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- W2968456211 abstract "Phenotype robustness to environmental fluctuations is a common biological phenomenon. Although most phenotypes involve multiple proteins that interact with each other, the basic principles of how such interactome networks respond to environmental unpredictability and change during evolution are largely unknown. Here we study interactomes of 1,840 species across the tree of life involving a total of 8,762,166 protein-protein interactions. Our study focuses on the resilience of interactomes to network failures and finds that interactomes become more resilient during evolution, meaning that interactomes become more robust to network failures over time. In bacteria, we find that a more resilient interactome is in turn associated with the greater ability of the organism to survive in a more complex, variable, and competitive environment. We find that at the protein family level proteins exhibit a coordinated rewiring of interactions over time and that a resilient interactome arises through gradual change of the network topology. Our findings have implications for understanding molecular network structure in the context of both evolution and environment." @default.
- W2968456211 created "2019-08-22" @default.
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- W2968456211 date "2019-07-30" @default.
- W2968456211 modified "2023-10-17" @default.
- W2968456211 title "Evolution of resilience in protein interactomes across the tree of life" @default.
- W2968456211 doi "https://doi.org/10.7490/f1000research.1117189.1" @default.
- W2968456211 hasPublicationYear "2019" @default.
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