Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968298797> ?p ?o ?g. }
- W2968298797 endingPage "6100" @default.
- W2968298797 startingPage "6090" @default.
- W2968298797 abstract "Abstract Context Women with HIV (WHIV) on anti-retroviral therapy (ART) are living longer but facing heightened vulnerability to heart failure. Objective We investigated metabolic/hormonal/immune parameters relating to diastolic dysfunction—a precursor to heart failure—among WHIV without known cardiovascular disease (CVD). Design and Outcome Measures Nineteen ART-treated WHIV and 11 non-HIV-infected women without known CVD enrolled and successfully completed relevant study procedures [cardiac magnetic resonance spectroscopy (MRS) and cardiac MRI]. Groups were matched on age and body mass index. Primary outcome measures included intramyocardial triglyceride content (cardiac MRS) and diastolic function (cardiac MRI). Relationships between intramyocardial triglyceride content and clinical parameters were also assessed. Results Among WHIV (vs non-HIV-infected women), intramyocardial triglyceride content was threefold higher [1.2 (0.4, 3.1) vs 0.4 (0.1, 0.5)%, P = 0.01], and diastolic function was reduced (left atrial passive ejection fraction: 27.2 ± 9.6 vs 35.9 ± 6.4%, P = 0.007). There was a strong inverse relationship between intramyocardial triglyceride content and diastolic function (ρ = −0.62, P = 0.004). Among the whole group, intramyocardial triglyceride content did not relate to chronologic age but did increase across the reproductive aging spectrum (P = 0.02). HIV status and reproductive aging status remained independent predictors of intramyocardial triglyceride content after adjusting for relevant cardiometabolic parameters (overall model R2 = 0.56, P = 0.003; HIV status P = 0.01, reproductive aging status P = 0.02). Conclusions For asymptomatic WHIV, increased intramyocardial triglyceride content is associated with diastolic dysfunction. Moreover, relationships between intramyocardial triglyceride accumulation and women’s reproductive aging are noted." @default.
- W2968298797 created "2019-08-22" @default.
- W2968298797 creator A5002243325 @default.
- W2968298797 creator A5004356613 @default.
- W2968298797 creator A5006040487 @default.
- W2968298797 creator A5007440108 @default.
- W2968298797 creator A5010936484 @default.
- W2968298797 creator A5014118695 @default.
- W2968298797 creator A5024760960 @default.
- W2968298797 creator A5026811038 @default.
- W2968298797 creator A5034813577 @default.
- W2968298797 creator A5047137718 @default.
- W2968298797 creator A5063741883 @default.
- W2968298797 creator A5066688363 @default.
- W2968298797 creator A5066733224 @default.
- W2968298797 creator A5080708954 @default.
- W2968298797 creator A5087164932 @default.
- W2968298797 creator A5090915853 @default.
- W2968298797 date "2019-08-08" @default.
- W2968298797 modified "2023-10-14" @default.
- W2968298797 title "Intramyocardial Triglycerides Among Women With vs Without HIV: Hormonal Correlates and Functional Consequences" @default.
- W2968298797 cites W1772253419 @default.
- W2968298797 cites W1951521958 @default.
- W2968298797 cites W1987015387 @default.
- W2968298797 cites W1994291970 @default.
- W2968298797 cites W1997983515 @default.
- W2968298797 cites W2005272368 @default.
- W2968298797 cites W2006205217 @default.
- W2968298797 cites W2014387233 @default.
- W2968298797 cites W2016336666 @default.
- W2968298797 cites W2018903719 @default.
- W2968298797 cites W2019071303 @default.
- W2968298797 cites W2050452134 @default.
- W2968298797 cites W2053105417 @default.
- W2968298797 cites W2056759532 @default.
- W2968298797 cites W2057547167 @default.
- W2968298797 cites W2059010165 @default.
- W2968298797 cites W2064516418 @default.
- W2968298797 cites W2067638840 @default.
- W2968298797 cites W2069824181 @default.
- W2968298797 cites W2072270220 @default.
- W2968298797 cites W2076569224 @default.
- W2968298797 cites W2087701915 @default.
- W2968298797 cites W2115452297 @default.
- W2968298797 cites W2131451412 @default.
- W2968298797 cites W2139178927 @default.
- W2968298797 cites W2148516473 @default.
- W2968298797 cites W2152465587 @default.
- W2968298797 cites W2161656900 @default.
- W2968298797 cites W2164086622 @default.
- W2968298797 cites W2167777123 @default.
- W2968298797 cites W2231913169 @default.
- W2968298797 cites W2235324660 @default.
- W2968298797 cites W2239031272 @default.
- W2968298797 cites W2318038286 @default.
- W2968298797 cites W2466151179 @default.
- W2968298797 cites W2473860793 @default.
- W2968298797 cites W2519438674 @default.
- W2968298797 cites W2531567355 @default.
- W2968298797 cites W2531619540 @default.
- W2968298797 cites W2548379368 @default.
- W2968298797 cites W2568737359 @default.
- W2968298797 cites W2588757737 @default.
- W2968298797 cites W2626234668 @default.
- W2968298797 cites W2745358467 @default.
- W2968298797 cites W2755760415 @default.
- W2968298797 cites W2763576067 @default.
- W2968298797 cites W2778647326 @default.
- W2968298797 cites W2789727743 @default.
- W2968298797 cites W2794525420 @default.
- W2968298797 cites W2795006468 @default.
- W2968298797 cites W2795436691 @default.
- W2968298797 cites W2805528526 @default.
- W2968298797 cites W2922860464 @default.
- W2968298797 cites W2941827326 @default.
- W2968298797 cites W4229608423 @default.
- W2968298797 doi "https://doi.org/10.1210/jc.2019-01096" @default.
- W2968298797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6954489" @default.
- W2968298797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31393564" @default.
- W2968298797 hasPublicationYear "2019" @default.
- W2968298797 type Work @default.
- W2968298797 sameAs 2968298797 @default.
- W2968298797 citedByCount "20" @default.
- W2968298797 countsByYear W29682987972019 @default.
- W2968298797 countsByYear W29682987972020 @default.
- W2968298797 countsByYear W29682987972021 @default.
- W2968298797 countsByYear W29682987972022 @default.
- W2968298797 countsByYear W29682987972023 @default.
- W2968298797 crossrefType "journal-article" @default.
- W2968298797 hasAuthorship W2968298797A5002243325 @default.
- W2968298797 hasAuthorship W2968298797A5004356613 @default.
- W2968298797 hasAuthorship W2968298797A5006040487 @default.
- W2968298797 hasAuthorship W2968298797A5007440108 @default.
- W2968298797 hasAuthorship W2968298797A5010936484 @default.
- W2968298797 hasAuthorship W2968298797A5014118695 @default.
- W2968298797 hasAuthorship W2968298797A5024760960 @default.
- W2968298797 hasAuthorship W2968298797A5026811038 @default.
- W2968298797 hasAuthorship W2968298797A5034813577 @default.