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- W2968300883 endingPage "895" @default.
- W2968300883 startingPage "895" @default.
- W2968300883 abstract "The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease. Here, we review the functions mediated by ligand-induced IGF axis activation, and discuss the evidence for the involvement of IGF signaling in the pathogenesis of cancer, endocrine disorders including acromegaly, diabetes and thyroid eye disease, skin diseases such as acne and psoriasis, and the frailty that accompanies aging. We discuss the use of IGF axis inhibitors, focusing on the different approaches that have been taken to develop effective and tolerable ways to block this important signaling pathway. We outline the advantages and disadvantages of each approach, and discuss progress in evaluating these agents, including factors that contributed to the failure of many of these novel therapeutics in early phase cancer trials. Finally, we summarize grounds for cautious optimism for ongoing and future studies of IGF blockade in cancer and non-malignant disorders including thyroid eye disease and aging." @default.
- W2968300883 created "2019-08-22" @default.
- W2968300883 creator A5008101298 @default.
- W2968300883 creator A5089789570 @default.
- W2968300883 date "2019-08-14" @default.
- W2968300883 modified "2023-10-11" @default.
- W2968300883 title "Therapeutic Targeting of the IGF Axis" @default.
- W2968300883 cites W1521170911 @default.
- W2968300883 cites W1531403985 @default.
- W2968300883 cites W1545276407 @default.
- W2968300883 cites W1547298604 @default.
- W2968300883 cites W1551848109 @default.
- W2968300883 cites W1555659680 @default.
- W2968300883 cites W1562838305 @default.
- W2968300883 cites W1583743328 @default.
- W2968300883 cites W1590127176 @default.
- W2968300883 cites W1595230061 @default.
- W2968300883 cites W1595424043 @default.
- W2968300883 cites W1611419331 @default.
- W2968300883 cites W1647075334 @default.
- W2968300883 cites W1774852205 @default.
- W2968300883 cites W1835811038 @default.
- W2968300883 cites W1836586572 @default.
- W2968300883 cites W1861705388 @default.
- W2968300883 cites W1875199757 @default.
- W2968300883 cites W1916328219 @default.
- W2968300883 cites W1930521840 @default.
- W2968300883 cites W1931843124 @default.
- W2968300883 cites W1945007559 @default.
- W2968300883 cites W1963513953 @default.
- W2968300883 cites W1964345362 @default.
- W2968300883 cites W1966329249 @default.
- W2968300883 cites W1969646312 @default.
- W2968300883 cites W1970009324 @default.
- W2968300883 cites W1971736092 @default.
- W2968300883 cites W1973821188 @default.
- W2968300883 cites W1975736029 @default.
- W2968300883 cites W1976143235 @default.
- W2968300883 cites W1977127668 @default.
- W2968300883 cites W1980725734 @default.
- W2968300883 cites W1980788326 @default.
- W2968300883 cites W1985425785 @default.
- W2968300883 cites W1985905712 @default.
- W2968300883 cites W1988477501 @default.
- W2968300883 cites W1993199678 @default.
- W2968300883 cites W1993672117 @default.
- W2968300883 cites W1995870656 @default.
- W2968300883 cites W1997146974 @default.
- W2968300883 cites W1998665155 @default.
- W2968300883 cites W1999030960 @default.
- W2968300883 cites W1999455768 @default.
- W2968300883 cites W2003946492 @default.
- W2968300883 cites W2005031444 @default.
- W2968300883 cites W2005890897 @default.
- W2968300883 cites W2006827588 @default.
- W2968300883 cites W2010296481 @default.
- W2968300883 cites W2010399667 @default.
- W2968300883 cites W2012730900 @default.
- W2968300883 cites W2014801535 @default.
- W2968300883 cites W2017154680 @default.
- W2968300883 cites W2017536128 @default.
- W2968300883 cites W2017949036 @default.
- W2968300883 cites W2021942056 @default.
- W2968300883 cites W2027917980 @default.
- W2968300883 cites W2029490796 @default.
- W2968300883 cites W2031373028 @default.
- W2968300883 cites W2038720758 @default.
- W2968300883 cites W2041007000 @default.
- W2968300883 cites W2044313879 @default.
- W2968300883 cites W2044681499 @default.
- W2968300883 cites W2045452812 @default.
- W2968300883 cites W2045483550 @default.
- W2968300883 cites W2047069052 @default.
- W2968300883 cites W2050323318 @default.
- W2968300883 cites W2052432810 @default.
- W2968300883 cites W2054371666 @default.
- W2968300883 cites W2055624165 @default.
- W2968300883 cites W2056854271 @default.
- W2968300883 cites W2057418848 @default.
- W2968300883 cites W2058228760 @default.
- W2968300883 cites W2059030688 @default.
- W2968300883 cites W2065774446 @default.
- W2968300883 cites W2069471041 @default.
- W2968300883 cites W2071910975 @default.
- W2968300883 cites W2074111028 @default.
- W2968300883 cites W2075254346 @default.
- W2968300883 cites W2076133821 @default.
- W2968300883 cites W2076479500 @default.
- W2968300883 cites W2078095800 @default.
- W2968300883 cites W2078462846 @default.
- W2968300883 cites W2080639894 @default.
- W2968300883 cites W2080703915 @default.
- W2968300883 cites W2083932352 @default.
- W2968300883 cites W2085626804 @default.
- W2968300883 cites W2086344146 @default.
- W2968300883 cites W2088977314 @default.
- W2968300883 cites W2091874984 @default.
- W2968300883 cites W2092549650 @default.