Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968294890> ?p ?o ?g. }
- W2968294890 endingPage "1883" @default.
- W2968294890 startingPage "1877" @default.
- W2968294890 abstract "The antihypertensive activity of two αs1-casein-derived peptides and casein hydrolysate containing these sequences was evaluated in the presence of naloxone. The activity was abolished by this opioid antagonist at 2, 4, and 6 h post-administration. Similarly, the antihypertensive effect of the αs1-casein peptides 90RYLGY94 (−23.8 ± 2.5 mmHg) and 143AYFYPEL149 (−21.1 ± 3.2 mmHg) at 5 mg/kg of body weight was antagonized by the co-administration of naloxone. Because peptide 143AYFYPEL149 had recently shown opioid activity, a molecular dynamic simulation of this peptide with human μ-opioid receptor was performed to demonstrate its favorable structure and interaction energy, despite the presence of Ala at the N terminus. Altogether, these results revealed that the in vivo effect on systolic blood pressure of the studied αs1-casein peptides is mediated by interaction with opioid receptors and the antihypertensive activity of casein hydrolysate can be very likely ascribed to them with the possible contribution of other mechanisms." @default.
- W2968294890 created "2019-08-22" @default.
- W2968294890 creator A5001575665 @default.
- W2968294890 creator A5015598652 @default.
- W2968294890 creator A5034433255 @default.
- W2968294890 creator A5042061868 @default.
- W2968294890 creator A5057478972 @default.
- W2968294890 creator A5071961810 @default.
- W2968294890 date "2019-08-11" @default.
- W2968294890 modified "2023-10-02" @default.
- W2968294890 title "Implication of Opioid Receptors in the Antihypertensive Effect of a Bovine Casein Hydrolysate and α<sub>s1</sub>-Casein-Derived Peptides" @default.
- W2968294890 cites W1633068456 @default.
- W2968294890 cites W1875962589 @default.
- W2968294890 cites W1918796765 @default.
- W2968294890 cites W1996042213 @default.
- W2968294890 cites W2001862039 @default.
- W2968294890 cites W2006944115 @default.
- W2968294890 cites W2012840565 @default.
- W2968294890 cites W2019157563 @default.
- W2968294890 cites W2021155760 @default.
- W2968294890 cites W2022871517 @default.
- W2968294890 cites W2026316006 @default.
- W2968294890 cites W2026773886 @default.
- W2968294890 cites W2037596260 @default.
- W2968294890 cites W2045048871 @default.
- W2968294890 cites W2056083730 @default.
- W2968294890 cites W2057832802 @default.
- W2968294890 cites W2064487479 @default.
- W2968294890 cites W2076319878 @default.
- W2968294890 cites W2087120563 @default.
- W2968294890 cites W2096335789 @default.
- W2968294890 cites W2099407616 @default.
- W2968294890 cites W2107642672 @default.
- W2968294890 cites W2110334716 @default.
- W2968294890 cites W2123339576 @default.
- W2968294890 cites W2128107708 @default.
- W2968294890 cites W2162992772 @default.
- W2968294890 cites W2168269595 @default.
- W2968294890 cites W2257896976 @default.
- W2968294890 cites W2463789905 @default.
- W2968294890 cites W2690578411 @default.
- W2968294890 cites W2766326401 @default.
- W2968294890 cites W2775228160 @default.
- W2968294890 cites W2778946901 @default.
- W2968294890 cites W2791832674 @default.
- W2968294890 cites W2888016684 @default.
- W2968294890 cites W813064803 @default.
- W2968294890 cites W983940470 @default.
- W2968294890 doi "https://doi.org/10.1021/acs.jafc.9b03872" @default.
- W2968294890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31402656" @default.
- W2968294890 hasPublicationYear "2019" @default.
- W2968294890 type Work @default.
- W2968294890 sameAs 2968294890 @default.
- W2968294890 citedByCount "16" @default.
- W2968294890 countsByYear W29682948902019 @default.
- W2968294890 countsByYear W29682948902021 @default.
- W2968294890 countsByYear W29682948902022 @default.
- W2968294890 countsByYear W29682948902023 @default.
- W2968294890 crossrefType "journal-article" @default.
- W2968294890 hasAuthorship W2968294890A5001575665 @default.
- W2968294890 hasAuthorship W2968294890A5015598652 @default.
- W2968294890 hasAuthorship W2968294890A5034433255 @default.
- W2968294890 hasAuthorship W2968294890A5042061868 @default.
- W2968294890 hasAuthorship W2968294890A5057478972 @default.
- W2968294890 hasAuthorship W2968294890A5071961810 @default.
- W2968294890 hasConcept C134018914 @default.
- W2968294890 hasConcept C150903083 @default.
- W2968294890 hasConcept C170493617 @default.
- W2968294890 hasConcept C185592680 @default.
- W2968294890 hasConcept C207001950 @default.
- W2968294890 hasConcept C2776142715 @default.
- W2968294890 hasConcept C2776885963 @default.
- W2968294890 hasConcept C2778750930 @default.
- W2968294890 hasConcept C2779281246 @default.
- W2968294890 hasConcept C2779886867 @default.
- W2968294890 hasConcept C2781063702 @default.
- W2968294890 hasConcept C28800991 @default.
- W2968294890 hasConcept C55493867 @default.
- W2968294890 hasConcept C71924100 @default.
- W2968294890 hasConcept C86803240 @default.
- W2968294890 hasConcept C88016717 @default.
- W2968294890 hasConcept C94412978 @default.
- W2968294890 hasConcept C98274493 @default.
- W2968294890 hasConceptScore W2968294890C134018914 @default.
- W2968294890 hasConceptScore W2968294890C150903083 @default.
- W2968294890 hasConceptScore W2968294890C170493617 @default.
- W2968294890 hasConceptScore W2968294890C185592680 @default.
- W2968294890 hasConceptScore W2968294890C207001950 @default.
- W2968294890 hasConceptScore W2968294890C2776142715 @default.
- W2968294890 hasConceptScore W2968294890C2776885963 @default.
- W2968294890 hasConceptScore W2968294890C2778750930 @default.
- W2968294890 hasConceptScore W2968294890C2779281246 @default.
- W2968294890 hasConceptScore W2968294890C2779886867 @default.
- W2968294890 hasConceptScore W2968294890C2781063702 @default.
- W2968294890 hasConceptScore W2968294890C28800991 @default.
- W2968294890 hasConceptScore W2968294890C55493867 @default.
- W2968294890 hasConceptScore W2968294890C71924100 @default.
- W2968294890 hasConceptScore W2968294890C86803240 @default.