eligible patients had an ECOG PS 0–2. They received cisplatin 80–100 mg/m 2 day 1 and 5FU 800–1000 mg/m 2 day 1–4 every 4 weeks and radiotherapy >45 Gys. Results: 25 patients, 12 male and 13 female, median age 63 (range 36–83 y). 22 with squamous cell carcinoma and 3 adenocarcinoma. (A) 11 patients recieved QT concurrente with RT, median cycles 2 and median of RT 50 Gys and (B) 14 patients recieved QT follow QT-RT concurrent, median cycles 3.5 and median of RT 48 Gys. The toxicity 3–4 were: neutropenia 23%, anaemia 4%, trombocytopenia 8%, diarrhea 15%, vomiting and nausea 19%. The evaluation: (RC) (64%), (RP) (28%) and PD (8%). The median survival 15.5 m (9–42 m), 12 m group A vs 16 m group B. Conclusions: The combination RT-QT with cisplatin and 5FU is feasible and tolerable, and may offer more the secuencie QT follow CRT. No significant financial relationships to disclose." @default.
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- W2968271722 date "2006-06-20" @default.
- W2968271722 modified "2023-09-26" @default.
- W2968271722 title "Chemoradiotherapy in anal carcinoma using cisplatin and 5FU" @default.
- W2968271722 doi "https://doi.org/10.1200/jco.2006.24.18_suppl.14128" @default.
- W2968271722 hasPublicationYear "2006" @default.
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