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- W2968383492 abstract "Pulmonary sarcomatoid carcinoma (PSC) represents <1% of all lung cancers and is characterized by a very poor prognosis. The optimal therapeutic regimen remains unclear. We describe a rare case of PSC with both anaplastic lymphoma kinase (ALK)-arranged and high levels of programmed death ligand 1 (PD-L1) expression.A 46-year-old woman, nonsmoker, came to our attention due to uncontrolled pain in the lower left limb.PSC with both ALK rearrangement and high levels of PD-L1 expression.The patient started first-line systemic treatment with pembrolizumab reporting stable disease; at progression, she received second-line treatment with crizotinib. The treatment was not well-tolerated, and the patient then underwent 5 cycles of ceritinib treatment.The patient showed a partial response to targeted therapy. At progression, brigatinib was initiated, but the patients reported liver progression soon after the initiation of this therapy.Molecular-driven investigation is necessary in PSC for treatment selection." @default.
- W2968383492 created "2019-08-22" @default.
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- W2968383492 date "2019-08-01" @default.
- W2968383492 modified "2023-10-16" @default.
- W2968383492 title "Pulmonary sarcomatoid carcinoma presenting both ALK rearrangement and PD-L1 high positivity" @default.
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- W2968383492 doi "https://doi.org/10.1097/md.0000000000016754" @default.
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