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- W2968408085 abstract "Abstract The importance of the perturbed flow in the human cardiovascular biomechanics is well established in the literature. The endothelial shear stress resulting from blood flow recirculation has been correlated to a considerable number of cardiovascular disorders such as atherosclerosis, stroke and aneurysm, among others. Local hemodynamic and structural factors have been found to promote the initiation and/or development of these pathologies. Traditionally, the modeling of vessel structure and hemodynamics has been accomplished separately due to the complexity of the problem. Computational fluid dynamics (CFD) simulations assume, in fact, rigid walls and do not take the volume buffering of the arteries into account. Fluid-structure interaction simulations add the wall movement through combined structural analysis, also called computational solid mechanics, and CFD computations. This approach increases the complexity and the computational costs of the simulations but leads to more realistic results. Hemodynamics variables such as endothelial shear stress and related indexes are evaluated here for two human vessels such as the aorta and the carotid artery, demonstrating their dependence on arterial compliance yet assessing the relevance of including the vessel walls. In addition, the simultaneous estimation of the wall shear stress and of the maximum principal stress allows the analysis of correlated fluid and mechanical stimuli for different clinical applications that range from a general purpose of investigating cardiovascular diseases to more defined and personalized goals such as the creation of surgical planning for a specific patient." @default.
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- W2968408085 date "2019-01-01" @default.
- W2968408085 modified "2023-10-17" @default.
- W2968408085 title "Impact of the Fluid-Structure Interaction Modeling on the Human Vessel Hemodynamics" @default.
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- W2968408085 doi "https://doi.org/10.1016/b978-0-12-816390-0.00005-4" @default.
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