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• W2968343885 abstract "During the course of screening for new metabolites from basidiomycetes, we isolated and characterized five previously undescribed secondary metabolites, skeletocutins M–Q ( 1 – 5 ), along with the known metabolite tyromycin A ( 6 ) from the fruiting bodies of the polypore Skeletocutis sp. The new compounds did not exhibit any antimicrobial, cytotoxic, or nematicidal activities. However, compound 3 moderately inhibited the biofilm formation of Staphylococcus aureus ( S. aureus ), while compounds 3 and 4 performed moderately in the ʟ-leucine-7-amido-4-methylcoumarin (ʟ-Leu-AMC) inhibition assay. These compounds represent the first secondary metabolites reported to occur in the fruiting bodies by Skeletocutis . Interestingly, tyromycin A ( 6 ) was found to be the only common metabolite in fruiting bodies and mycelial cultures of the fungus, and none of the recently reported skeletocutins from the culture of the same strain were detected in the basidiomes." @default.
• W2968343885 created "2019-08-22" @default.
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• W2968343885 date "2019-11-19" @default.
• W2968343885 modified "2023-09-30" @default.
• W2968343885 title "Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete <i>Skeletocutis</i> sp. collected in Africa" @default.
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• W2968343885 doi "https://doi.org/10.3762/bjoc.15.270" @default.
• W2968343885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6880814" @default.
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