Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968425087> ?p ?o ?g. }
- W2968425087 endingPage "894" @default.
- W2968425087 startingPage "894" @default.
- W2968425087 abstract "Nucleolar stress is a cellular response to inhibition of ribosome biogenesis or nucleolar disruption leading to cell cycle arrest and/or apoptosis. Emerging evidence points to a tight connection between nucleolar stress and autophagy as a mechanism underlying various diseases such as neurodegeneration and treatment of cancer. Peter Pan (PPAN) functions as a key regulator of ribosome biogenesis. We previously showed that human PPAN localizes to nucleoli and mitochondria and that PPAN knockdown triggers a p53-independent nucleolar stress response culminating in mitochondrial apoptosis. Here, we demonstrate a novel role of PPAN in the regulation of mitochondrial homeostasis and autophagy. Our present study characterizes PPAN as a factor required for maintaining mitochondrial integrity and respiration-coupled ATP production. PPAN interacts with cardiolipin, a lipid of the inner mitochondrial membrane. Down-regulation of PPAN enhances autophagic flux in cancer cells. PPAN knockdown promotes recruitment of the E3-ubiquitin ligase Parkin to damaged mitochondria. Moreover, we provide evidence that PPAN knockdown decreases mitochondrial mass in Parkin-expressing cells. In summary, our study uncovers that PPAN knockdown is linked to mitochondrial damage and stimulates autophagy." @default.
- W2968425087 created "2019-08-22" @default.
- W2968425087 creator A5005345616 @default.
- W2968425087 creator A5022410156 @default.
- W2968425087 creator A5051644947 @default.
- W2968425087 creator A5059927620 @default.
- W2968425087 creator A5068224616 @default.
- W2968425087 creator A5070758909 @default.
- W2968425087 date "2019-08-14" @default.
- W2968425087 modified "2023-10-16" @default.
- W2968425087 title "Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux" @default.
- W2968425087 cites W1003328989 @default.
- W2968425087 cites W1558103114 @default.
- W2968425087 cites W1562156325 @default.
- W2968425087 cites W1569409978 @default.
- W2968425087 cites W1690638120 @default.
- W2968425087 cites W1852699976 @default.
- W2968425087 cites W1860864010 @default.
- W2968425087 cites W1929336150 @default.
- W2968425087 cites W1966242253 @default.
- W2968425087 cites W1969065515 @default.
- W2968425087 cites W1969438919 @default.
- W2968425087 cites W1969468821 @default.
- W2968425087 cites W1970945068 @default.
- W2968425087 cites W1972440163 @default.
- W2968425087 cites W1976921001 @default.
- W2968425087 cites W1986163669 @default.
- W2968425087 cites W1990619980 @default.
- W2968425087 cites W1992091494 @default.
- W2968425087 cites W1998259272 @default.
- W2968425087 cites W1999477136 @default.
- W2968425087 cites W1999962568 @default.
- W2968425087 cites W2001591494 @default.
- W2968425087 cites W2001675597 @default.
- W2968425087 cites W2002373110 @default.
- W2968425087 cites W2006415258 @default.
- W2968425087 cites W2012774065 @default.
- W2968425087 cites W2013091489 @default.
- W2968425087 cites W2015897559 @default.
- W2968425087 cites W2022063924 @default.
- W2968425087 cites W2025665129 @default.
- W2968425087 cites W2032026823 @default.
- W2968425087 cites W2032700869 @default.
- W2968425087 cites W2033596616 @default.
- W2968425087 cites W2034912564 @default.
- W2968425087 cites W2035184193 @default.
- W2968425087 cites W2045871231 @default.
- W2968425087 cites W2048021703 @default.
- W2968425087 cites W2048297293 @default.
- W2968425087 cites W2049868418 @default.
- W2968425087 cites W2050546395 @default.
- W2968425087 cites W2052468549 @default.
- W2968425087 cites W2059738518 @default.
- W2968425087 cites W2059755379 @default.
- W2968425087 cites W2059958613 @default.
- W2968425087 cites W2061441903 @default.
- W2968425087 cites W2063362926 @default.
- W2968425087 cites W2069403245 @default.
- W2968425087 cites W2074329998 @default.
- W2968425087 cites W2076769172 @default.
- W2968425087 cites W2082425146 @default.
- W2968425087 cites W2089818400 @default.
- W2968425087 cites W2089977692 @default.
- W2968425087 cites W2093650005 @default.
- W2968425087 cites W2096128324 @default.
- W2968425087 cites W2100893053 @default.
- W2968425087 cites W2103230459 @default.
- W2968425087 cites W2104412320 @default.
- W2968425087 cites W2106444069 @default.
- W2968425087 cites W2107554012 @default.
- W2968425087 cites W2108244474 @default.
- W2968425087 cites W2117962408 @default.
- W2968425087 cites W2118849726 @default.
- W2968425087 cites W2121469024 @default.
- W2968425087 cites W2134359750 @default.
- W2968425087 cites W2135592618 @default.
- W2968425087 cites W2139329774 @default.
- W2968425087 cites W2142845200 @default.
- W2968425087 cites W2145432623 @default.
- W2968425087 cites W2147160088 @default.
- W2968425087 cites W2155015733 @default.
- W2968425087 cites W2155366353 @default.
- W2968425087 cites W2161080023 @default.
- W2968425087 cites W2172786635 @default.
- W2968425087 cites W2234186811 @default.
- W2968425087 cites W2240173075 @default.
- W2968425087 cites W2300430609 @default.
- W2968425087 cites W2464336937 @default.
- W2968425087 cites W2525697724 @default.
- W2968425087 cites W2571047259 @default.
- W2968425087 cites W2579317571 @default.
- W2968425087 cites W2584215338 @default.
- W2968425087 cites W2602035017 @default.
- W2968425087 cites W2616578517 @default.
- W2968425087 cites W2752326209 @default.
- W2968425087 cites W2769523034 @default.
- W2968425087 cites W2780904926 @default.
- W2968425087 cites W2785105763 @default.