Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968439743> ?p ?o ?g. }
- W2968439743 endingPage "2356" @default.
- W2968439743 startingPage "2340" @default.
- W2968439743 abstract "Retinopathy of prematurity (ROP) is characterized by an initial retinal avascularization, followed by pathologic neovascularization. Recently, choroidal thinning has also been detected in children formerly diagnosed with ROP; a similar sustained choroidal thinning is observed in ROP models. But the mechanism underlying the lack of choroidal revascularization remains unclear and was investigated in an oxygen-induced retinopathy (OIR) model. In OIR, evidence of senescence was detected, preceded by oxidative stress in the choroid and the retinal pigment epithelium. This was associated with a global reduction of proangiogenic factors, including insulin-like growth factor 1 receptor (Igf1R). Coincidentally, tumor suppressor p53 was highly expressed in the OIR retinae. Curtailing p53 activity resulted in reversal of senescence, normalization of Igf1r expression, and preservation of choroidal integrity. OIR-induced down-regulation of Igf1r was mediated at least partly by miR-let-7b as i) let-7b expression was augmented throughout and beyond the period of oxygen exposure, ii) let-7b directly targeted Igf1r mRNA, and iii) p53 knock-down blunted let-7b expression, restored Igf1r expression, and elicited choroidal revascularization. Finally, restoration of Igf1r expression rescued choroid thickness. Altogether, this study uncovers a significant mechanism for defective choroidal revascularization in OIR, revealing a new role for p53/let-7b/IGF-1R axis in the retina. Future investigations on this (and connected) pathway could further our understanding of other degenerative choroidopathies, such as geographic atrophy." @default.
- W2968439743 created "2019-08-22" @default.
- W2968439743 creator A5004357574 @default.
- W2968439743 creator A5007545695 @default.
- W2968439743 creator A5017109197 @default.
- W2968439743 creator A5020435491 @default.
- W2968439743 creator A5020684571 @default.
- W2968439743 creator A5041894696 @default.
- W2968439743 creator A5056681768 @default.
- W2968439743 creator A5060561821 @default.
- W2968439743 creator A5061187310 @default.
- W2968439743 creator A5064311226 @default.
- W2968439743 creator A5067092778 @default.
- W2968439743 creator A5067115954 @default.
- W2968439743 creator A5081622849 @default.
- W2968439743 creator A5087627325 @default.
- W2968439743 creator A5090449465 @default.
- W2968439743 date "2019-11-01" @default.
- W2968439743 modified "2023-10-02" @default.
- W2968439743 title "The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b Activity" @default.
- W2968439743 cites W1524571013 @default.
- W2968439743 cites W1584507323 @default.
- W2968439743 cites W1591955804 @default.
- W2968439743 cites W1686601736 @default.
- W2968439743 cites W1775759920 @default.
- W2968439743 cites W1965718763 @default.
- W2968439743 cites W1968008181 @default.
- W2968439743 cites W1969524738 @default.
- W2968439743 cites W1970431885 @default.
- W2968439743 cites W1972651881 @default.
- W2968439743 cites W1985425785 @default.
- W2968439743 cites W1986363023 @default.
- W2968439743 cites W1988349721 @default.
- W2968439743 cites W1994429692 @default.
- W2968439743 cites W1995340861 @default.
- W2968439743 cites W2003505482 @default.
- W2968439743 cites W2003999217 @default.
- W2968439743 cites W2007763447 @default.
- W2968439743 cites W2027172016 @default.
- W2968439743 cites W2033632929 @default.
- W2968439743 cites W2033813554 @default.
- W2968439743 cites W2037846776 @default.
- W2968439743 cites W2041280548 @default.
- W2968439743 cites W2041634501 @default.
- W2968439743 cites W2045338351 @default.
- W2968439743 cites W2046989794 @default.
- W2968439743 cites W2049566750 @default.
- W2968439743 cites W2051435072 @default.
- W2968439743 cites W2053098204 @default.
- W2968439743 cites W2064147974 @default.
- W2968439743 cites W2070985735 @default.
- W2968439743 cites W2071603995 @default.
- W2968439743 cites W2073002561 @default.
- W2968439743 cites W2073276299 @default.
- W2968439743 cites W2076151830 @default.
- W2968439743 cites W2078843582 @default.
- W2968439743 cites W2083407341 @default.
- W2968439743 cites W2083796374 @default.
- W2968439743 cites W2085020132 @default.
- W2968439743 cites W2085707549 @default.
- W2968439743 cites W2093014461 @default.
- W2968439743 cites W2093229250 @default.
- W2968439743 cites W2093398011 @default.
- W2968439743 cites W2093775600 @default.
- W2968439743 cites W2095370504 @default.
- W2968439743 cites W2100251649 @default.
- W2968439743 cites W2101861123 @default.
- W2968439743 cites W2102684430 @default.
- W2968439743 cites W2108929261 @default.
- W2968439743 cites W2112431699 @default.
- W2968439743 cites W2117868576 @default.
- W2968439743 cites W2133409869 @default.
- W2968439743 cites W2135518377 @default.
- W2968439743 cites W2145578278 @default.
- W2968439743 cites W2146483998 @default.
- W2968439743 cites W2146558971 @default.
- W2968439743 cites W2147754866 @default.
- W2968439743 cites W2150881491 @default.
- W2968439743 cites W2153172903 @default.
- W2968439743 cites W2153259848 @default.
- W2968439743 cites W2162437451 @default.
- W2968439743 cites W2170229434 @default.
- W2968439743 cites W2171186404 @default.
- W2968439743 cites W2171524333 @default.
- W2968439743 cites W2182645989 @default.
- W2968439743 cites W2254887604 @default.
- W2968439743 cites W2329967976 @default.
- W2968439743 cites W2413033561 @default.
- W2968439743 cites W2470530881 @default.
- W2968439743 cites W2522889752 @default.
- W2968439743 cites W2535024747 @default.
- W2968439743 cites W2623303663 @default.
- W2968439743 cites W2779604819 @default.
- W2968439743 cites W2782865876 @default.
- W2968439743 cites W2801266108 @default.
- W2968439743 cites W2890286291 @default.
- W2968439743 cites W2918085071 @default.
- W2968439743 cites W2920207301 @default.