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- W2968299329 abstract "Abstract Acinetobacter baumannii is an opportunistic pathogen which plays crucial roles in nosocomial infections and hospital outbreaks. The study aimed to determine the presence of virulence factors and the ability of biofilm production by isolated A. baumannii from hospitalized patients. The prevalence of A. baumannii in clinical samples was identified with standard biochemical tests. Polymerase chain reaction (PCR) was used for investigation of the presence of virulence factors in isolated strains. The isolates were assayed for biofilm formation by microtiter plate method. Totally, 100 clinical isolates of A. baumannii were collected. Although the presence of iutA (10%) and papC (5%) virulence genes was confirmed by PCR, isolated A. baumannii were negative for cnf1, cnf2, fbn, and kpsMT II virulence factors. Moreover, the quantification of biofilm production showed that 61% of the isolates were able to produce biofilm. Also, there was no relationship between the presence of iutA and papC genes and biofilm formation. In summary, we identified a high prevalence of biofilm formation among clinical isolates of A. baumannii in southwest of Iran, which could guarantee their persistence in the hospital environment. Our findings revealed that iutA and papC virulence genes which are associated with iron uptake and fimbriae can contribute to the pathogenesis of A. baumannii isolates in our region. It seems that effective infection control measures are essential to overcome the rapid dissemination of A. baumannii in our hospitals." @default.
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- W2968299329 date "2019-12-01" @default.
- W2968299329 modified "2023-09-24" @default.
- W2968299329 title "Virulence genes profile and biofilm formation ability of Acinetobacter baumannii strains isolated from inpatients of a tertiary care hospital in southwest of Iran" @default.
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- W2968299329 doi "https://doi.org/10.1016/j.genrep.2019.100481" @default.
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