Matches in SemOpenAlex for { <https://semopenalex.org/work/W2968444800> ?p ?o ?g. }
- W2968444800 endingPage "79" @default.
- W2968444800 startingPage "64" @default.
- W2968444800 abstract "Cell surface molecules of retinal pigment epithelial (RPE) cells participate in the pathogenesis of retinal diseases. In an attempt to identify cell surface proteins that play a role in RPE cell-cell interactions, we have considered studying the expression, regulation, and signaling of ADGRE5/CD97, an adhesion G protein-coupled receptor family member, based on its known adhesive function in other cell types such as leukocytes. We showed that RPE cells express three isoforms of CD97 and identified inflammation-related cytokines as important mediators regulating CD97 expression. Whereas TNF-α and IFN-γ upregulated CD97, TGF-β decreased CD97 expression. Due to interaction with CD55, ARPE-19 cells firmly adhered to monocytes and T lymphocytes when overexpressing CD97, suggesting a role for CD97 in controlling leukocyte infiltration across the RPE-based blood-retinal barrier. CD97-mediated signaling acted synergistically with PDGF-BB and IFN-γ to regulate cell growth and survival, ensuring a cellular balance under inflammatory conditions. These findings suggest that CD97 on RPE cells serves to control leukocyte activation and trafficking in uveoretinal inflammation while at the same time regulating second messenger-mediated gene expression, cell growth, and survival." @default.
- W2968444800 created "2019-08-22" @default.
- W2968444800 creator A5007341947 @default.
- W2968444800 creator A5011319353 @default.
- W2968444800 creator A5045821020 @default.
- W2968444800 creator A5050036240 @default.
- W2968444800 creator A5062216432 @default.
- W2968444800 creator A5079205621 @default.
- W2968444800 creator A5088583341 @default.
- W2968444800 date "2019-08-09" @default.
- W2968444800 modified "2023-10-02" @default.
- W2968444800 title "The role of ADGRE5/CD97 in human retinal pigment epithelial cell growth and survival" @default.
- W2968444800 cites W1502724456 @default.
- W2968444800 cites W1504160775 @default.
- W2968444800 cites W1539394488 @default.
- W2968444800 cites W1562575950 @default.
- W2968444800 cites W1583577648 @default.
- W2968444800 cites W1724691932 @default.
- W2968444800 cites W1836215938 @default.
- W2968444800 cites W1918119607 @default.
- W2968444800 cites W1919230608 @default.
- W2968444800 cites W1966450087 @default.
- W2968444800 cites W1968577782 @default.
- W2968444800 cites W1970925422 @default.
- W2968444800 cites W1989268312 @default.
- W2968444800 cites W1990237608 @default.
- W2968444800 cites W1995016025 @default.
- W2968444800 cites W2000341893 @default.
- W2968444800 cites W2017974435 @default.
- W2968444800 cites W2018794902 @default.
- W2968444800 cites W2022799658 @default.
- W2968444800 cites W2028456697 @default.
- W2968444800 cites W2032084189 @default.
- W2968444800 cites W2041767939 @default.
- W2968444800 cites W2045268402 @default.
- W2968444800 cites W2049727981 @default.
- W2968444800 cites W2058173351 @default.
- W2968444800 cites W2059000778 @default.
- W2968444800 cites W2059820519 @default.
- W2968444800 cites W2061731519 @default.
- W2968444800 cites W2066273674 @default.
- W2968444800 cites W2070696872 @default.
- W2968444800 cites W2071290544 @default.
- W2968444800 cites W2071395712 @default.
- W2968444800 cites W2074232365 @default.
- W2968444800 cites W2077486579 @default.
- W2968444800 cites W2081236313 @default.
- W2968444800 cites W2099000660 @default.
- W2968444800 cites W2100126695 @default.
- W2968444800 cites W2111274886 @default.
- W2968444800 cites W2111689719 @default.
- W2968444800 cites W2140213726 @default.
- W2968444800 cites W2142886240 @default.
- W2968444800 cites W2145923454 @default.
- W2968444800 cites W2147204470 @default.
- W2968444800 cites W2159319913 @default.
- W2968444800 cites W2171524333 @default.
- W2968444800 cites W2330512231 @default.
- W2968444800 cites W2557016000 @default.
- W2968444800 cites W2888222431 @default.
- W2968444800 cites W4249883300 @default.
- W2968444800 cites W622192901 @default.
- W2968444800 doi "https://doi.org/10.1111/nyas.14210" @default.
- W2968444800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31397926" @default.
- W2968444800 hasPublicationYear "2019" @default.
- W2968444800 type Work @default.
- W2968444800 sameAs 2968444800 @default.
- W2968444800 citedByCount "4" @default.
- W2968444800 countsByYear W29684448002020 @default.
- W2968444800 countsByYear W29684448002021 @default.
- W2968444800 countsByYear W29684448002023 @default.
- W2968444800 crossrefType "journal-article" @default.
- W2968444800 hasAuthorship W2968444800A5007341947 @default.
- W2968444800 hasAuthorship W2968444800A5011319353 @default.
- W2968444800 hasAuthorship W2968444800A5045821020 @default.
- W2968444800 hasAuthorship W2968444800A5050036240 @default.
- W2968444800 hasAuthorship W2968444800A5062216432 @default.
- W2968444800 hasAuthorship W2968444800A5079205621 @default.
- W2968444800 hasAuthorship W2968444800A5088583341 @default.
- W2968444800 hasBestOaLocation W29684448001 @default.
- W2968444800 hasConcept C104317684 @default.
- W2968444800 hasConcept C127561419 @default.
- W2968444800 hasConcept C1491633281 @default.
- W2968444800 hasConcept C150555746 @default.
- W2968444800 hasConcept C16224149 @default.
- W2968444800 hasConcept C203014093 @default.
- W2968444800 hasConcept C2776914184 @default.
- W2968444800 hasConcept C2780827179 @default.
- W2968444800 hasConcept C55493867 @default.
- W2968444800 hasConcept C62112901 @default.
- W2968444800 hasConcept C62478195 @default.
- W2968444800 hasConcept C85789140 @default.
- W2968444800 hasConcept C86803240 @default.
- W2968444800 hasConcept C95444343 @default.
- W2968444800 hasConceptScore W2968444800C104317684 @default.
- W2968444800 hasConceptScore W2968444800C127561419 @default.
- W2968444800 hasConceptScore W2968444800C1491633281 @default.
- W2968444800 hasConceptScore W2968444800C150555746 @default.