Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968272899> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2968272899 abstract "Recombinant Inbred Lines (RILs) are obtained through generations of inbreeding until all alleles are fixed. In 1931 Haldane and Waddington published a landmark paper where they provided the probabilities of achieving any combination of alleles in 2-way RILs for 2 and 3 loci. In the case of SIB RILs where sisters and brothers are crossed at each generation, there has been no progress in treating 4 or more loci, a limitation we overcome here without much increase in complexity. In the general situation of $L$ loci, the task is to determine $2^L$ probabilities, but we find that it is necessary to first calculate the $4^L$ ``identical by descent'' (IBD) probabilities that a RIL inherits at each locus its DNA from one of the four originating chromosomes. We show that these $4^L$ probabilities satisfy a system of linear equations that follow from self consistency. In the absence of genetic interference -- crossovers arising independently --, the associated matrix can be written explicitly in terms of the recombination rates between the different loci. We provide the matrices for $L$ up to $4$ and also include a computer program to automatically generate the matrices for higher values of $L$. Furthermore, our framework can be generalized to recombination rates that are different in female and male meiosis which allows us to show that the Haldane and Waddington 2-locus formula is valid in that more subtle case if the meiotic recombination rate is taken as the average rate across female and male. Once the $4^L$ IBD probabilities are determined, the $2^L$ probabilities of RIL genotypes are obtained emph{via} summations of these quantities. emph{In fine}, our computer program allows to determine the probabilities of all the multilocus genotypes produced in such sibling-based RILs for $L le 10$, a huge leap beyond the $L=3$ restriction of Haldane and Waddington." @default.
- W2968272899 created "2019-08-22" @default.
- W2968272899 creator A5005002059 @default.
- W2968272899 creator A5044847011 @default.
- W2968272899 creator A5060944493 @default.
- W2968272899 date "2019-10-01" @default.
- W2968272899 modified "2023-09-25" @default.
- W2968272899 title "Probabilities of Multilocus Genotypes in SIB Recombinant Inbred Lines" @default.
- W2968272899 cites W1576062603 @default.
- W2968272899 cites W1894041544 @default.
- W2968272899 cites W1900944900 @default.
- W2968272899 cites W1969761972 @default.
- W2968272899 cites W2031593666 @default.
- W2968272899 cites W2064186732 @default.
- W2968272899 cites W2106931040 @default.
- W2968272899 cites W2118165948 @default.
- W2968272899 cites W2123466824 @default.
- W2968272899 cites W2125066647 @default.
- W2968272899 cites W2126810330 @default.
- W2968272899 cites W2156336243 @default.
- W2968272899 cites W2163344662 @default.
- W2968272899 cites W2166011336 @default.
- W2968272899 cites W2168757624 @default.
- W2968272899 cites W2891696188 @default.
- W2968272899 doi "https://doi.org/10.3389/fgene.2019.00833" @default.
- W2968272899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6781035" @default.
- W2968272899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31632434" @default.
- W2968272899 hasPublicationYear "2019" @default.
- W2968272899 type Work @default.
- W2968272899 sameAs 2968272899 @default.
- W2968272899 citedByCount "0" @default.
- W2968272899 crossrefType "journal-article" @default.
- W2968272899 hasAuthorship W2968272899A5005002059 @default.
- W2968272899 hasAuthorship W2968272899A5044847011 @default.
- W2968272899 hasAuthorship W2968272899A5060944493 @default.
- W2968272899 hasBestOaLocation W29682728991 @default.
- W2968272899 hasConcept C104317684 @default.
- W2968272899 hasConcept C115220002 @default.
- W2968272899 hasConcept C135763542 @default.
- W2968272899 hasConcept C144024400 @default.
- W2968272899 hasConcept C148196450 @default.
- W2968272899 hasConcept C149923435 @default.
- W2968272899 hasConcept C156695909 @default.
- W2968272899 hasConcept C178221405 @default.
- W2968272899 hasConcept C180754005 @default.
- W2968272899 hasConcept C197754878 @default.
- W2968272899 hasConcept C2777782036 @default.
- W2968272899 hasConcept C2908647359 @default.
- W2968272899 hasConcept C54355233 @default.
- W2968272899 hasConcept C76725341 @default.
- W2968272899 hasConcept C84597430 @default.
- W2968272899 hasConcept C86803240 @default.
- W2968272899 hasConceptScore W2968272899C104317684 @default.
- W2968272899 hasConceptScore W2968272899C115220002 @default.
- W2968272899 hasConceptScore W2968272899C135763542 @default.
- W2968272899 hasConceptScore W2968272899C144024400 @default.
- W2968272899 hasConceptScore W2968272899C148196450 @default.
- W2968272899 hasConceptScore W2968272899C149923435 @default.
- W2968272899 hasConceptScore W2968272899C156695909 @default.
- W2968272899 hasConceptScore W2968272899C178221405 @default.
- W2968272899 hasConceptScore W2968272899C180754005 @default.
- W2968272899 hasConceptScore W2968272899C197754878 @default.
- W2968272899 hasConceptScore W2968272899C2777782036 @default.
- W2968272899 hasConceptScore W2968272899C2908647359 @default.
- W2968272899 hasConceptScore W2968272899C54355233 @default.
- W2968272899 hasConceptScore W2968272899C76725341 @default.
- W2968272899 hasConceptScore W2968272899C84597430 @default.
- W2968272899 hasConceptScore W2968272899C86803240 @default.
- W2968272899 hasLocation W29682728991 @default.
- W2968272899 hasLocation W29682728992 @default.
- W2968272899 hasLocation W29682728993 @default.
- W2968272899 hasLocation W29682728994 @default.
- W2968272899 hasLocation W29682728995 @default.
- W2968272899 hasLocation W29682728996 @default.
- W2968272899 hasOpenAccess W2968272899 @default.
- W2968272899 hasPrimaryLocation W29682728991 @default.
- W2968272899 hasRelatedWork W1505316652 @default.
- W2968272899 hasRelatedWork W1555027860 @default.
- W2968272899 hasRelatedWork W1965754344 @default.
- W2968272899 hasRelatedWork W2014290388 @default.
- W2968272899 hasRelatedWork W2057739827 @default.
- W2968272899 hasRelatedWork W2087118228 @default.
- W2968272899 hasRelatedWork W2099806749 @default.
- W2968272899 hasRelatedWork W2120777818 @default.
- W2968272899 hasRelatedWork W2156336243 @default.
- W2968272899 hasRelatedWork W2160397906 @default.
- W2968272899 hasVolume "10" @default.
- W2968272899 isParatext "false" @default.
- W2968272899 isRetracted "false" @default.
- W2968272899 magId "2968272899" @default.
- W2968272899 workType "article" @default.